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Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans

Published in Endocrinology. 2017, vol. 158, no. 5, p. 1074-1084
Abstract Most organisms, including humans, have developed an intrinsic system of circadian oscillators, allowing the anticipation of events related to the rotation of Earth around its own axis. The mammalian circadian timing system orchestrates nearly all aspects of physiology and behavior. Together with systemic signals, emanating from the central clock that resides in the hypothalamus, peripheral oscillators orchestrate tissue-specific fluctuations in gene expression, protein synthesis, and posttranslational modifications, driving overt rhythms in physiology and behavior. There is increasing evidence on the essential roles of the peripheral oscillators, operative in metabolically active organs in the regulation of body glucose homeostasis. Here, we review some recent findings on the molecular and cellular makeup of the circadian timing system and its implications in the temporal coordination of metabolism in health and disease.
Keywords AnimalsCircadian Clocks/genetics/physiologyCircadian Rhythm Signaling Peptides and Proteins/genetics/metabolismEnergy Metabolism/physiologyGlucose/metabolism/physiologyHomeostasis/physiologyHumansMammalsRodentia
PMID: 28324069
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Research group Endocrinologie et horloge circadienne (948)
FNS: 31003A-166700
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GACHON, Frédéric et al. Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans. In: Endocrinology, 2017, vol. 158, n° 5, p. 1074-1084. doi: 10.1210/en.2017-00218 https://archive-ouverte.unige.ch/unige:104592

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Deposited on : 2018-05-22

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