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Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model |
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Published in | Stroke. 2016, vol. 47, no. 12, p. 3048-3052 | |
Abstract | We previously showed that the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) increases cerebral microcirculation in a juvenile ischemic rat model. We address the roles of cyclooxygenase (COX)-elaborated prostaglandins in collateral recruitment and blood supply. | |
Keywords | 6-Ketoprostaglandin F1 alpha/metabolism — Animals — Cerebrovascular Circulation — Cyclooxygenase 2/metabolism — Cyclooxygenase 2 Inhibitors/pharmacology — Disease Models, Animal — Microcirculation — Prostaglandin-E Synthases/metabolism — Rats — Reperfusion Injury/metabolism | |
Identifiers | PMID: 27834752 | |
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Research group | Prévention des complications néonatales d'origine périnatale (990) | |
Citation (ISO format) | LEGER, Pierre-Louis et al. Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model. In: Stroke, 2016, vol. 47, n° 12, p. 3048-3052. doi: 10.1161/STROKEAHA.116.015095 https://archive-ouverte.unige.ch/unige:104564 |