Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model

Leger, Pierre-Louis; Pansiot, Julien; Besson, Valerie; Palmier, Bruno; Renolleau, Sylvain; Baud, Olivier; Cauli, Bruno; Charriaut-Marlangue, Christiane

doi:10.1161/STROKEAHA.116.015095

Scientific article

English

Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model

ContributorsLeger, Pierre-Louis; Pansiot, Julien; Besson, Valerie; Palmier, Bruno; Renolleau, Sylvain; Baud, Olivier; Cauli, Bruno; Charriaut-Marlangue, Christiane

Published inStroke, vol. 47, no. 12, p. 3048-3052

Publication date2016

Abstract

We previously showed that the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) increases cerebral microcirculation in a juvenile ischemic rat model. We address the roles of cyclooxygenase (COX)-elaborated prostaglandins in collateral recruitment and blood supply.

Keywords

6-Ketoprostaglandin F1 alpha/metabolism
Animals
Cerebrovascular Circulation
Cyclooxygenase 2/metabolism
Cyclooxygenase 2 Inhibitors/pharmacology
Disease Models, Animal
Microcirculation
Prostaglandin-E Synthases/metabolism
Rats
Reperfusion Injury/metabolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique

Research groups

Prévention des complications néonatales d'origine périnatale (990)

Citation (ISO format)

LEGER, Pierre-Louis et al. Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model. In: Stroke, 2016, vol. 47, n° 12, p. 3048–3052. doi: 10.1161/STROKEAHA.116.015095

Article (Published version)

Identifiers

PID : unige:104564
DOI : 10.1161/STROKEAHA.116.015095
PMID : 27834752

Journal ISSN0039-2499

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Cyclooxygenase-2-Derived Prostaglandins Mediate Cerebral Microcirculation in a Juvenile Ischemic Rat Model

We previously showed that the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole (7-NI) increases cerebral microcirculation in a juvenile ischemic rat model. We address the roles of cyclooxygenase (COX)-elaborated prostaglandins in collateral recruitment and blood supply.

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