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Quantitative Shear-Wave Elastography of the Liver in Preterm Neonates with Intra-Uterine Growth Restriction

Alison, Marianne
Biran, Valérie
Tanase, Anca
Bendavid, Matthieu
Blouet, Marie
Demené, Charlie
Sebag, Guy
Tanter, Mickael
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Published in PLOS ONE. 2015, vol. 10, no. 11, p. e0143220
Abstract The feasibility and reproducibility of liver stiffness measurements using Supersonic Shear-wave Imaging (SSI) in preterm neonate have not been reported. Our aim was to determine if liver stiffness differs between intra-uterine growth restriction (IUGR) and appropriate for gestational age (AGA) preterm infants with/without cholestasis. We measured liver stiffness (in kPa) in 45 AGA and 18 IUGR preterm infants, and assessed reproducibility in 26 preterms using Intraclass Correlation Coefficients (ICC) and Bland-Altman tests. Liver stiffness values were compared between AGA and IUGR with and without cholestasis and correlated with birth weight. Measurements showed high reproducibility (ICC = 0.94-0.98 for intra-operator, 0.86 for inter-operator) with good agreement (95% limits: -1.24 to 1.24 kPa). During the first postnatal week, liver stiffness was higher in IUGR (7.50 ±1.53 kPa) than in AGA infants (5.11 ±0.80 kPa, p<0.001). After day 8, liver stiffness remained unchanged in AGA but increased progressively in IUGR infants (15.57 ±6.49 kPa after day 21). Liver stiffness was higher in IUGR neonates with cholestasis (19.35 ± 9.80 kPa) than without cholestasis (7.72 ± 1.27 kPa, p<0.001). In conclusion, quantitative liver SSI in preterms is feasible and reproducible. IUGR preterms who will develop cholestasis present high liver stiffness even at birth, before biological cholestasis occurs.
Keywords Birth WeightCholestasis/diagnosis/diagnostic imaging/mortality/physiopathologyElasticity Imaging Techniques/instrumentation/methodsFemaleFetal Growth Retardation/diagnosis/diagnostic imaging/mortality/physiopathologyGestational AgeHumansInfantInfant, NewbornInfant, PrematureLiver/diagnostic imaging/physiopathologyMaleReproducibility of ResultsSurvival Analysis
PMID: 26580807
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Research group Prévention des complications néonatales d'origine périnatale (990)
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ALISON, Marianne et al. Quantitative Shear-Wave Elastography of the Liver in Preterm Neonates with Intra-Uterine Growth Restriction. In: PLOS ONE, 2015, vol. 10, n° 11, p. e0143220. doi: 10.1371/journal.pone.0143220 https://archive-ouverte.unige.ch/unige:104558

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Deposited on : 2018-05-18

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