Scientific Article
previous document  unige:103755  next document
add to browser collection

SPECT and PET analysis of subthalamic stimulation in Parkinson's disease: analysis using a manual segmentation

Haegelen, Claire
García-Lorenzo, Daniel
Jeune, Florence
Gibaud, Bernard
Riffaud, Laurent
Brassier, Gilles
Barillot, Christian
show hidden authors show all authors [1 - 10]
Published in Journal of neurology. 2009, vol. 257, no. 3, p. 375-382
Abstract The subthalamic nucleus (STN) has become an effective target of deep-brain stimulation (DBS) in severely disabled patients with advanced Parkinson's disease (PD). Clinical studies have reported DBS-induced adverse effects on cognitive functions, mood, emotion and behavior. STN DBS seems to interfere with the limbic functions of the basal ganglia, but the limbic effects of STN DBS are controversial. We measured prospectively resting regional cerebral metabolism (rCMb) with 18-fluorodeoxyglucose and PET, and resting regional cerebral blood flow (rCBF)with HMPAO and SPECT in six patients with Parkinson's disease. We compared PET and SPECT 1 month before and 3 months after STN DBS. On cerebral MRI, 13 regions of interest (ROI) were manually delineated slice by slice in frontal and limbic lobes. We obtained mean rCBF and rCMb values for each ROI and the whole brain. We normalized rCBF and rCMB values to ones for the whole brain volume, which we compared before and following STN DBS. No significant difference emerged in the SPECT analysis. PET analysis revealed a significant decrease in rCMb following STN DBS in the superior frontal gyri and left and right dorsolateral prefrontal cortex (p
Keywords Deep brain stimulationFunctional imagingLimbic systemParkinson's diseaseSubthalamic nucleus
Full text
Article (Published version) (292 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
HAEGELEN, Claire et al. SPECT and PET analysis of subthalamic stimulation in Parkinson's disease: analysis using a manual segmentation. In: Journal of Neurology, 2009, vol. 257, n° 3, p. 375-382. doi: 10.1007/s00415-009-5327-8

351 hits

0 download


Deposited on : 2018-04-23

Export document
Format :
Citation style :