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Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Hille, B.
Beech, D. J.
Mathie, A.
Shapiro, M. S.
Wollmuth, L. P.
Published in Life Sciences. 1995, vol. 56, no. 11-12, p. 989-992
Abstract Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.
Keywords Alkaloids/pharmacologyAnimalsCalcium Channels/ metabolismFuransGTP-Binding Proteins/ metabolismMuscarinic Agonists/pharmacologyMuscarinic Antagonists/pharmacologyNaphthalenesNeurons/drug effects/ metabolismOxotremorine/analogs & derivatives/pharmacologyPatch-Clamp TechniquesPertussis ToxinPiperidinesPirenzepine/pharmacologyRabbitsRatsReceptors, Muscarinic/drug effects/ metabolismSuperior Cervical Ganglion/drug effects/ metabolismVirulence Factors, Bordetella/pharmacology
PMID: 10188803
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HILLE, B. et al. Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. In: Life Sciences, 1995, vol. 56, n° 11-12, p. 989-992. doi: 10.1016/0024-3205(95)00038-8 https://archive-ouverte.unige.ch/unige:10298

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Deposited on : 2010-08-06

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