Scientific article

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Published inLife sciences, vol. 56, no. 11-12, p. 989-992
Publication date1995

Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

  • Alkaloids/pharmacology
  • Animals
  • Calcium Channels/ metabolism
  • Furans
  • GTP-Binding Proteins/ metabolism
  • Muscarinic Agonists/pharmacology
  • Muscarinic Antagonists/pharmacology
  • Naphthalenes
  • Neurons/drug effects/ metabolism
  • Oxotremorine/analogs & derivatives/pharmacology
  • Patch-Clamp Techniques
  • Pertussis Toxin
  • Piperidines
  • Pirenzepine/pharmacology
  • Rabbits
  • Rats
  • Receptors, Muscarinic/drug effects/ metabolism
  • Superior Cervical Ganglion/drug effects/ metabolism
  • Virulence Factors, Bordetella/pharmacology
Citation (ISO format)
HILLE, B. et al. Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. In: Life sciences, 1995, vol. 56, n° 11-12, p. 989–992. doi: 10.1016/0024-3205(95)00038-8
Main files (1)
ISSN of the journal0024-3205

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