en
Scientific article
English

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Published inLife sciences, vol. 56, no. 11-12, p. 989-992
Publication date1995
Abstract

Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

Keywords
  • Alkaloids/pharmacology
  • Animals
  • Calcium Channels/ metabolism
  • Furans
  • GTP-Binding Proteins/ metabolism
  • Muscarinic Agonists/pharmacology
  • Muscarinic Antagonists/pharmacology
  • Naphthalenes
  • Neurons/drug effects/ metabolism
  • Oxotremorine/analogs & derivatives/pharmacology
  • Patch-Clamp Techniques
  • Pertussis Toxin
  • Piperidines
  • Pirenzepine/pharmacology
  • Rabbits
  • Rats
  • Receptors, Muscarinic/drug effects/ metabolism
  • Superior Cervical Ganglion/drug effects/ metabolism
  • Virulence Factors, Bordetella/pharmacology
Citation (ISO format)
HILLE, B. et al. Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. In: Life sciences, 1995, vol. 56, n° 11-12, p. 989–992. doi: 10.1016/0024-3205(95)00038-8
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ISSN of the journal0024-3205
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