The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization

Eggermann, Emmanuel; Bayer, Laurence; Serafin, Mauro; Saint-Mleux, Benoit; Bernheim, Laurent; Machard, Daniele; Jones, B. E.; Muhlethaler, Michel

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Title		The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization
Authors		Eggermann, Emmanuel Bayer, Laurence Serafin, Mauro Saint-Mleux, Benoit Bernheim, Laurent Machard, Daniele Jones, B. E. Muhlethaler, Michel
Published in		Journal of Neuroscience. 2003, vol. 23, no. 5, p. 1557-1562
Abstract		Wakefulness depends on the activity of hypocretin-orexin neurons because their lesion results in narcolepsy. How these neurons maintain their activity to promote wakefulness is not known. Here, by recording for the first time from hypocretin-orexin neurons and comparing their properties with those of neurons expressing melanin-concentrating hormone, we show that hypocretin-orexin neurons are in an intrinsic state of membrane depolarization that promotes their spontaneous activity. We propose that wakefulness and associated energy expenditure thus depend on that property, which allows the hypocretin-orexin neurons to maintain a tonic excitatory influence on the central arousal and peripheral sympathetic systems.
Keywords		Action Potentials/drug effects/physiology — Animals — Arousal/physiology — Carrier Proteins/ metabolism — Cell Membrane/ physiology — Chelating Agents/pharmacology — Choline/pharmacology — Electric Stimulation — Excitatory Amino Acid Antagonists/pharmacology — Hypothalamic Hormones/metabolism — Hypothalamus/cytology — Intracellular Signaling Peptides and Proteins — Melanins/metabolism — Membrane Potentials/drug effects/physiology — Neurons/cytology/drug effects/ metabolism — Neuropeptides/ metabolism — Nickel/pharmacology — Patch-Clamp Techniques — Pituitary Hormones/metabolism — Rats — Sodium Channel Blockers/pharmacology — Synaptic Transmission/drug effects/physiology — Tetrodotoxin/pharmacology — Wakefulness/ physiology — Gamma-Aminobutyric Acid/pharmacology
Identifiers		PMID: 12629156
Full text		Article - Limited access to UNIGE Other version: http://www.jneurosci.org/cgi/reprint/23/5/1557.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation (ISO format)		EGGERMANN, Emmanuel et al. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. In: Journal of Neuroscience, 2003, vol. 23, n° 5, p. 1557-1562. https://archive-ouverte.unige.ch/unige:10241