en
Scientific article
English

The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization

Published inThe Journal of neuroscience, vol. 23, no. 5, p. 1557-1562
Publication date2003
Abstract

Wakefulness depends on the activity of hypocretin-orexin neurons because their lesion results in narcolepsy. How these neurons maintain their activity to promote wakefulness is not known. Here, by recording for the first time from hypocretin-orexin neurons and comparing their properties with those of neurons expressing melanin-concentrating hormone, we show that hypocretin-orexin neurons are in an intrinsic state of membrane depolarization that promotes their spontaneous activity. We propose that wakefulness and associated energy expenditure thus depend on that property, which allows the hypocretin-orexin neurons to maintain a tonic excitatory influence on the central arousal and peripheral sympathetic systems.

Keywords
  • Action Potentials/drug effects/physiology
  • Animals
  • Arousal/physiology
  • Carrier Proteins/ metabolism
  • Cell Membrane/ physiology
  • Chelating Agents/pharmacology
  • Choline/pharmacology
  • Electric Stimulation
  • Excitatory Amino Acid Antagonists/pharmacology
  • Hypothalamic Hormones/metabolism
  • Hypothalamus/cytology
  • Intracellular Signaling Peptides and Proteins
  • Melanins/metabolism
  • Membrane Potentials/drug effects/physiology
  • Neurons/cytology/drug effects/ metabolism
  • Neuropeptides/ metabolism
  • Nickel/pharmacology
  • Patch-Clamp Techniques
  • Pituitary Hormones/metabolism
  • Rats
  • Sodium Channel Blockers/pharmacology
  • Synaptic Transmission/drug effects/physiology
  • Tetrodotoxin/pharmacology
  • Wakefulness/ physiology
  • Gamma-Aminobutyric Acid/pharmacology
Citation (ISO format)
EGGERMANN, Emmanuel et al. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. In: The Journal of neuroscience, 2003, vol. 23, n° 5, p. 1557–1562.
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0270-6474
571views
0downloads

Technical informations

Creation08/06/2010 1:46:21 PM
First validation08/06/2010 1:46:21 PM
Update time03/14/2023 3:58:14 PM
Status update03/14/2023 3:58:14 PM
Last indexation02/12/2024 7:02:39 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack