UNIGE document Scientific Article
previous document  unige:10160  next document
add to browser collection

Vasopressin modulates lateral septal network activity via two distinct electrophysiological mechanisms

Allaman-Exertier, G.
Reymond-Marron, I.
Published in European journal of neuroscience. 2007, vol. 26, no. 9, p. 2633-2642
Abstract The lateral septal area is rich in vasopressin V(1A) receptors and is densely innervated by vasopressinergic axons, originating mainly from the bed nucleus of the stria terminalis and the amygdala. Genetic and behavioral studies provide evidence that activation of vasopressin receptors in this area plays a determinant role in promoting social recognition. What could be the neuronal mechanism underlying this effect? Using rat brain slices and whole-cell recordings, we found that lateral septal neurons are under the influence of a basal GABAergic inhibitory input. Vasopressin, acting via V(1A) but not V(1B) receptors, greatly enhanced this input in nearly all neurons. The peptide had no effect on miniature inhibitory postsynaptic currents, indicating that it acted on receptors located in the somatodendritic membrane, rather than on axon terminals, of GABAergic interneurons. Cell-attached recordings showed that vasopressin can cause a direct excitation of a subpopulation of lateral septal neurons by acting via V(1A) but not V(1B) receptors. The presence in the lateral septum of V(1A) but not of V(1B) receptors was confirmed by competition binding studies using light microscopic autoradiography. In conclusion, vasopressin appears to act in the lateral septum in a dual mode: (i) by causing a direct excitation of a subpopulation of neurons, and (ii) by causing an indirect inhibition of virtually all lateral septal neurons. This modulation by vasopressin of the lateral septal circuitry may be part of the neuronal mechanism by which the peptide, acting via V(1A) receptors, promotes social recognition.
Keywords AnimalsBinding, Competitive/drug effects/physiologyInhibitory Postsynaptic Potentials/drug effects/physiologyNerve Net/drug effects/*metabolismNeural Inhibition/drug effects/physiologyNeural Pathways/drug effects/*metabolismNeurons/drug effects/metabolismOrgan Culture TechniquesPatch-Clamp TechniquesRadioligand AssayRatsRats, Sprague-DawleyReceptors, Vasopressin/agonists/antagonists & inhibitors/drugEffects/*metabolismSeptal Nuclei/drug effects/*metabolismSocial BehaviorSynaptic Transmission/drug effects/physiologyVasopressins/pharmacology/*physiologyGamma-Aminobutyric Acid/metabolism
PMID: 17970727
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
ALLAMAN-EXERTIER, G. et al. Vasopressin modulates lateral septal network activity via two distinct electrophysiological mechanisms. In: European journal of neuroscience, 2007, vol. 26, n° 9, p. 2633-2642. doi: 10.1111/j.1460-9568.2007.05866.x https://archive-ouverte.unige.ch/unige:10160

486 hits

0 download


Deposited on : 2010-08-06

Export document
Format :
Citation style :