Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine

Muller, Dominique; Bittar, P.; Boddeke, H.

doi:10.1016/0304-3940(92)90126-r

Scientific article

English

Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine

Contributors

Muller, Dominique; Bittar, P.; Boddeke, H.

Published in

Neuroscience letters, vol. 135, no. 1, p. 18-22

Publication date

1992

Abstract

We have studied the effects of staurosporine, an antagonist of the catalytic subunit of protein kinase C, on the mechanisms of long-term potentiation (LTP) in rat hippocampal slices maintained in vitro. Application of staurosporine did not affect pre-established LTP, but resulted in a decaying potentiation when high frequency stimulation was delivered in its presence. However, coactivation of two inputs to the same group of CA1 neurons during high frequency stimulation transformed the decaying potentiation into stable LTP. Staurosporine also reduced the NMDA receptor-mediated component of synaptic responses to burst stimulation. It is concluded that the PKC antagonist interferes with LTP induction, but not expression mechanisms.

Keywords

Alkaloids/ pharmacology
Animals
Electric Stimulation
Evoked Potentials/drug effects
Hippocampus/ physiology
Kinetics
Neurons/drug effects/ physiology
Protein Kinase C/ antagonists & inhibitors
Pyramidal Tracts/drug effects/ physiology
Rats
Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
Staurosporine

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

Citation (ISO format)

MULLER, Dominique, BITTAR, P., BODDEKE, H. Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine. In: Neuroscience letters, 1992, vol. 135, n° 1, p. 18–22. doi: 10.1016/0304-3940(92)90126-r

Identifiers

PID : unige:10106
DOI : 10.1016/0304-3940(92)90126-r
PMID : 1347415

Journal ISSN

0304-3940

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Induction of stable long-term potentiation in the presence of the protein kinase C antagonist staurosporine

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation