CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
ContributorsCantley, Jennifer L; Yoshimura, Toru; Camporez, Joao Paulo G; Zhang, Dongyan; Jornayvaz, François; Kumashiro, Naoki; Guebre-Egziabher, Fitsum; Jurczak, Michael J; Kahn, Mario; Guigni, Blas A; Serr, Julie; Hankin, Joseph; Murphy, Robert C; Cline, Gary W; Bhanot, Sanjay; Manchem, Vara Prasad; Brown, J Mark; Samuel, Varman T; Shulman, Gerald I
Published inProceedings of the National Academy of Sciences, vol. 110, no. 5, p. 1869-1874
Publication date2013
Abstract
Keywords
- 1-Acylglycerol-3-Phosphate O-Acyltransferase/genetics/metabolism
- Adipose Tissue
- White/drug effects/metabolism
- Animals
- Cell Membrane/drug effects/metabolism
- Diet
- High-Fat
- Diglycerides/metabolism
- Endoplasmic Reticulum/drug effects/metabolism
- Gene Expression/drug effects
- Gene Knockdown Techniques
- Humans
- Immunoblotting
- Injections
- Intraperitoneal
- Insulin Resistance
- Lipids/chemistry
- Liver/drug effects/metabolism/pathology
- Male
- Mice
- Mice
- Inbred C57BL
- Oligonucleotides
- Antisense/administration & dosage/genetics
- Protein Kinase C-epsilon/metabolism
- Protein Transport/drug effects
- Reverse Transcriptase Polymerase Chain Reaction
Affiliation
Citation (ISO format)
CANTLEY, Jennifer L et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance. In: Proceedings of the National Academy of Sciences, 2013, vol. 110, n° 5, p. 1869–1874. doi: 10.1073/pnas.1219456110
Main files (1)
Article (Published version)
Identifiers
- PID : unige:100701
- DOI : 10.1073/pnas.1219456110
- PMID : 23302688
ISSN of the journal0027-8424