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Scientific article
French

Les "synapses neurosécrétoires", hier et aujourd'hui

Contributors

Dreifuss, Jean-Jacques; Raggenbass, Mario

Published in

Annales d'endocrinologie, vol. 46, no. 1, p. 47-53

Publication date

1985

Abstract

The concept of peptidergic neurotransmission in the central nervous system ranks high in contemporary neurobiology. It was first formulated by J. Barry when reporting, in 1954-55, his observation with light microscopy of the existence of "Gomori-positive" synapses in sections of the mammalian brain. However, this important discovery had virtually no impact on the scientific community for about twenty years because of an extremely restrictive definition of "neurosecretion" during this period by the practitioners of the new field known as neuroendocrinology. The rejection of Barry's finding raises numerous epistemological questions; it provides another example of a "premature discovery", such as those of A.A. Berthold (testicular transplant studies) and of J.G. Mendel (artificial plant hybridization) during the last century.

Keywords

  • Animals
  • Calcium/metabolism
  • Hippocampus/physiology
  • Hypothalamus/physiology
  • Microscopy, Electron
  • Models, Biological
  • Neurosecretion
  • Neurosecretory Systems/ cytology
  • Oxytocin/pharmacology
  • Potassium/pharmacology
  • Rats
  • Receptors, Angiotensin/metabolism
  • Receptors, Oxytocin
  • Snakes
  • Synapses/ physiology
  • Vasopressins/metabolism
  • Veratridine/pharmacology

UNIGE affiliation entities

Citation (ISO format)

DREIFUSS, Jean-Jacques, RAGGENBASS, Mario. Les ‘synapses neurosécrétoires’, hier et aujourd’hui. In: Annales d’endocrinologie, 1985, vol. 46, n° 1, p. 47–53.

Identifiers

Journal ISSN

0003-4266
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Technical informations

Creation

06/08/2010 10:47:05

First validation

06/08/2010 10:47:05

Update

14/03/2023 15:57:18

Status update

14/03/2023 15:57:18

Last indexation

29/10/2024 16:23:30
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