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Title

Modulation by divalent cations of the current generated by vasopressin in facial motoneurons
Authors
Alberi, Stefano
Dubois-Dauphin, Michel
Dreifuss, Jean-Jacques
Raggenbass, Mario
Published in Brain Research. 1993, vol. 624, no. 1-2, p. 326-330
Abstract Vasopressin generates a voltage-gated, sodium-dependent current in facial motoneurons in brainstem slices. Reducing the extracellular calcium concentration from 2 to 0.01 mM caused a 30 to 120% increase in the amplitude of this current. Lowering extracellular magnesium also enhanced it, but less efficiently. In the physiological solution, the response of facial neurons to vasopressin is thus partially blocked. Increasing extracellular calcium was without effect. Current-voltage curves indicate that the vasopressin current reversed at around 0 mV and suggest that the low-calcium-induced potentiation was due to an attenuation of the region of negative slope conductance.
Keywords Animals — Brain Stem/ physiology — Calcium/metabolism — Cations, Divalent/ metabolism — Electric Conductivity — Extracellular Space/metabolism — Facial Nerve/ physiology — Magnesium/metabolism — Male — Motor Neurons/ drug effects/ physiology — Osmolar Concentration — Rats — Rats, Sprague-Dawley — Vasopressins/ physiology
Identifiers
PMID: 8252410
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Structures
Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales
Citation
(ISO format) 		ALBERI, Stefano et al. Modulation by divalent cations of the current generated by vasopressin in facial motoneurons. In: Brain Research, 1993, vol. 624, n° 1-2, p. 326-330. https://archive-ouverte.unige.ch/unige:10017

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Deposited on : 2010-08-06

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