Section des sciences pharmaceutiques

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2021

Scientific Articles

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A cytotoxic porphyrin from North Pacific brittle star Ophiura sarsiiKlimenko, Antonina; Huber, Robin; Marcourt, Laurence; Chardonnens, Estelle; ... Katanaev, Vladimir
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Algorithms to optimize multi-column chromatographic separations of proteinsCodesido Sanchez, Santiago; Guillarme, Davy; Fekete, Szabolcs;
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Alternative mobile phase additives for the characterization of protein biopharmaceuticals in liquid chromatography – Mass spectrometryLardeux, Honorine; Duivelshof, Bastiaan L.; Colas, Olivier; Beck, Alain; ... D’Atri, Valentina
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Analytical challenges encountered and the potential of supercritical fluid chromatography: A perspective of five expertsOlesik, Susan; West, Caroline; Guillarme, Davy; Mangelings, Debby; Novakova, Lucie
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Angiogenesis Is Differentially Modulated by Platelet-Derived ProductsBerndt, Sarah; Carpentier, Gilles; Turzi, Antoine; Borlat, Frédéric; ... Modarressi Ghavami, Seyed Ali
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Anti-angiogenic agents - overcoming tumour endothelial cell anergy and improving immunotherapy outcomesHuinen, Zowi R; Huijbers, Elisabeth J M; van Beijnum, Judy R; Nowak-Sliwinska, Patrycja; Griffioen, Arjan W
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Antitumor Effect of 5-Fluorouracil-Loaded Liposomes Containing n-3 Polyunsaturated Fatty Acids in Two Different Colorectal Cancer Cell LinesDupertuis, Yves Marc; Boulens, Nathalie; Angibaud, Emmanuelle; Briod, Anna-Sophia; ... Pichard, Claude
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Approaches in metabolomics for regulatory toxicology applicationsOlesti, Eulalia; Gonzalez Ruiz, Victor; Wilks, Martin F; Boccard, Julien; Rudaz, Serge
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Association of Incomplete Adherence to Antiretroviral Therapy With Cardiovascular Events and Mortality in Virologically Suppressed Persons With HIV: The Swiss HIV Cohort StudyCastillo-Mancilla, Jose R; Cavassini, Matthias; Schneider Voirol, Marie Paule; Furrer, Hansjakob; ... Yerly, S
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Bioguided identification of pentacyclic triterpenoids as anti-inflammatory bioactive constituents of Ocimum gratissimum extractDzoyem, Jean Paul; Nganteng, Dieu Ne Dort; Melong, Raduis; Wafo, Pascal; ... Delie Salmon, Florence
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Bispecific antibody characterization by a combination of intact and site-specific/chain-specific LC/MS techniquesDuivelshof, Bastiaan; Debecker, Alain; Guillarme, Davy; D'Atri, Valentina;
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Capillary Electrophoresis Instruments for Medical Applications and Falsified Drug Analysis/Quality Control in Developing CountriesTobolkina, Elena; Rudaz, Serge;
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Considerations for the delivery of STING ligands in cancer immunotherapyPetrovic, Marija; Borchard, Gerrit; Jordan, Olivier;
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Digital Medication Adherence Support: Could Healthcare Providers Recommend Mobile Health Apps?Backes, Claudine; Moyano, Carla; Rimaud, Camille; Bienvenu, Christine; Schneider Voirol, Marie Paule
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DNA Vaccine Administered by Cationic Lipoplexes or by In Vivo Electroporation Induces Comparable Antibody Responses against SARS-CoV-2 in MicePeletta, Allegra; Prompetchara, Eakachai; Tharakhet, Kittipan; Kaewpang, Papatsara; ... Borchard, Gerrit
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Emergency and disaster preparedness of european hospital pharmacists: A surveySchumacher, Laurence; Bonnabry, Pascal; Widmer, Nicolas;
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Empirical correction of non-linear pH gradients and a tool for application to protein ion exchange chromatographyFekete, Szabolcs; Murisier, Amarande; Lauber, Matthew; Guillarme, Davy;
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Enantiomeric methadone quantitation on real post-mortem dried matrix spots samples: Comparison of liquid chromatography and supercritical fluid chromatography coupled to mass spectrometryMueller, Françoise; Losacco, Gioacchino Luca; Nicoli, Raul; Guillarme, Davy; ... Grata, E
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Evaluation of a nanoflow interface based on the triple-tube coaxial sheath-flow sprayer for capillary electrophoresis-mass spectrometry coupling in metabolomicsFerre, Sabrina; Drouin, Nicolas; Gonzalez Ruiz, Victor; Rudaz, Serge;
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Expanding the range of sub/supercritical fluid chromatography: Advantageous use of methanesulfonic acid in water-rich modifiers for peptide analysisLosacco, Gioacchino Luca; Da Silva, Jimmy Oliviera; Liu, Jinchu; Regalado, Erik L; ... Guillarme, Davy
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Forcing dividing cancer cells to die; low-dose drug combinations to prevent spindle pole clusteringDucrey, Eloise; Castrogiovanni, Cédric; Meraldi, Patrick; Nowak-Sliwinska, Patrycja;
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Free Excel Software for Performing Virtual Liquid ChromatographyGuillarme, Davy; Balazs, Bobably; Veuthey, Jean-Luc;
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From a single steroid to the steroidome: Trends and analytical challengesOlesti, Eulalia; Boccard, Julien; Visconti, Gioele; Gonzalez Ruiz, Victor; Rudaz, Serge
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From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein DegradationCecchini, Carlotta; Pannilunghi, Sara; Tardy, Sébastien; Scapozza, Leonardo;
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Functional and anatomical characterization of atrophic age-related macular degeneration in an aged mouse modelTobalem, Stéphan Jonathan; Kecik, Mateusz Mariusz; Midroit, Maëllie; Scaldino, Djehna; ... Kropp, Martina
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Gaining Insights Into Metabolic Networks Using Chemometrics and Bioinformatics: Chronic Kidney Disease as a Clinical ModelBoccard, Julien; Schvartz, Domitille; Codesido Sanchez, Santiago; Hanafi, Mohamed; ... Rudaz, Serge
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Glomerular macrophages in human auto- and allo-immune nephritisMoll, Solange; Angeletti, Andrea; Scapozza, Leonardo; Cavalli, Andrea; ... Prunotto, Marco
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Heat-stability study of various insulin types in tropical temperature conditions: new insights towards improving diabetes careKaufmann, Béatrice; Boulle, Philippa; Berthou, Flavien; Fournier, Margot; ... Scapozza, Leonardo
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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MSCamperi, Julien; Grunert, Ingrid; Heinrich, Katrin; Winter, Martin; ... Stella, Cinzia
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Interlaboratory study of a supercritical fluid chromatography method for the determination of pharmaceutical impurities: Evaluation of multi-systems reproducibilityDispas, Amandine; Clarke, Adrian; Grand-Guillaume Perrenoud, Alexandre; Losacco, Gioacchino Luca; ... Hubert, Philippe
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Interprofessional Medication Adherence Program for Patients With Diabetic Kidney Disease: Protocol for a Randomized Controlled and Qualitative Study (PANDIA-IRIS)Bandiera, Carole; Dotta-Celio, Jennifer; Locatelli, Isabella; Nobre, Dina; ... Schneider Voirol, Marie Paule
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Ion mobility-high resolution mass spectrometry in anti-doping analysis. Part I: Implementation of a screening method with the assessment of a library of substances prohibited in sportsPlachká, Kateřina; Pezzatti, Julian; Musenga, Alessandro; Nicoli, Raul; ... Guillarme, Davy
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Ion mobility-high resolution mass spectrometry in doping control analysis. Part II: Comparison of acquisition modes with and without ion mobilityPlachká, Kateřina; Pezzatti, Julian; Musenga, Alessandro; Nicoli, Raul; ... Guillarme, Davy
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Isolation and identification of isocoumarin derivatives with specific inhibitory activity against wnt pathway and metabolome characterization of lasiodiplodia venezuelensisPellissier, Léonie; Koval, Alexey; Marcourt, Laurence; Ferreira Queiroz, Emerson; ... Wolfender, Jean-Luc
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Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in MiceWagner, Julia; Gößl, Dorothée; Ustyanovska, Natasha; Xiong, Mengyao; ... Bourquin, Carole
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Metabotypes of Pseudomonas aeruginosa Correlate with Antibiotic Resistance, Virulence and Clinical Outcome in Cystic Fibrosis Chronic InfectionsMoyne, Oriane; Castelli, Florence; Bicout, Dominique J; Boccard, Julien; ... Le Gouëllec, Audrey
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Metamorphosis of supercritical fluid chromatography: A viable tool for the analysis of polar compounds?Losacco, Gioacchino Luca; Veuthey, Jean-Luc; Guillarme, Davy;
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Microwave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymersThauvin, Cédric; Maudens, Pierre Marc Xavier; Allémann, Eric;
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Multi-dimensional LC-MS: the next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approachesCamperi, Julien; Goyon, Alexandre; Guillarme, Davy; Zhang, Kelly; Stella, Cinzia
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Negative gradient slope methods to improve the separation of closely eluting proteinsFekete, Szabolcs; Murisier, Amarande; Nguyen, Jennifer M.; Lauber, Matthew A.; Guillarme, Davy
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New perspective for the in-field analysis of cannabis samples using handheld near-infrared spectroscopy: A case study focusing on the determination of Δ9-tetrahydrocannabinolDeidda, Riccardo; Coppey, Florentin; Damergi, Dhouha; Schelling, Cédric; ... Ziemons, Éric
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New wide-pore superficially porous stationary phases with low hydrophobicity applied for the analysis of monoclonal antibodiesFekete, Szabolcs; Murisier, Amarande; Beck, Alain; Lawhorn, Jason; ... Guillarme, Davy
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Osteoarthritis In Vitro Models: Applications and Implications in Development of Intra-Articular Drug Delivery SystemsDe Lacerda Salgado, Carlota; Jordan, Olivier; Allémann, Eric;
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Pregnancy outcome following first-trimester exposure to fingolimod: A collaborative ENTIS studyPauliat, Emmanuelle; Onken, Marlies; Weber-Schoendorfer, Corinna; Rousson, Valentin; ... Winterfeld, Ursula
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Prevalence of Polypharmacy and Inappropriate Medication in Adults With Intellectual Disabilities in a Hospital Setting in SwitzerlandLonchampt, Sophie; Gerber, Fabienne; Aubry, Jean-Michel; Desmeules, Jules Alexandre; ... Besson, Marie
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Primary cilia control endothelial permeability by regulating expression and location of junction proteinsDiagbouga, Mannekomba Roxane; Morel, Sandrine; Cayron, Anne France Judith; Haemmerli, Julien; ... Kwak, Brenda
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Psychological distress and well-being among students of health disciplines: the importance of academic satisfactionFranzen, Jessica; Jermann, Françoise; Ghisletta, Paolo; Rudaz, Serge; ... Tran, Nguyen Toan
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RB217, RB218 and RB219 antibodies recognize 
Protoporphyrin IX by ELISAHammel, Philippe; Lange, Norbert;
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Rivaroxaban and medication adherence – A cohort study (RIVA): Qualitative resultsDotta-Celio, Jennifer; Alatri, Adriano; Salvi, Monique; Mazzolai, Lucia; Schneider Voirol, Marie Paule
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Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on testing and interpretation of comparative in vitro metabolism studiesHernandez‐Jerez, Antonio F; Adriaanse, Paulien; Aldrich, Annette; Berny, Philippe; ... Parra Morte, Juan Manuel
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State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates SynthesisDeslignière, Evolène; Ehkirch, Anthony; Duivelshof, Bastiaan; Toftevall, Hanna; ... Cianférani, Sarah
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Steroid profiling by UHPLC-MS/MS in dried blood spots collected from healthy women with and without testosterone gel administrationSalamin, Olivier; Nicoli, Raul; Xu, Cheng; Boccard, Julien; ... Kuuranne, Tiia
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Swiss Armed Forces deployment during the COVID-19 pandemic: militia pharmacy officers' roles and dutiesWidmer, Nicolas; Abbet, Christian; Brunner, Joël; Faro Barros, Jonathan; ... Herklotz, Roberto
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The importance of being metal-free: The critical choice of column hardware for size exclusion chromatography coupled to high resolution mass spectrometryMurisier, Amarande; Fekete, Szabolcs; Guillarme, Davy; D'Atri, Valentina;
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The tyrosine kinase inhibitor nilotinib inhibits SARS‐CoV‐2 in vitroCagno, Valeria; Magliocco, Gaëlle; Tapparel, Caroline; Daali, Youssef;
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Therapeutic Fc‐fusion proteins: Current analytical strategiesDuivelshof, Bastiaan; Murisier, Amarande; Camperi, Julien; Fekete, Szabolcs; ... D'Atri, Valentina
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Thymol and Piperine-Loaded Poly(D,L-lactic-co-glycolic acid) Nanoparticles Modulate Inflammatory Mediators and Apoptosis in Murine MacrophagesDzoyem, Jean Paul; Boulens, Nathalie; Allémann, Eric; Delie Salmon, Florence;
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Towards a simple on-line coupling of ion exchange chromatography and native mass spectrometry for the detailed characterization of monoclonal antibodiesMurisier, Amarande; Duivelshof, Bastiaan; Fekete, Szabolcs; Bourquin, Julien; ... D'Atri, Valentina
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Ultra-short ion-exchange columns for fast charge variants analysis of therapeutic proteinsNavarro-Huerta, Jose Antonio; Murisier, Amarande; Nguyen, Jennifer M.; Lauber, Matthew A.; ... Fekete, Szabolcs
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Untargeted metabolomics uncovers the essential lysine transporter in toxoplasma gondiiKloehn, Joachim; Lunghi, Matteo; Varesio, Emmanuel; Dubois, David; Soldati-Favre, Dominique
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Use of Ultra-short Columns for Therapeutic Protein Separations, Part 2: Designing the Optimal Column Dimension for Reversed-Phase Liquid ChromatographyFekete, Szabolcs; Murisier, Amarande; Nguyen, Jennifer M; Bolton, Michael J.; ... Guillarme, Davy
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Use of Ultrashort Columns for Therapeutic Protein Separations. Part 1: Theoretical Considerations and Proof of ConceptFekete, Szabolcs; Bobaly, Balazs; Nguyen, Jennifer M; Beck, Alain; ... Guillarme, Davy
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Using 1.5 mm internal diameter columns for optimal compatibility with current liquid chromatographic systemsFekete, Szabolcs; Murisier, Amarande; Losacco, Gioacchino Luca; Lawhorn, Jason; ... Guillarme, Davy
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Vascular-targeted micelles as a specific MRI contrast agent for molecular imaging of fibrin clots and cancer cellsVorobiev, Vassily; Adriouach, Souad; Crowe, Lindsey; Lenglet, Sébastien; ... Allémann, Eric
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Wound Healing Promotion by Hyaluronic Acid: Effect of Molecular Weight on Gene Expression and In Vivo Wound ClosureKawano, Yayoi; Patrulea, Viorica; Sublet, Emmanuelle; Borchard, Gerrit; ... Hanawa, Takehisa

Professional Articles

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Biologics Explorer - Sitting Down With… Davy Guillarme, Senior Lecturer and Research Associate, School of Pharmaceutical Sciences, University of Geneva, SwitzerlandGuillarme, Davy;

Book Chapters

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Characterization of Glycosylated Proteins at Subunit Level by HILIC/MSD'Atri, Valentina; Guillarme, Davy;
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Fast Afucosylation Profiling of Glycoengineered Antibody Subunits by Middle-Up Mass SpectrometryWagner-Rousset, Elsa; Colas, Olivier; Chenu, Stéphane; François, Yannis-Nicolas; ... Beck, Alain

Doctoral Thesis

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A novel dual-imaging probe for the detection of progressive ovarian cancerLitvinenko, Alexandra;
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Adapting a naturally occuring protein cage to modulate an array of therapeutic delivery properties in various disease settingsShatz, Whitney Lauren;
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Evaluation et systématisation des pratiques de prescription médicamenteuse chez les adultes avec déficience intellectuelleLonchampt, Sophie;
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Evolution of sub/supercritical fluid chromatography – mass spectrometry for the analysis of highly polar compounds and biological matricesLosacco, Gioacchino Luca;
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Intra-articular sustained release carriers for osteoarthritis management: formulation and bioactivity evaluation studiesDe Lacerda Salgado, Carlota;
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Investigating the cutaneous spatial biodistribution of pharmaceutical molecules after topical application: From the design of polymeric micelle formulations to the development of quantitative and qualitative techniquesQuartier, Julie;
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New multidrug cocktails for treatment-naive and -resistant clear cell renal cell carcinomaRausch, Magdalena;
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Potential and Challenges in Improving Cancer Immunotherapy with Agonists for Nucleic Acid SensorsWagner, Julia;

2020

Scientific Articles

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A combined activation mechanism for the glucagon receptorMattedi, Giulio; Acosta-Gutiérrez, Silvia; Clark, Timothy; Gervasio, Francesco Luigi;
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A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milkWeisskopf, Etienne; Guidi, Monia; Fischer, Céline J; Bickle Graz, Myriam; ... Csajka, Chantal
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AI334, AQ806, AR222, AR249, AS274, AS708, RB572, RB574 and RB596 antibodies recognize SARS-CoV-2 viral particles by dot blotLacombe, Jérome; Zenhausern, Frédéric; Cosson, Pierre;
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An Adherence-Enhancing Program Increases Retention in Care in the Swiss HIV CohortKamal, Susan; Glass, Tracy R; Doco-Lecompte, Thanh; Locher, Sophie; ... Schneider Voirol, Marie Paule
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An Update on Antimicrobial Peptides (AMPs) and Their Delivery Strategies for Wound InfectionsPatrulea, Viorica; Borchard, Gerrit; Jordan, Olivier;
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Antiproliferative activity of a new xanthone derivative from leaves of Garcinia nobilis EnglFouotsa, Hugues; Dzoyem, Jean Paul; Lannang, Alain Meli; Stammler, Hans-Georg; ... Sewald, Norbert
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Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principlesBrillatz, Théo; Jacmin, Maxime; Vougogiannopoulou, Konstantina; Petrakis, Eleftherios A.; ... Wolfender, Jean-Luc
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Applicability of Supercritical fluid chromatography–Mass spectrometry to metabolomics. II–Assessment of a comprehensive library of metabolites and evaluation of biological matricesLosacco, Gioacchino Luca; Ismail, Omar; Pezzatti, Julian; Gonzalez Ruiz, Victor; ... Guillarme, Davy
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AR222, AR249, AS274, AS702 and AS708 antibodies recognize the spike S protein from SARS-CoV-2 by immunofluorescenceMarchetti, Anna; Zenhausern, Frédéric;
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Are Antimicrobial Peptide Dendrimers an Escape from ESKAPE?Kawano, Yayoi; Jordan, Olivier; Hanawa, Takehisa; Borchard, Gerrit; Patrulea, Viorica
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AU304 and RB576 antibodies recognize the membrane M protein from SARS-CoV-1 and -2 by immunofluorescenceMarchetti, Anna; Zenhausern, Frédéric;
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Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysisCamperi, Julien; Guillarme, Davy; Lei, Ming; Stella, Cinzia;
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Bacterial cell cycle control by citrate synthase independent of enzymatic activityBerge, Matthieu; Pezzatti, Julian; Gonzalez Ruiz, Victor; Degeorges, Laurence; ... Viollier, Patrick
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Bioavailability of Vortioxetine After a Roux-en-Y Gastric BypassVandenberghe, Frederik; Gilet, Patricia; Daali, Youssef; Favre, Lucien Ody; Eap, Chin Bin
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Buyers’ club : une alternative pour l’accès au traitement ?Borcic, Valentine; Calmy, Alexandra; Hurst, Samia; Jackson, Yves-Laurent Julien; ... Vernaz-Hegi, Nathalie
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Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound AnnotationDrouin, Nicolas; van Mever, Marlien; Zhang, Wei; Tobolkina, Elena; ... Ramautar, Rawi
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Combining Machine Learning and Enhanced Sampling Techniques for Efficient and Accurate Calculation of Absolute Binding Free EnergiesEvans, Rhys; Hovan, Ladislav; Tribello, Gareth A; Cossins, Benjamin P; ... Gervasio, Francesco Luigi
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Combining the advantages of multilevel and orthogonal partial least squares data analysis for longitudinal metabolomics: Application to kidney transplantationGagnebin, Yoric; Pezzatti, Julian; Lescuyer, Pierre; Boccard, Julien; ... Rudaz, Serge
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Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)de Boer, Rudolf A; Hulot, Jean-Sébastien; Tocchetti, Carlo Gabriele; Aboumsallem, Joseph Pierre; ... Backs, Johannes
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Comparison of Bioinformatics Pipelines and Operating Systems for the Analyses of 16S rRNA Gene Amplicon Sequences in Human Fecal SamplesMarizzoni, Moira; Gurry, Thomas; Provasi, Stefania; Greub, Gilbert; ... Cattaneo, Annamaria
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Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry ApproachFernández-García, Miguel; Rey-Stolle, Fernanda; Boccard, Julien; Reddy, Vineel P.; ... Barbas, Coral
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