Section des sciences pharmaceutiques

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2017

Scientific Articles

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Achievable separation performance and analysis time in current liquid chromatographic practice for monoclonal antibody separationsFekete, Szabolcs; Veuthey, Jean-Luc; Guillarme, Davy;
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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical CompoundsGuillarme, Davy; Veuthey, Jean-Luc;
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Development of a fast workflow to screen the charge variants of therapeutic antibodiesWagner-Rousset, Elsa; Fekete, Szabolcs; Morel-Chevillet, Laura; Colas, Olivier; ... Beck, Alain
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HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurementsBujard, Alban; Petit, Charlotte; Carrupt, Pierre-Alain; Rudaz, Serge; Schappler, Julie
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersCusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part 1Guillarme, Davy; Veuthey, Jean-Luc;
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Indirect quantitative structure-retention relationship for steroid identification: A chemometric challenge at "Chimiométrie 2016"Randazzo, Giuseppe Marco; Vigneau, Evelyne; Courcoux, Philippe; Harrouet, Corentin; ... Rudaz, Serge
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Optimization of non-linear gradient in hydrophobic interaction chromatography for the analytical characterization of antibody-drug conjugatesBobaly, Balazs; Randazzo, Giuseppe Marco; Rudaz, Serge; Guillarme, Davy; Fekete, Szabolcs
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Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical StudyPetit, Charlotte; Ceccarelli, Martina; Cretton, Sylvian; Houriet, Joëlle; ... Wolfender, Jean-Luc
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Perivascular medical devices and drug delivery systems: Making the right choicesMylonaki, Ioanna; Allémann, Eric; Saucy, François; Haefliger, Jacques-Antoine; ... Jordan, Olivier
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Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatographyDispas, Amandine; Desfontaine, Vincent; Andri, Bertyl; Lebrun, Pierre; ... Hubert, Philippe
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Separation of antibody drug conjugate species by RPLC: A genericmethod development approachFekete, Szabolcs; Molnar, Imre; Guillarme, Davy;
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The importance of system band broadening in modern size exclusion chromatographyGoyon, Alexandre; Guillarme, Davy; Fekete, Szabolcs;

Professional Articles

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Diagnostic des hémoglobinopathies par spectrométrie de masseCoelho Graca, Didia; Scherl, Alexander; Samii, Kaveh; Hochstrasser, Denis; Lescuyer, Pierre

Book Chapters

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Hyphenated Detectors: Mass SpectrometryDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;

Doctoral Thesis

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Sustained release systems for the perivascular administration of atorvastatin to prevent vein graft failureMylonaki, Ioanna;

2016

Scientific Articles

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An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposureSpaggiari, Dany; Daali, Youssef; Rudaz, Serge;
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Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I − Optimization of separation conditionsSarrut, Morgane; Corgier, Amélie; Fekete, Szabolcs; Guillarme, Davy; ... Heinisch, Sabine
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Analysis of Riboflavin Compounds in the Rabbit Cornea In VivoHammer, Arthur; Rudaz, Serge; Guinchard, Sylvie; Kling, Sabine; ... Hafezi, Farhad
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Analytical Strategies for Doping Control Purposes: Needs, Challenges, and PerspectivesNicoli, Raul; Guillarme, Davy; Leuenberger, Nicolas; Baume, Norbert; ... Veuthey, Jean-Luc
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Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound BandagesAbdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; ... Applegate, Lee Ann
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Aspirin response: Differences in serum thromboxane B2 levels between clinical studiesBrun, Charlotte; Daali, Youssef; Combescure, Christophe; Zufferey Bakos, Anne; ... Frelinger, Andrew L (3rd)
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Best practice strategies to safeguard drug prescribing and drug administration: an anthology of expert views and opinionsSeidling, Hanna M; Stützle, Marion; Hoppe-Tichy, Torsten; Allenet, Benoît; ... Haefeli, Walter E
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Characterization of pDNA-TMC Nanoparticle Interaction and StabilityPoecheim, Johanna; Patrulea, Viorica; Reichert, Christian; Borchard, Gerrit;
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Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein BiopharmaceuticalsFekete, Szabolcs; Guillarme, Davy; Pat, Sandra; Koen, Sandra;
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approachMarsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
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Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometrySorensen, Matthew; Harmes, David C.; Stoll, Dwight R.; Staples, Gergory O.; ... Beck, Alain
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Computer assisted liquid chromatographic method development for the separation of therapeutic proteinsTyteca, Eva; Veuthey, Jean-Luc; Desmet, Gert; Guillarme, Davy; Fekete, Szabolcs
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Detection of busulfan adducts on proteinsAcosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; ... Lescuyer, Pierre
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Dynamic-Electromembrane Extraction: A Technical Development for the Extraction of NeuropeptidesDrouin, Nicolas; Rudaz, Serge; Schappler, Julie;
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Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in micePradal, Julie; Maudens, Pierre Marc Xavier; Gabay, Cem; Seemayer, Christian Alexander; ... Allémann, Eric
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Evaluation and identification of dioxin exposure biomarkers in human urine by high-resolution metabolomics, multivariate analysis and in vitro synthesisJeanneret, Fabienne; Tonoli, David; Hochstrasser, Denis; Saurat, Jean-Hilaire; ... Rudaz, Serge
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Evaluation of a new low sheath–flow interface for CE-MSGonzalez Ruiz, Victor; Codesido Sanchez, Santiago; Far, Johann; Rudaz, Serge; Schappler, Julie
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Evaluation of innovative stationary phase ligand chemistries and analytical conditions for the analysis of basic drugs by supercritical fluid chromatographyDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;
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Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling MethodBosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
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Evaluation of Quantification Methods to Compensate for Matrix Effects in the Analysis of Benzalkonium Chloride and Didecyldimethylammonium Chloride in Fruits and Vegetables by LC-ESI-MS/MSDiez, Cristina; Feinberg, Max; Staub Spörri, Aline; Cognard, Emmanuel; ... Rudaz, Serge
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Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbationsJeanneret, Fabienne; Tonoli, David; Rossier, Michel; Saugy, Martial; ... Rudaz, Serge
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Evaluation of thermally pretreated silica stationary phases under hydrophilic interaction chromatography conditionsMignot, Mélanie; Periat, Aurélie Claudine; Peulon-Agasse, Valérie; Cardinael, Pascal; ... Guillarme, Davy
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Exploring Omics data from designed experiments using analysis of variance multiblock Orthogonal Partial Least SquaresBoccard, Julien; Rudaz, Serge;
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Fast and sensitive supercritical fluid chromatography – tandem mass spectrometry multi-class screening method for the determination of doping agents in urineNováková, Lucie; Desfontaine, Vincent; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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High-throughput identification of monoclonal antibodies after compounding by UV spectroscopy coupled to chemometrics analysisJacoulet, Emmanuel; Boccard, Julien; Taverna, Myriam; Santos Azevedos, Andrea; ... Smadja, Claire
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part IGuillarme, Davy; Veuthey, Jean-Luc;
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Hydrophobic interaction chromatography for the characterization ofmonoclonal antibodies and related productsFekete, Szabolcs; Veuthey, Jean-Luc; Beck, Alain; Guillarme, Davy;
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Impact of organic modifier and temperature on protein denaturationin hydrophobic interaction chromatographyBobaly, Balazs; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Importance of vial shape and type on the reproducibility of sizeexclusion chromatography measurement of monoclonal antibodiesRodriguez Aller, Marta Ruth; Cusumano, Alessandra; Beck, Alain; Guillarme, Davy;
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In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhASlepikas, Liudas; Chiriano, Gianpaolo; Perozzo, Remo; Tardy, Sébastien; ... Scapozza, Leonardo
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cellsMarsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
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Korszerű méretkizáráso kromatográfia: fehérje aggregátumok elválasztásaFekete, Szabolcs; Fekete, Jenö; Guillarme, Davy;
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Liquid chromatography and supercritical fluid chromatography as alternative techniques to gas chromatography for the rapid screening of anabolic agents in urineDesfontaine, Vincent; Nováková, Lucie; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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Longitudinal monitoring of endogenous steroids in human serum by UHPLC-MS/MS as a tool to detect testosterone abuse in sportsPonzetto, Federico; Mehl, Florence; Boccard, Julien; Baume, Norbert; ... Nicoli, Raul
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Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anestheticsIng Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
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Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasiaMylonaki, Ioanna; Strano, Francesco; Deglise, Sebastien; Allémann, Eric; ... Delie Salmon, Florence
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Pharmacogenomics of Oral Antithrombotic DrugsStorelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre
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Potential of hydrophilic interaction chromatography for the analyticalcharacterization of protein biopharmaceuticalsPeriat, Aurélie Claudine; Fekete, Szabolcs; Cusumano, Alessandra; Veuthey, Jean-Luc; ... Guillarme, Davy
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Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatoraphy, part 2: Optimization of the phase systemCusumano, Alessandra; Guillarme, Davy; Beck, Alain; Fekete, Szabolcs;
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Prediction of retention time in reversed-phase liquid chromatography as a tool for steroid identificationRandazzo, Giuseppe Marco; Tonoli, David; Hambye, Stéphanie; Guillarme, Davy; ... Rudaz, Serge
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Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)Petit, Charlotte; Bujard, Alban; Skalicka-Woźniak, Krystyna; Cretton, Sylvian; ... Wolfender, Jean-Luc
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Preparative Scale MS-Guided Isolation of Bioactive Compounds Using High-Resolution Flash Chromatography: Antifungals from Chiloscyphus polyanthos as a Case StudyAzzollini, Antonio; Favre-Godal, Quentin; Zhang, Jiaozhen; Marcourt, Laurence; ... Wolfender, Jean-Luc
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Prescriptions médicamenteuses potentiellement inappropriées en gériatrie: quels outils utiliser pour les détecter?Desnoyer, Aude; Guignard, Bertrand; Lang, Pierre-Olivier; Desmeules, Jules Alexandre; ... Bonnabry, Pascal
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Prototype sphere-on-sphere silica particles for the separation of large biomoleculesFekete, Szabolcs; Rodriguez Aller, Marta Ruth; Cusumano, Alessandra; Hayes, Richard; ... Guillarme, Davy
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Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic DefectIng Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora
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Separation of substrates and closely related glucuronide metabolites using various chromatographic modesRomand, Stéphanie Anne; Rudaz, Serge; Guillarme, Davy;
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Snapshot of the prescribing practice for the clopidogrel and esomeprazole coprescription and cost evaluation of the application guidelinesVernaz-Hegi, Nathalie; Rollason Gumprecht, Victoria; Adlere, Liene; Combescure, Christophe; ... Desmeules, Jules Alexandre
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Statistical Correlations between HPLC Activity-Based Profiling Results and NMR/MS Microfraction Data to Deconvolute Bioactive Compounds in MixturesBertrand, Samuel; Azzollini, Antonio; Nievergelt-Meier, Andreas; Boccard, Julien; ... Wolfender, Jean-Luc
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Stratégies analytiques pour les contrôles antidopage : besoins, challenges et perspectivesNicoli, Raul; Guillarme, Davy; Leuenberger, Nicolas; Baume, Norbert; ... Veuthey, Jean-Luc
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Systematic evaluation of matrix effects in hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometryPeriat, Aurélie Claudine; Kohler, Isabelle; Thomas, Aurélien; Nicoli, Raul; ... Guillarme, Davy
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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesiaRalvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie
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Ultra-high performance supercritical fluid chromatography coupled with quadrupole-time-of-flight mass spectrometry as a performingtool for bioactive analysisGrand-Guillaume-Perrenoud, Alexandre; Guillarme, Davy; Boccard, Julien; Veuthey, Jean-Luc; ... Moco, Sofia

Book Chapters

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Capillary Electrophoresis-Ultraviolet-Mass Spectrometry (CE-UV-MS) for the Simultaneous Determination and Quantification of Insulin FormulationsSchappler, Julie; Rudaz, Serge;
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CE-MS in Drug Analysis and BioanalysisSchappler, Julie; Gonzalez Ruiz, Victor; Rudaz, Serge;

Doctoral Thesis

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1,4-Benzoxazin-3-ones at the metabolic interface between plants and insectsMaag, Daniel;
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Accurate mass spectral libraries and predicted liquid chromatography retention times in bioanalysis and data independent metabolomicsBruderer, Tobias;
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Anti-angiogenic strategies for chemoembolization of liver tumorsFuchs, Katrin;
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Blood proteome characterization of the interplay between glycation and aspirin-mediated acetylation in vitro and in diabetic patientsFinamore, Francesco;
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Development of contrast agents for imaging amyloids in type 2 diabetes – from chemical synthesis to in vivo trialsStransky-Heilkron, Nathalie Martine;
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Development of innovative strategies for the discovery of new antifungals from natural sources and in-depth investigations of their bioactivity profilesFavre-Godal, Quentin;
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EZH2 induces methylation of ERG enhancing its transcriptional and transforming activityCurti, Laura;
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HDAC inhibitors from natural and synthetic libraries: towards the development of biochemical probesZwick, Vincent;
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Human fetal progenitor tenocytes for the treatment of tendon afflictionsGrognuz, Anthony;
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In silico-driven strategies for the identification of novel sirtuin modulatorsSacconnay, Lionel;
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Mass spectrometry-based selectivity and sensitivity enhancement for the quantification of protein expression changes in anti-viral response mechanismsAlghanem, Bandar;
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Non-covalent PEGylation of therapeutic proteinsReichert, Christian;
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Nouvelles approches in vitro pour l'étude de la physico-chimie et du métabolisme de phase II de composés pharmaceutiquesRomand, Stéphanie Anne;
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The use of Internet for health information by hospitalized patients in Switzerland and QatarJesaimani, Ameena;
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Towards a prediction of intestinal absorption of medicinal plant constituents with the PAMPA permeability assayPetit, Charlotte;
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Venomics to decrypt the biomedical potential of spider toxinsOldrati, Vera Wanda;

2015

Scientific Articles

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A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapyKaderli, Sema Gwendolyn; Boulocher, C; Pillet, Eric François Alfred; Watrelot-Virieux, D; ... Jordan, Olivier
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A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-upDerfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
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A subsetofN-substituted phenothiazines inhibits NADPH oxidasesSeredenin, Tamara; Chiriano, Gianpaolo; Filippova, Aleksandra; Nayernia, Zeynab; ... Jaquet, Vincent
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Adrenergic antagonists restrict replication of LegionellaHarrison, Christopher F; Kicka, Sébastien; Kranjc Pietrucci, Agata; Finsel, Ivo; ... Hilbi, Hubert
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Aminoglycoside analysis in food of animal origin with a zwitterionic stationary phase and liquid chromatography–tandem mass spectrometryDiez, Cristina; Guillarme, Davy; Staub Sporri, Aline; Cognard, Emmanuelle; ... Rudaz, Serge
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Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophilaHarrison, Christopher F.; Chiriano, Gianpaolo; Finsel, Ivo; Manske, Christian; ... Hilbi, Hubert
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Assessing the affective load in the narratives of women suffering from fibromyalgia: the clinicians' appraisalCedraschi, Christine; Girard, Elodie Laure; Piguet, Valérie; Desmeules, Jules Alexandre; Allaz, Anne-Françoise
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Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic TreatmentsSaigi-Morgui, Núria; Vandenberghe, Frederik; Delacrétaz, Aurélie; Quteineh, Lina; ... Eap, Chin Bin
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Associations of ambulatory blood pressure with urinary caffeine and caffeine metabolite excretionsGuessous, Idris; Pruijm, Menno; Ponte, Belen; Ackermann, Daniel; ... Bochud, Murielle
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Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort studyCsaki Huttner, Angela; Von Dach, Elodie; Renzoni, Adriana Maria; Huttner, Benedikt; ... Harbarth, Stéphan Juergen
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Cannabinoïdes médicaux dans les douleurs chroniques : aspects pharmacologiquesIng Lorenzini, Kuntheavy; Broers, Barbara; Lalive d'Epinay, Patrice; Dayer, Pierre; ... Piguet, Valérie
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Chitosan as a starting material for wound healing applicationsPatrulea, Viorica; Ostafe, V.; Borchard, Gerrit; Jordan, Olivier;
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Comparison of fractionation strategies for offline two-dimensional liquid chromatography tandem mass spectrometry analysis of proteins from mouse adipose tissueSajic, Tatjana; Varesio, Emmanuel; Denes Carpentier, Ildiko; Hopfgartner, Gerard;
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