Section des sciences pharmaceutiques

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2018

Scientific Articles

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5-Aminolevulinic Acid-Squalene Nanoassemblies for Tumor Photodetection and Therapy: In Vitro StudiesBabic, Andréj; Herceg, Viktorija; Bastien, E.; Lassalle, H.-P.; ... Lange, Norbert
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Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?D'Atri, Valentina; Causson, Tim; Hernandez-Alba, Oscar; Mutabazi, Aline; ... Guillarme, Davy
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An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug ConjugatesEhkirch, Antony; D'Atri, Valentina; Rouviere, Florent; Hernandez-Alba, Oscar; ... Cianferani, Sarah
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Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targetsTrofimov, Valentin; Kicka, Sébastien; Mucaria, Sabrina; Hanna, Nabil; ... Soldati, Thierry
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Characterization of an antibody-drug conjugate by hydrophilic interaction chromatography coupled to mass spectrometryD'Atri, Valentina; Fekete, Szabolcs; Stoll, Dwight; Lauber, Matthew; ... Guillarme, Davy
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Consensus guidelines for the use and interpretation of angiogenesis assaysNowak-Sliwinska, Patrycja; Alitalo, Kari; Allen, Elizabeth; Anisimov, Andrey; ... Griffioen, Arjan W
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Current possibilities of liquid chromatography for the characterization of antibody-drug conjugatesBobaly, Balazs; Fleury, Sandrine; Beck, Alain; Veuthey, Jean-Luc; ... Fekete, Szabolcs
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Design and characterization of a perivascular PLGA coated PET mesh sustaining the release of atorvastatin for the prevention of intimal hyperplasiaMylonaki, Ioanna; Trosi, Orio; Allémann, Eric; Durand, Marlène; ... Delie Salmon, Florence
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Design, synthesis and in vitro evaluation of β-glucuronidase-sensitive prodrug of 5-aminolevulinic acid for photodiagnosis of breast cancer cellsHerceg, Viktorija; Adriouach, Souad; Janikowska, Karolina; Allémann, Eric; ... Babic, Andréj
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Determination of 16 antineoplastic drugs by capillary electrophoresis with UV detection: Applications in quality controlGuichard, Nicolas; Ogereau, Marie; Falaschi, Ludivine; Rudaz, Serge; ... Fleury-Souverain, Sandrine
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Development of a lc–ms/ms method for the determination of isomeric glutamyl peptides in food ingredientsDesfontaine, Vincent; Goyon, Alexandre; Veuthey, Jean-Luc; Charve, Joséphine; Guillarme, Davy
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Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic AntibodiesStoll, Dwight R.; Harmes, David C.; Staples, Gregory O.; Potter, Oscar G.; ... Beck, Alain
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Extending the limits of size exclusion chromatography: Simultaneousseparation of free payloads and related species from antibody drugconjugates and their aggregatesGoyon, Alexandre; Sciascera, Luca; Clarke, Adrien; Guillarme, Davy; Pell, Reinhard
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Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related productsEhkirch, Antony; Hernandez-Alba, Oscar; Colas, Olivier; Guillarme, Davy; Cianférani, Sarah
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Implementation of a generic liquid chromatographic methoddevelopment workflow: Application to the analysis ofphytocannabinoids and Cannabis sativa extractsFekete, Szabolcs; Sadat-Noorbakhsh, Vida; Schelling, Cédric; Molnar, Imre; ... Veuthey, Jean-Luc
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Improved separation by at-column dilution in preparative hydrophilicinteraction chromatographyJaffuel, Geoffrey; Chappuis, Laura; Guillarme, Davy; Turlings, Ted C.J.; Glauser, Gaétan
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Influence of connection tubing in modern size exclusionchromatography and its impact on the characterization of mAbsFekete, Szabolcs; Guillarme, Davy;
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Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteasesMukherjee, Budhaditya; Tessaro, Francesca; Vahokoski, Juha; Kursula, Inari; ... Soldati-Favre, Dominique
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Monoclonal antibody N-glycosylation profiling using capillary electrophoresis – Mass spectrometry: Assessment and method validationGiorgetti, Jérémie; D'Atri, Valentina; Canonge, Julie; Lechner, Antony; ... François, Yannis-Nicolas
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Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis TreatmentMaudens, Pierre Marc Xavier; Seemayer, Christian Alexander; Thauvin, Cédric; Gabay, Cem; ... Allémann, Eric
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Natural compounds analysis using liquid and supercritical fluid chromatography hyphenated to mass spectrometry: Evaluation of a new design of atmospheric pressure ionization sourceCiclet, Olivier; Barron, Denis; Bajic, Steve; Veuthey, Jean-Luc; ... Grand-Guillaume-Perrenoud, Alexandre
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Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulationWidmer, Jérôme; Thauvin, Cédric; Mottas, Inès; Nguyen, Van Nga; ... Bourquin, Carole
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Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp softwareMarsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
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Pseudomonas aeruginosa zinc homeostasis: Key issues for an opportunistic pathogenGonzalez, Manuel; Ducret, Verena; Leoni, Sara; Perron, Karl;
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Sample preparation for polar metabolites in bioanalysisDrouin, Nicolas; Rudaz, Serge; Schappler, Julie;
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Self-Assembled Nanomicelles as MRI Blood-Pool Contrast AgentBabic, Andréj; Vorobiev, Vassily; Xayaphoummine, Céline; Lapicorey, Gaëlle; ... Allémann, Eric
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Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapyMaudens, Pierre Marc Xavier; Meyer, Sophie; Seemayer, Christian Alexander; Jordan, Olivier; Allémann, Eric
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Size Exclusion Chromatography of Protein Biopharmaceuticals: Past, Present and FutureFekete, Szabolcs; Goyon, Alexandre; Veuthey, Jean-Luc; Guillarme, Davy;
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Survey on medicinal plants traditionally used in Senegal for the treatment of tuberculosis (TB) and assessment of their antimycobacterial activityDiop, ElHadji Assane; Queiroz, Emerson Ferreira; Kicka, Sébastien; Rudaz, Serge; ... Wolfender, Jean-Luc
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Systematic evaluation of matrix effects in supercritical fluid chromatography versus liquid chromatography coupled to mass spectrometry for biological samplesDesfontaine, Vincent; Capetti, France4sca; Nicoli, Raul; Kuuranne, Tiia; ... Guillarme, Davy
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Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound ExudatesGonzalez, Manuel; Ducret, Verena; Leoni, Sara; Fleuchot, Betty; ... Perron, Karl
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Utility of a high coverage phenyl-bonding and wide-pore superficially porous particle for the analysis of monoclonal antibodies and relatedproductsBobaly, Balazs; Lauber, Matthew; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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What are the current solutions for interfacing supercritical fluid chromatography and mass spectrometry?Guillarme, Davy; Desfontaine, Vincent; Heinisch, Sabine; Veuthey, Jean-Luc;

Doctoral Thesis

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Blood biomarkers in acute brain injury disordersLagerstedt, Linnéa;
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Development of new chemical and physical strategies to enhance topical drug deliverySanter, Verena;
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Facteur humain, performance, sécurité et qualité: une association envisageable pour la production de chimiothérapie ?Carrez, Laurent;
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Nanoparticles for lymph node delivery of antigenic peptides or immunostimulants to improve cancer immunotherapyMottas, Inès;
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Non-Biological Complex Drugs (NBCDs): evaluation of critical quality attributes of iron sucrose and iron polymaltoseDi Francesco, Tiziana;
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Physical techniques to overcome the cutaneous barrier: how iontophoresis and fractional laser ablation change the delivery kinetics of drugsSinghal, Mayank;
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Targeting HDAC6 with chemical modulators: catalytic inhibition and beyondDeschamps, Nathalie;
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Therapeutic protein aggregates: biophysical characterization and in vitro modelisation of subcutaneous tissueGroell, Floriane;

2017

Scientific Articles

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"Late" Withdrawal Syndrome after Carbamazepine In Utero Exposure in a CYP2C9 Slow Metabolizer NewbornPassia, Evangelia; Rock, Nathalie; Pfister, Riccardo E; Ing Lorenzini, Kuntheavy; ... Samer, Caroline Flora
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A systematic investigation of sample diluents in modern supercritical fluid chromatographyDesfontaine, Vincent; Tarafder, Abhijit; Hill, Jason; Fairchild, Jacob; ... Guillarme, Davy
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A workflow for column interchangeability in liquid chromatographyusing modeling software and quality-by-design principlesKormany, Robert; Tamas, Katalin; Guillarme, Davy; Fekete, Szabolcs;
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Achievable separation performance and analysis time in current liquid chromatographic practice for monoclonal antibody separationsFekete, Szabolcs; Veuthey, Jean-Luc; Guillarme, Davy;
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Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell linesHerceg, Viktorija; Lange, Norbert; Allémann, Eric; Babic, Andréj;
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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical CompoundsGuillarme, Davy; Veuthey, Jean-Luc;
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Analysis of recombinant monoclonal antibodies in hydrophilicinteraction chromatography: A generic method developmentapproachBobaly, Balazs; D'Atri, Valentina; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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Analytical Characterization of BiopharmaceuticalsGuillarme, Davy;
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Antineoplastic drugs and their analysis: a state of the art reviewGuichard, Nicolas; Guillarme, Davy; Bonnabry, Pascal; Fleury-Souverain, Sandrine;
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Cancer chemopreventive activity of compounds isolated from Waltheria indicaMonteillier, Aymeric; Cretton, Sylvian; Ciclet, Olivier; Marcourt, Laurence; ... Cuendet Licea, Muriel
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Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenationGoyon, Alexandre; D'Atri, Valentina; Colas, Olivier; Fekete, Szabolcs; ... Guillarme, Davy
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?Van Hoesen, Kylie; Meynier, Sonia; Ribaux, Pascale Garlonne; Petignat, Patrick; ... Cohen, Marie-Benoîte
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Comprehensive study on the effects of sodium and potassiumadditives in size exclusion chromatographic separations of proteinbiopharmaceuticalsGoyon, Alexandre; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Computer-Assisted Method Development for Small and Large MoleculesFekete, Szabolcs; Kormàni, Robert; Guillarme, Davy;
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Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant propertiesDel Rio Sancho, Sergio; Cros, Cecile; Coutaz, Bethsabée; Cuendet Licea, Muriel; Kalia, Yogeshvar
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Development of a fast workflow to screen the charge variants of therapeutic antibodiesWagner-Rousset, Elsa; Fekete, Szabolcs; Morel-Chevillet, Laura; Colas, Olivier; ... Beck, Alain
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Development of a New Extraction Device Based on Parallel- Electromembrane ExtractionDrouin, Nicolas; Mandscheff, Jean François; Rudaz, Serge; Schappler, Julie;
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Epigenetic strategies to reverse drug resistance in heterogeneous multiple myelomaIssa, Mark Elia; Takhsha, Farnaz Sedigheh; Chirumamilla, Chandra Sekhar; Perez-Novo, Claudina; ... Cuendet Licea, Muriel
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ERE-dependent transcription and cell proliferation: Independency of these two processes mediated by the introduction of a sulfone function into the weak estrogen estrothiazineJacquot, Yves; Spaggiari, Dany; Schappler, Julie; Lesniewska, Eric; ... Leclercq, Guy
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Functionalized PLA polymers to control loading and/or release properties of drug-loaded nanoparticlesThauvin, Cédric; Schwarz, Bettina; Delie Salmon, Florence; Allémann, Eric;
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HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurementsBujard, Alban; Petit, Charlotte; Carrupt, Pierre-Alain; Rudaz, Serge; Schappler, Julie
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersCusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part 1Guillarme, Davy; Veuthey, Jean-Luc;
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Identification and Mode of Action of a Plant Natural Product Targeting Human Fungal PathogensDorsaz, Stéphane; Snäkä, Tiia; Favre-Godal, Quentin; Maudens, Pierre Marc Xavier; ... Sanglard, Dominique
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Indirect quantitative structure-retention relationship for steroid identification: A chemometric challenge at "Chimiométrie 2016"Randazzo, Giuseppe Marco; Vigneau, Evelyne; Courcoux, Philippe; Harrouet, Corentin; ... Rudaz, Serge
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Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host modelOuertatani, Hajer; Kicka, Sébastien; Chiriano, Gianpaolo; Harrison, Christopher F; ... Cosson, Pierre
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Long-term stability of ganciclovir in polypropylene containers at room temperatureGuichard, Nicolas; Bonnabry, Pascal; Rudaz, Serge; Fleury, Sandrine;
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Metabolomic analysis of urine samples by UHPLC-QTOF-MS: Impact of normalization strategiesGagnebin, Yoric; Tonoli, David; Lescuyer, Pierre; Ponte, Belen; ... Rudaz, Serge
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Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targetingPansieri, Jonathan; Plissonneau, Marie; Stransky-Heilkron, Nathalie Martine; Dumoulin, Mireille; ... Marquette, Christel
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Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137)Simoes Avello, Claudia; Bertrand, Philippe; Cuendet Licea, Muriel;
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Optimization of non-linear gradient in hydrophobic interaction chromatography for the analytical characterization of antibody-drug conjugatesBobaly, Balazs; Randazzo, Giuseppe Marco; Rudaz, Serge; Guillarme, Davy; Fekete, Szabolcs
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Optimized selection of liquid chromatography conditions for widerange analysis of natural compoundsPeriat, Aurélie Claudine; Guillarme, Davy; Veuthey, Jean-Luc; Boccard, Julien; ... Grand-Guillaume Perrenoud, Alexandre
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Pannexin1 links lymphatic function to lipid metabolism and atherosclerosisMolica, Filippo; Meens, Merlijn; Dubrot Armendariz, Juan; Ehrlich, Avigail; ... Kwak, Brenda
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Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical StudyPetit, Charlotte; Ceccarelli, Martina; Cretton, Sylvian; Houriet, Joëlle; ... Wolfender, Jean-Luc
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Perivascular medical devices and drug delivery systems: Making the right choicesMylonaki, Ioanna; Allémann, Eric; Saucy, François; Haefliger, Jacques-Antoine; ... Jordan, Olivier
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PIM-Check: development of an international prescription-screening checklist designed by a Delphi method for internal medicine patientsDesnoyer, Aude; Blanc, Anne-Laure; Pourcher, Valérie; Besson, Marie; ... Guignard, Bertrand
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Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus)Osorio Lujan, Suzanne; Habre, Walid; Daali, Youssef; Pan, Zhaoxin; Kronen, Peter W
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Protocols for the analytical characterization of therapeutic monoclonal antibodies. I - Non-denaturing chromatographic techniquesGoyon, Alexandre; D'Atri, Valentina; Bobaly, Balazs; Wagner-Rousset, Elsa; ... Guillarme, Davy
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Protocols for the analytical characterization of therapeutic monoclonal antibodies. II – Enzymatic and chemical sample preparationBobaly, Balazs; Goyon, Alexandre; D'Atri, Valentina; Colas, Olivier; ... Guillarme, Davy
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Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatographyDispas, Amandine; Desfontaine, Vincent; Andri, Bertyl; Lebrun, Pierre; ... Hubert, Philippe
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Reliability of chemotherapy preparation processes: Evaluating independent double-checking and computer-assisted gravimetric controlCarrez, Laurent; Bouchoud, Lucie; Fleury, Sandrine; Combescure, Christophe; ... Bonnabry, Pascal
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Separation of antibody drug conjugate species by RPLC: A genericmethod development approachFekete, Szabolcs; Molnar, Imre; Guillarme, Davy;
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Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometryKammeijer, Guinevere S.M.; Jansen, Bas C.; Kohler, Isabelle; Heemskerk, Anthonius A.M.; ... Wuhrer, Manfred
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Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assayGuichard, Nicolas; Bonnabry, Pascal; Rudaz, Serge; Fleury-Souverain, Sandrine;
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Staphylococcus aureus carriage at admission predicts early-onset pneumonia after burn traumaFournier, Anne; Voirol, Pierre; Krahenbuhl, Michel; Bonnemain, C-L; ... Que, Y-A
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Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroidsStrajhar, Petra; Tonoli, David; Jeanneret, Fabienne; Imhof ., Raphaella M; ... Odermatt, Alex
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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear UptakeFrancisco Hilário, Flaviane; Traoré, Mohamed Dit Mady; Zwick, Vincent; Berry, Laurence; ... Wong, Yung-Sing
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Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilisKlein-Júnior, Luiz C.; Cretton, Sylvian; Allard, Pierre-Marie; Genta-Jouve, Grégory; ... Henriques, Amélia T.
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Targeting Multiple Myeloma Cancer Stem Cells with Natural Products - Lessons from Other Hematological MalignanciesIssa, Mark Elia; Cretton, Sylvian; Cuendet Licea, Muriel;
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The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell TransplantationUppugunduri, Chakradhara Rao S; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; ... Ansari Djaberi, Marc Georges
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The importance of system band broadening in modern size exclusion chromatographyGoyon, Alexandre; Guillarme, Davy; Fekete, Szabolcs;
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The Revival of Supercritical Fluid Chromatography in Pharmaceutical AnalysisVeuthey, Jean-Luc;
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UHPLC, Part 2: BenefitsDong, Michael W.; Guillarme, Davy;
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UHPLC, Part II: BenefitsDong, Michael W.; Guillarme, Davy;
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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal ExtractsZwick, Vincent; Allard, Pierre-Marie; Ory, Lucie; Simoes Avello, Claudia; ... Cuendet Licea, Muriel
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Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized MedicineMarsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
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Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the futureDarwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; ... Rostami-Hodjegan, A
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[4]Helicene-Squalene Fluorescent Nanoassemblies for Specific Targeting of Mitochondria in Live-Cell ImagingBabic, Andréj; Pascal, Simon; Duwald, Romain; Moreau, Dimitri; ... Allémann, Eric
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