Section des sciences pharmaceutiques

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2018

Scientific Articles

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5-Aminolevulinic Acid-Squalene Nanoassemblies for Tumor Photodetection and Therapy: In Vitro StudiesBabic, Andréj; Herceg, Viktorija; Bastien, E.; Lassalle, H.-P.; ... Lange, Norbert
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Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?D'Atri, Valentina; Causson, Tim; Hernandez-Alba, Oscar; Mutabazi, Aline; ... Guillarme, Davy
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An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug ConjugatesEhkirch, Antony; D'Atri, Valentina; Rouviere, Florent; Hernandez-Alba, Oscar; ... Cianferani, Sarah
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Anti-inflammatory and antiproliferative diterpenoids from Plectranthus scutellarioidesCretton, Sylvian; Saraux, Noémie; Monteillier, Aymeric; Righi, Davide; ... Christen, Philippe
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Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targetsTrofimov, Valentin; Kicka, Sébastien; Mucaria, Sabrina; Hanna, Nabil; ... Soldati, Thierry
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Applicability of supercritical fluid chromatography–mass spectrometry to metabolomics. I – Optimization of separation conditions for the simultaneous analysis of hydrophilic and lipophilic substancesDesfontaine, Vincent; Losacco, Gioacchino Luca; Gagnebin, Yoric; Pezzatti, Julian; ... Guillarme, Davy
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Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain ModuleWang, Haibin; Lo, Wen-Ting; Vujičić Žagar, Andreja; Gulluni, Federico; ... Vadas, Oscar
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Characterization of an antibody-drug conjugate by hydrophilic interaction chromatography coupled to mass spectrometryD'Atri, Valentina; Fekete, Szabolcs; Stoll, Dwight; Lauber, Matthew; ... Guillarme, Davy
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Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical PerspectivesStorelli, Flavia; Samer, Caroline Flora; Reny, Jean-Luc; Desmeules, Jules Alexandre; Daali, Youssef
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Consensus guidelines for the use and interpretation of angiogenesis assaysNowak-Sliwinska, Patrycja; Kwak, Brenda;
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Current possibilities of liquid chromatography for the characterization of antibody-drug conjugatesBobaly, Balazs; Fleury, Sandrine; Beck, Alain; Veuthey, Jean-Luc; ... Fekete, Szabolcs
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Design and characterization of a perivascular PLGA coated PET mesh sustaining the release of atorvastatin for the prevention of intimal hyperplasiaMylonaki, Ioanna; Trosi, Orio; Allémann, Eric; Durand, Marlène; ... Delie Salmon, Florence
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Design, synthesis and in vitro evaluation of β-glucuronidase-sensitive prodrug of 5-aminolevulinic acid for photodiagnosis of breast cancer cellsHerceg, Viktorija; Adriouach, Souad; Janikowska, Karolina; Allémann, Eric; ... Babic, Andréj
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Determination of 16 antineoplastic drugs by capillary electrophoresis with UV detection: Applications in quality controlGuichard, Nicolas; Ogereau, Marie; Falaschi, Ludivine; Rudaz, Serge; ... Fleury-Souverain, Sandrine
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Development of a lc–ms/ms method for the determination of isomeric glutamyl peptides in food ingredientsDesfontaine, Vincent; Goyon, Alexandre; Veuthey, Jean-Luc; Charve, Joséphine; Guillarme, Davy
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Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic AntibodiesStoll, Dwight R.; Harmes, David C.; Staples, Gregory O.; Potter, Oscar G.; ... Beck, Alain
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Enzyme-mediated photoinactivation of Enterococcus faecalis using Rose Bengal-acetateManoil, Daniel; Lange, Norbert; Bouillaguet, Serge;
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Evaluating intimal hyperplasia under clinical conditionsMylonaki, Ioanna; Allain, Elisabeth; Strano, Francesco; Allémann, Eric; ... Saucy, François
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Extending the limits of size exclusion chromatography: Simultaneousseparation of free payloads and related species from antibody drugconjugates and their aggregatesGoyon, Alexandre; Sciascera, Luca; Clarke, Adrien; Guillarme, Davy; Pell, Reinhard
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Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomesStorelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
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Hyphenation of size exclusion chromatography to native ion mobility mass spectrometry for the analytical characterization of therapeutic antibodies and related productsEhkirch, Antony; Hernandez-Alba, Oscar; Colas, Olivier; Guillarme, Davy; Cianférani, Sarah
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Imaging the porous structure in the core of degrading PLGA microparticles: The effect of molecular weightMylonaki, Ioanna; Allémann, Eric; Delie Salmon, Florence; Jordan, Olivier;
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Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active MetabolitesMarsousi, Niloufar; Daali, Youssef; Fontana, Pierre; Reny, Jean-Luc; ... Samer, Caroline Flora
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Implementation of a generic liquid chromatographic methoddevelopment workflow: Application to the analysis ofphytocannabinoids and Cannabis sativa extractsFekete, Szabolcs; Sadat-Noorbakhsh, Vida; Schelling, Cédric; Molnar, Imre; ... Veuthey, Jean-Luc
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Improved separation by at-column dilution in preparative hydrophilicinteraction chromatographyJaffuel, Geoffrey; Chappuis, Laura; Guillarme, Davy; Turlings, Ted C.J.; Glauser, Gaétan
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Influence of connection tubing in modern size exclusionchromatography and its impact on the characterization of mAbsFekete, Szabolcs; Guillarme, Davy;
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Interleukin-6 and Type-I Collagen Production by Systemic Sclerosis Fibroblasts Are Differentially Regulated by Interleukin-17A in the Presence of Transforming Growth Factor-Beta 1Dufour, Aleksandra Maria; Alvarez, Montserrat; Russo, Barbara; Chizzolini, Carlo;
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Intranasal administration of resveratrol successfully prevents lung cancer in A/J miceMonteillier, Aymeric; Voisin, Aymone; Furrer, Pascal; Allémann, Eric; Cuendet Licea, Muriel
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Isolation and Antimicrobial Activity of Coumarin Derivatives from Fruits of Peucedanum luxurians TamamschWidelski, Jarosław; Luca, Simon Vlad; Skiba, Adrianna; Chinou, Ioanna; ... Skalicka-Wozniak, Krystyna
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Lung Cancer Chemopreventive Activity of Patulin Isolated from Penicillium vulpinumMonteillier, Aymeric; Allard, Pierre-Marie; Gindro, Katia; Wolfender, Jean-Luc; Cuendet Licea, Muriel
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Metabolomic spectral libraries for data-independent SWATH liquid chromatography mass spectrometry acquisitionBruderer, Tobias; Varesio, Emmanuel; Hidasi, Anita Orsolya; Duchoslav, Eva; ... Hopfgartner, Gerard
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Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteasesMukherjee, Budhaditya; Tessaro, Francesca; Vahokoski, Juha; Kursula, Inari; ... Soldati-Favre, Dominique
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Molecular oxygen loading in candidate theranostic droplets stabilized with biocompatible fluorinated surfactants: Particle size effect and application to in situ19F MRI mapping of oxygen partial pressureLorton, Orane; Hyacinthe, Jean-Noël; Desgranges, Stéphane; Gui Levy, Laura; ... Salomir, Rares Vincent
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Monoclonal antibody N-glycosylation profiling using capillary electrophoresis – Mass spectrometry: Assessment and method validationGiorgetti, Jérémie; D'Atri, Valentina; Canonge, Julie; Lechner, Antony; ... François, Yannis-Nicolas
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Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis TreatmentMaudens, Pierre Marc Xavier; Seemayer, Christian Alexander; Thauvin, Cédric; Gabay, Cem; ... Allémann, Eric
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Natural compounds analysis using liquid and supercritical fluid chromatography hyphenated to mass spectrometry: Evaluation of a new design of atmospheric pressure ionization sourceCiclet, Olivier; Barron, Denis; Bajic, Steve; Veuthey, Jean-Luc; ... Grand-Guillaume-Perrenoud, Alexandre
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New developments and possibilities of wide-pore superficially porous particle technology applied for the liquid chromatographic analysis of therapeutic proteinsBobaly, Balazs; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs;
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Novel Natural Products for Healthy Ageing from the Mediterranean Diet and Food Plants of Other Global Sources-The MediHealth ProjectWaltenberger, Birgit; Halabalaki, Maria; Schwaiger, Stefan; Adamopoulos, Nicolas; ... Stuppner, Hermann
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Polymer-based nanoparticles loaded with a TLR7 ligand to target the lymph node for immunostimulationWidmer, Jérôme; Thauvin, Cédric; Mottas, Inès; Nguyen, Van Nga; ... Bourquin, Carole
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Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp softwareMarsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
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Pseudomonas aeruginosa zinc homeostasis: Key issues for an opportunistic pathogenGonzalez, Manuel; Ducret, Verena; Leoni, Sara; Perron, Karl;
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Sample preparation for polar metabolites in bioanalysisDrouin, Nicolas; Rudaz, Serge; Schappler, Julie;
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Self-Assembled Nanomicelles as MRI Blood-Pool Contrast AgentBabic, Andréj; Vorobiev, Vassily; Xayaphoummine, Céline; Lapicorey, Gaëlle; ... Allémann, Eric
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Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapyMaudens, Pierre Marc Xavier; Meyer, Sophie; Seemayer, Christian Alexander; Jordan, Olivier; Allémann, Eric
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Separation of blood microsamples by exploiting sedimentation at the microscaleForchelet, D; Béguin, S; Sajic, T; Bararpour, N; ... Renaud, P
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Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case reportAebischer, Gaspard; Ing Lorenzini, Kuntheavy; Tomala, Simon; Desmeules, Jules Alexandre; ... Samer, Caroline Flora
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Size Exclusion Chromatography of Protein Biopharmaceuticals: Past, Present and FutureFekete, Szabolcs; Goyon, Alexandre; Veuthey, Jean-Luc; Guillarme, Davy;
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Steroid profiles in both blood serum and seminal plasma are not correlated and do not reflect sperm quality: Study on the male reproductive health of fifty young Swiss menZufferey, Fanny; Rahban, Rita; Garcia, Arnaud; Gagnebin, Yoric; ... Rossier, Michel F
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Structural design, synthesis and substituent effect of hydrazone-N-acylhydrazones reveal potent immunomodulatory agentsMeira, Cássio S; Dos Santos Filho, José Maurício; Sousa, Caroline C; Anjos, Pâmela S; ... Soares, Milena B P
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Survey on medicinal plants traditionally used in Senegal for the treatment of tuberculosis (TB) and assessment of their antimycobacterial activityDiop, ElHadji Assane; Queiroz, Emerson Ferreira; Kicka, Sébastien; Rudaz, Serge; ... Wolfender, Jean-Luc
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Systematic evaluation of matrix effects in supercritical fluid chromatography versus liquid chromatography coupled to mass spectrometry for biological samplesDesfontaine, Vincent; Capetti, France4sca; Nicoli, Raul; Kuuranne, Tiia; ... Guillarme, Davy
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Transcriptome Analysis of Pseudomonas aeruginosa Cultured in Human Burn Wound ExudatesGonzalez, Manuel; Ducret, Verena; Leoni, Sara; Fleuchot, Betty; ... Perron, Karl
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Unraveling the mysteries of modern size exclusion chromatography – the way to achieve confident characterization of therapeutic proteinsGoyon, Alexandre; Fekete, Szabolcs; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy
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Utility of a high coverage phenyl-bonding and wide-pore superficially porous particle for the analysis of monoclonal antibodies and relatedproductsBobaly, Balazs; Lauber, Matthew; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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What are the current solutions for interfacing supercritical fluid chromatography and mass spectrometry?Guillarme, Davy; Desfontaine, Vincent; Heinisch, Sabine; Veuthey, Jean-Luc;
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When the Safe Alternative Is Not That Safe: Tramadol Prescribing in ChildrenRodieux, Frédérique; Vutskits, Laszlo; Posfay Barbe, Clara; Habre, Walid; ... Samer, Caroline Flora
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Younger age and in situ duration of peripheral intravenous catheters were risk factors for extravasation in a retrospective paediatric studyFonzo-Christe, Caroline Cécile; Parron, A; Combescure, Christophe; Rimensberger, Peter; ... Bonnabry, Pascal

Doctoral Thesis

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Blood biomarkers in acute brain injury disordersLagerstedt, Linnéa;
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Cyclopeptidic-based protease-sensitive photosensitizer prodrugs for selective photodynamic therapyBouilloux, Jordan;
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Development of new chemical and physical strategies to enhance topical drug deliverySanter, Verena;
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Étude de plantes médicinales et contrôle de qualité des préparations utilisées dans le traitement de la tuberculose au SénégalDiop, El Hadji Assane;
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Facteur humain, performance, sécurité et qualité: une association envisageable pour la production de chimiothérapie ?Carrez, Laurent;
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Identification and analysis of the putative AMP-activated protein kinase (AMPK) in blood stream form of Trypanosoma bruceiAmbuehl, Chiara;
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In vitro reconstitution of Slm1 mediated TORC2 activationVegunta, Yogesh;
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Les données de santé: analyses statistiques descriptives, développement de modèles prédictifs et comparaisons internationales sur les affaires réglementaires du médicamentZeukeng Zebaze, Minette Joëlle;
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Medication Adherence to Antiretrovirals among HIV-infected adults in Lausanne, SwitzerlandKamal, Susan;
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Nanoparticles for lymph node delivery of antigenic peptides or immunostimulants to improve cancer immunotherapyMottas, Inès;
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Natural NF-κB inhibitors for lung cancer chemopreventionMonteillier, Aymeric;
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Non-Biological Complex Drugs (NBCDs): evaluation of critical quality attributes of iron sucrose and iron polymaltoseDi Francesco, Tiziana;
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Physical techniques to overcome the cutaneous barrier: how iontophoresis and fractional laser ablation change the delivery kinetics of drugsSinghal, Mayank;
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Targeted delivery of spironolactone for the treatment of cutaneous and ocular diseases involving mineralocorticoid receptor over-activationDahmana, Naoual;
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Targeting HDAC6 with chemical modulators: catalytic inhibition and beyondDeschamps, Nathalie;
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The use of modern supercritical fluid chromatography and supercritical fluid chromatography - mass spectrometry in pharmaceutical analysisDesfontaine, Vincent;
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Therapeutic protein aggregates: biophysical characterization and in vitro modelisation of subcutaneous tissueGroell, Floriane;

2017

Scientific Articles

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"Late" Withdrawal Syndrome after Carbamazepine In Utero Exposure in a CYP2C9 Slow Metabolizer NewbornPassia, Evangelia; Rock, Nathalie; Pfister, Riccardo; Ing Lorenzini, Kuntheavy; ... Samer, Caroline Flora
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A systematic investigation of sample diluents in modern supercritical fluid chromatographyDesfontaine, Vincent; Tarafder, Abhijit; Hill, Jason; Fairchild, Jacob; ... Guillarme, Davy
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A workflow for column interchangeability in liquid chromatographyusing modeling software and quality-by-design principlesKormany, Robert; Tamas, Katalin; Guillarme, Davy; Fekete, Szabolcs;
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Achievable separation performance and analysis time in current liquid chromatographic practice for monoclonal antibody separationsFekete, Szabolcs; Veuthey, Jean-Luc; Guillarme, Davy;
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Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell linesHerceg, Viktorija; Lange, Norbert; Allémann, Eric; Babic, Andréj;
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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical CompoundsGuillarme, Davy; Veuthey, Jean-Luc;
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Analysis of recombinant monoclonal antibodies in hydrophilicinteraction chromatography: A generic method developmentapproachBobaly, Balazs; D'Atri, Valentina; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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Analytical Characterization of BiopharmaceuticalsGuillarme, Davy;
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Antineoplastic drugs and their analysis: a state of the art reviewGuichard, Nicolas; Guillarme, Davy; Bonnabry, Pascal; Fleury-Souverain, Sandrine;
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Antioxidant and antibacterial activities and polyphenolic constituents of Helianthemum sessiliflorum PersBenabdelaziz, Imane; Marcourt, Laurence; Benkhaled, Mohammed; Wolfender, Jean-Luc; Haba, Hamada
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Cancer chemopreventive activity of compounds isolated from Waltheria indicaMonteillier, Aymeric; Cretton, Sylvian; Ciclet, Olivier; Marcourt, Laurence; ... Cuendet Licea, Muriel
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Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenationGoyon, Alexandre; D'Atri, Valentina; Colas, Olivier; Fekete, Szabolcs; ... Guillarme, Davy
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Circulating GRP78 antibodies from ovarian cancer patients: a promising tool for cancer cell targeting drug delivery system?Van Hoesen, Kylie; Meynier, Sonia; Ribaux, Pascale Garlonne; Petignat, Patrick; ... Cohen, Marie-Benoîte
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Comprehensive study on the effects of sodium and potassiumadditives in size exclusion chromatographic separations of proteinbiopharmaceuticalsGoyon, Alexandre; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Computer-Assisted Method Development for Small and Large MoleculesFekete, Szabolcs; Kormàni, Robert; Guillarme, Davy;
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Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant propertiesDel Rio Sancho, Sergio; Cros, Cecile; Coutaz, Bethsabée; Cuendet Licea, Muriel; Kalia, Yogeshvar
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Development of a fast workflow to screen the charge variants of therapeutic antibodiesWagner-Rousset, Elsa; Fekete, Szabolcs; Morel-Chevillet, Laura; Colas, Olivier; ... Beck, Alain
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Development of a New Extraction Device Based on Parallel- Electromembrane ExtractionDrouin, Nicolas; Mandscheff, Jean François; Rudaz, Serge; Schappler, Julie;
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Epigenetic strategies to reverse drug resistance in heterogeneous multiple myelomaIssa, Mark Elia; Takhsha, Farnaz Sedigheh; Chirumamilla, Chandra Sekhar; Perez-Novo, Claudina; ... Cuendet Licea, Muriel
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ERE-dependent transcription and cell proliferation: Independency of these two processes mediated by the introduction of a sulfone function into the weak estrogen estrothiazineJacquot, Yves; Spaggiari, Dany; Schappler, Julie; Lesniewska, Eric; ... Leclercq, Guy
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Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)Lloret-Linares, Célia; Daali, Youssef; Chevret, Sylvie; Nieto, Isabelle; ... Bellivier, Frank
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Functionalized PLA polymers to control loading and/or release properties of drug-loaded nanoparticlesThauvin, Cédric; Schwarz, Bettina; Delie Salmon, Florence; Allémann, Eric;
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HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurementsBujard, Alban; Petit, Charlotte; Carrupt, Pierre-Alain; Rudaz, Serge; Schappler, Julie
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersCusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part 1Guillarme, Davy; Veuthey, Jean-Luc;
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