Section des sciences pharmaceutiques

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2020

Scientific Articles

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A combined activation mechanism for the glucagon receptorMattedi, Giulio; Acosta-Gutiérrez, Silvia; Clark, Timothy; Gervasio, Francesco Luigi;
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Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principlesBrillatz, Théo; Jacmin, Maxime; Vougogiannopoulou, Konstantina; Petrakis, Eleftherios A.; ... Wolfender, Jean-Luc
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Applicability of Supercritical fluid chromatography–Mass spectrometry to metabolomics. II–Assessment of a comprehensive library of metabolites and evaluation of biological matricesLosacco, Gioacchino Luca; Ismail, Omar; Pezzatti, Julian; Gonzalez Ruiz, Victor; ... Guillarme, Davy
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Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysisCamperi, Julien; Guillarme, Davy; Lei, Ming; Stella, Cinzia;
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Bacterial cell cycle control by citrate synthase independent of enzymatic activityBerge, Matthieu; Pezzatti, Julian; Gonzalez Ruiz, Victor; Degeorges, Laurence; ... Viollier, Patrick
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Comprehensive Examination of the Mouse Lung Metabolome Following Mycobacterium tuberculosis Infection Using a Multiplatform Mass Spectrometry ApproachFernández-García, Miguel; Rey-Stolle, Fernanda; Boccard, Julien; Reddy, Vineel P.; ... Barbas, Coral
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Coupling non-denaturing chromatography to mass spectrometry for the characterization of monoclonal antibodies and related productsFarsang, Evelin; Guillarme, Davy; Veuthey, Jean-Luc; Beck, Alain; ... Fekete, Szabolcs
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Cultivar, site or harvest date: the gordian knot of wine terroirSchmidtke, L. M.; Antalick, G.; Šuklje, K.; Blackman, J. W.; ... Deloire, A.
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Cytotoxicity of a new tirucallane derivative isolated from Stereospermum acuminatissimum K. Schum stem barkLeutcha, Bosco Peron; Sema, Denis Kehdinga; Dzoyem, Jean Paul; Ayimele, Godfred Aponglen; ... Meli Lannang, Alain
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Determination of size variants by CE-SDS for approved therapeutic antibodies: Key implications of subclasses and light chain specificitiesWagner, Elsa; Colas, Olivier; Chenu, Stéphane; Goyon, Alexandre; ... Beck, Alain
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Development and validation of a chiral UHPLC-MS method for the analysis of cysteine enantiomers in biological samplesPucciarini, Lucia; Gonzalez Ruiz, Victor; Zangari, Josephine; Martinou, Jean-Claude; ... Rudaz, Serge
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Development of a 3D-LC/MS Workflow for Fast, Automated, and Effective Characterization of Glycosylation Patterns of Biotherapeutic ProductsCamperi, Julien; Dai, Lu; Guillarme, Davy; Stella, Cinzia;
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Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma TreatmentZoetemelk, Marloes; Ramzy, George Mourad; Rausch, Magdalena; Nowak-Sliwinska, Patrycja;
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Editorial for the special issue titled "Biopharmaceuticals 2020"Fekete, Szabolcs; Guillarme, Davy;
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Editorial for the virtual special issue SEP 2019Guillarme, Davy; West, Caroline;
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Electromembrane Extraction of Highly Polar Compounds: Analysis of Cardiovascular Biomarkers in PlasmaDrouin, Nicolas; Kloots, Tim; Schappler, Julie; Rudaz, Serge; ... Hankemeier, Thomas
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Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phaseMcCalley, David V.; Guillarme, Davy;
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Fast and Automated Characterization of Monoclonal Antibody Minor Variants from Cell Cultures by Combined Protein-A and Multidimensional LC/MS MethodologiesCamperi, Julien; Dai, Lu; Guillarme, Davy; Stella, Cinzia;
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From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodiesGoyon, Alexandre; Dai, Lu; Chen, Tao; Wei, Bingchuan; ... Stella, Cinzia
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Functional and computational genomics reveal unprecedented flexibility in stage-specific Toxoplasma metabolismKrishnan, Aarti; Kloehn, Joachim; Lunghi, Matteo; Chiappino-Pepe, Anush; ... Soldati-Favre, Dominique
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Glycan-Mediated Technology for Obtaining Homogeneous Site-Specific Conjugated Antibody-Drug Conjugates: Synthesis and Analytical Characterization by Using Complementary Middle-up LC/HRMS AnalysisDuivelshof, Bastiaan; Deslignière, Evolène; Hernandez-Alba, Oscar; Ehkirch, Anthony; ... D'Atri, Valentina
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Identification of anti-mycobacterium and anti-legionella compounds with potential distinctive structural scaffolds from an HD-PBL using phenotypic screens in amoebae host modelsHanna, Nabil; Kicka, Sébastien; Chiriano, Gianpaolo; Harrison, Christopher; ... Soldati, Thierry
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Identification of low-dose multidrug combinations for sunitinib-naive and pre-treated renal cell carcinomaRausch, Magdalena; Weiss, Andrea; Achkhanian, Joanna; Rotari, Andrei; Nowak-Sliwinska, Patrycja
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Impact of the column on effluent pH in cation exchange pH gradient chromatography, a practical studyFarsang, Evelin; Horváth, Krisztián; Beck, Alain; Wang, Qi; ... Fekete, Szabolcs
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Implementation of liquid chromatography–high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorialPezzatti, Julian; Boccard, Julien; Codesido, Santiago; Gagnebin, Yoric; ... Rudaz, Serge
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Improving selectivity and performing online on-column fractioning in liquid chromatography for the separation of therapeutic biopharmaceutical productsFekete, Szabolcs; Ritchie, Harald; Lawhorn, Jason; Veuthey, Jean-Luc; Guillarme, Davy
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Interlaboratory and Interplatform Study of Steroids Collision Cross Section by Traveling Wave Ion Mobility SpectrometryHernández-Mesa, Maykel; D'Atri, Valentina; Barknowitz, Gitte; Fanuel, Mathieu; ... Le Bizec, Bruno
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Metabolomics approach reveals disruption of metabolic pathways in the marine bivalve Mytilus galloprovincialis exposed to a WWTP effluent extractDumas, Thibaut; Bonnefille, Bénilde; Gomez, Elena; Boccard, Julien; ... Courant, Frédérique
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Non-invasive targeted iontophoretic delivery of cetuximab to skinLapteva, Maria; Sallam, Marwa A.; Goyon, Alexandre; Guillarme, Davy; ... Kalia, Yogeshvar
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Ocular Biodistribution of Spironolactone after a Single Intravitreal Injection of a Biodegradable Sustained-Release Polymer in RatsDahmana, Naoual; Kowalczuk, Laura; Gabriel, Doris; Behar-Cohen, Francine; ... Kalia, Yogeshvar
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Optimization for multidrug combinations: Challenges and perspectives in complex disordersNowak-Sliwinska, Patrycja;
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Optimized one-pot derivatization and enantioseparation of cysteine: Application to the study of a dietary supplementPucciarini, Lucia; Saluti, Giorgio; Galarini, Roberta; Carotti, Andrea; ... Sardella, Roccaldo
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Patient-Derived In Vitro Models for Drug Discovery in Colorectal CarcinomaRamzy, George Mourad; Koessler, Thibaud; Ducrey, Eloise; McKee, Thomas; ... Nowak-Sliwinska, Patrycja
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Platelet Transforming Growth Factor-β1 Induces Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6Balaphas, Alexandre; Meyer, Jérémy; Perozzo, Remo; Zeisser-Labouebe, Magali; ... Buehler, Leo Hans
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PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the Treatment of Ovarian Cancer: In Vitro and In Ovo AssessmentFraguas-Sánchez, Ana I.; Torres-Suárez, Ana I.; Cohen, Marie-Benoîte; Delie Salmon, Florence; ... Fernández-Carballido, Ana
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Profiling of anabolic androgenic steroids and selective androgen receptor modulators for interference with adrenal steroidogenesisPatt, Melanie; Beck, Katharina R.; Di Marco, Tobias; Jäger, Marie-Christin; ... Odermatt, Alex
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Programmed death, cells on the last train to gloryNowak-Sliwinska, Patrycja; Griffioen, Arjan W;
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Satisfaction and experiences of patients taking fingolimod and involved in a pharmacy-based patient support program in Switzerland — a qualitative studyBourdin, Aline; Dubois, Julie; Foley, Rose-Anna; Schluep, Myriam; ... Berger, Jérôme
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Semen endocannabinoids are correlated to sperm quality in a cohort of 200 young Swiss menZufferey, Fanny; Donzé, Nicolas; Rahban, Rita; Senn, Alfred Paul; ... Rossier, Michel
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Silver-Containing Titanium Dioxide Nanocapsules for Combating Multidrug-Resistant BacteriaHérault, Nelly; Wagner, Julia; Abram, Sarah-Luise; Widmer, Jérôme; ... Fromm, Katharina M
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Steroid profile analysis by LC-HRMS in human seminal fluidOlesti, Eulalia; Garcia, Arnaud; Rahban, Rita; Rossier, Michel; ... Rudaz, Serge
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Supercritical fluid chromatography–mass spectrometry in routine anti-doping analyses: Estimation of retention time variability under reproducible conditionsLosacco, Gioacchino Luca; Marconetto, Elisa; Nicoli, Raul; Kuuranne, Tiia; ... Guillarme, Davy
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Targeted cutaneous delivery of etanercept using Er:YAG fractional laser ablationDel Río-Sancho, Sergio; Lapteva, Maria; Sonaje, Kiran; Böhler, Christof; ... Kalia, Yogeshvar
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The CzcCBA efflux system requires the CadA P-type ATPase for timely expression upon zinc excess in pseudomonas aeruginosaDucret, Verena; Gonzalez, Manuel R.; Leoni, Sara; Valentini, Martina; Perron, Karl
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The steps to therapeutic drug monitoring: A structured approach illustrated with imatinibBuclin, Thierry; Thoma, Yann; Widmer, Nicolas; André, Pascal; ... Decosterd, Laurent
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Therapeutic drug monitoring of targeted anticancer protein kinase inhibitors in routine clinical use: A critical reviewCardoso, Evelina; Guidi, Monia; Blanchet, Benoît; Schneider Voirol, Marie Paule; ... Widmer, Nicolas
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Tissue Levels of Flurbiprofen in the Rat Plantar Heel after Short-Duration Topical Iontophoresis are Sufficient to Induce Pharmacodynamic Responses to Local Pain StimuliCai, Yilu; Zhou, Ye; Zhang, Peiyan; Kalia, Yogeshvar; ... Chen, Yong

Book Chapters

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Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion and ReductionWagner-Rousset, Elsa; Colas, Olivier; François, Yannis-Nicolas; Heinisch, Sabine; ... Beck, Alain

Doctoral Thesis

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Medicinal Plants to Treat Epilepsy: Discovery of Antiseizure Compounds by In Vivo Zebrafish Bioactivity-Guided IsolationBrillatz, Théo;
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Understanding the interactions of gold nanoparticles with B lymphocytes in vitro and in vivoHocevar, Sandra;

2019

Scientific Articles

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A fehérje-kromatográfia alapvető problémáiFekete, Szabolcs;
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A generic workflow for the characterization of therapeutic monoclonal antibodies—application to daratumumabDuivelshof, Bastiaan; Fekete, Szabolcs; Guillarme, Davy; D'Atri, Valentina;
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A scoring approach for multi-platform acquisition in metabolomicsPezzatti, Julian; Gonzalez Ruiz, Victor; Codesido Sanchez, Santiago; Gagnebin, Yoric; ... Rudaz, Serge
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Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activationMottas, Inès; Bekdemir, Ahmet; Cereghetti, Alessandra; Spagnuolo, Lorenzo; ... Bourquin, Carole
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An Integrative Multi-Omics Workflow to Address Multifactorial Toxicology ExperimentsGonzalez Ruiz, Victor; Schvartz, Domitille; Sandstrom Von Tobel, Jenny; Pezzatti, Julian; ... Rudaz, Serge
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Analytical strategies for the determination of amino acids: Past, present and future trendsFerre, Sabrina Myriam; Gonzalez Ruiz, Victor; Guillarme, Davy; Rudaz, Serge;
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Anti-angiogenic effects of crenolanib are mediated by mitotic modulation independently of PDGFR expressionBerndsen, Robert H; Castrogiovanni, Cédric; Weiss, Andrea; Rausch, Magdalena; ... Nowak-Sliwinska, Patrycja
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Anti-inflammatory and Quinone Reductase-Inducing Compounds from Beilschmiedia manniiAhoua, Angora Rémi Constant; Monteillier, Aymeric; Borlat, Frédéric; Ciclet, Olivier; ... Cuendet Licea, Muriel
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Anticorps monoclonaux biosimilairesBeck, Alain; Guillarme, Davy; Fleury-Souverain, Sandrine; Bodier-Montagutelli, Elsa; Respaud, Renaud
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Antimycobacterial activity in a single-cell infection assay of ellagitannins from Combretum aculeatum and their bioavailable metabolitesDiop, El Hadji Assane; Ferreira Queiroz, Emerson; Marcourt, Laurence; Kicka, Sébastien; ... Wolfender, Jean-Luc
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Apparent efficiency of serially coupled columns in gradient elution liquid chromatography: Extension to the combination of any column formatsCodesido Sanchez, Santiago; Rudaz, Serge; Guillarme, Davy; Horváth, Krisztián; Fekete, Szabolcs
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Az ultranagy-hatékonyságú folyadékkromatográfia határaiKormány, Róbert; Fekete, Szabolcs;
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CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodesRapp, Moritz; Wintergerst, Maximilian W M; Kunz, Wolfgang G; Vetter, Viola K; ... Anz, David
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Characterization of charge variants for antibody-based biopharmaceuticals by mass spectrometryGuillarme, Davy; Hage, David S.;
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Chemical Composition and Anti-Inflammatory Activity of the Decoction from Leaves of a Cultivated Specimen of Myracrodruon urundeuvaAquino, Nayara; Ferreira Queiroz, Emerson; Marcourt, Laurence; Freitas, Lyara; ... Silveira, Edilberto
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Chemo-diversification of plant extracts using a generic bromination reaction and monitoring by metabolite profilingRighi, Davide; Marcourt, Laurence; Koval, Alexey; Ducret, Verena; ... Ferreira Queiroz, Emerson
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Choosing an Optimal Sample Preparation in Caulobacter crescentus for Untargeted Metabolomics ApproachesPezzatti, Julian; Berge, Matthieu; Boccard, Julien; Codesido Sanchez, Santiago; ... Rudaz, Serge
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Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and DasatinibBerndsen, Robert H; Swier, Nathalie; van Beijnum, Judy R; Nowak-Sliwinska, Patrycja;
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Combining the advantages of multilevel and orthogonal partial least squares data analysis for longitudinal metabolomics: Application to kidney transplantationGagnebin, Yoric; Pezzatti, Julian; Lescuyer, Pierre; Boccard, Julien; ... Rudaz, Serge
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Computer-assisted UHPLC–MS method development and optimization for the determination of 24 antineoplastic drugs used in hospital pharmacyGuichard, Nicolas; Fekete, Szabolcs; Guillarme, Davy; Bonnabry, Pascal; Fleury, Sandrine
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Controlled Iontophoretic Delivery in Vitro and in Vivo of ARN14140-A Multitarget Compound for Alzheimer's DiseaseSinghal, Mayank; Merino, Virginia; Rosini, Michela; Cavalli, Andrea; Kalia, Yogeshvar
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Cutaneous Biodistribution: A High-Resolution Methodology to Assess Bioequivalence in Topical Skin DeliveryQuartier, Julie; Capony, Ninon; Lapteva, Maria; Kalia, Yogeshvar;
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Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and futureBeck, Alain; D'Atri, Valentina; Ehkirch, Anthony; Fekete, Szabolcs; ... Cianférani, Sarah
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DDR1 role in fibrosis and its pharmacological targetingMoll, Solange; Desmoulière, Alexis; Moeller, Marcus J; Pache, Jean-Claude; ... Prunotto, Marco
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Development of a predictive score for potentially avoidable hospital readmissions for general internal medicine patientsBlanc, Anne-Laure; Fumeaux, Thierry; Stirnemann, Jérôme; Dupuis Lozeron, Elise; ... Bonnabry, Pascal
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Development of resiquimod-loaded modified PLA-based nanoparticles for cancer immunotherapy: A kinetic studyThauvin, Cédric; Widmer, Jérôme; Mottas, Inès; Hocevar, Sandra; ... Delie Salmon, Florence
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DNA and RNA telomeric G-quadruplexes: what topology features can be inferred from ion mobility mass spectrometry?D'Atri, Valentina; Gabelica, Valérie;
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Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancerNowak-Sliwinska, Patrycja; Scapozza, Leonardo; Ruiz Altaba, Ariel;
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Drug Transport across Porcine Intestine Using an Ussing Chamber System: Regional Differences and the Effect of P-Glycoprotein and CYP3A4 Activity on Drug AbsorptionArnold, Yvonne Elisabeth; Thorens, Julien; Bernard, Stéphane; Kalia, Yogeshvar;
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DynaStI: A Dynamic Retention Time Database for SteroidomicsCodesido Sanchez, Santiago; Randazzo, Giuseppe Marco; Lehmann, Fabio; Gonzalez Ruiz, Victor; ... Rudaz, Serge
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Effect of implantation site on outcome of tissue-engineered vascular graftsSologashvili, Tornike; Saat, Shahrul A; Tille, Jean-Christophe; De Valence De Minardiere, Sarra; ... Moeller, Michael
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Electromembrane extraction: Overview of the last decadeDrouin, Nicolas; Kubáň, Pavel; Rudaz, Serge; Pedersen-Bjergaard, Stig; Schappler, Julie
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Emergency and disaster preparedness of european hospital pharmacists: A surveySchumacher, Laurence; Bonnabry, Pascal; Widmer, Nicolas;
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Er:YAG fractional laser ablation for cutaneous co-delivery of pentoxifylline and d-α-tocopherol succinate: A new approach for topical treatment of radiation-induced skin fibrosisGou, Si; Del Rio Sancho, Sergio; Singhal, Mayank; Laubach, Han-Joachim; Kalia, Yogeshvar
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Fractional laser ablation for the targeted cutaneous delivery of an anti-CD29 monoclonal antibody - OS2966Lapteva, Maria; Del Río-Sancho, Sergio; Wu, Eric; Carbonell, W Shawn; ... Kalia, Yogeshvar N
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Genetic and clinic predictors of new onset diabetes mellitus after transplantationSaigi-Morgui, Núria; Quteineh, Lina; Bochud, Pierre-Yves; Crettol, Séverine; ... Eap, Chin Bin
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Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipientsQuteineh, Lina; Wójtowicz, Agnieszka; Bochud, Pierre-Yves; Crettol, Séverine; ... Eap, Chin Bin
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Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implicationsDuivelshof, Bastiaan; Jiskoot, Wim; Beck, Alain; Veuthey, Jean-Luc; ... D'Atri, Valentina
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Harnessing the immune system to fight cancer with Toll-like receptor and RIG-I-like receptor agonistsBourquin, Carole; Pommier, Aurélien; Hotz, Christian;
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Identification of a Synergistic Multi-Drug Combination Active in Cancer Cells via the Prevention of Spindle Pole ClusteringWeiss, Andrea; Le Roux-Bourdieu, Morgan; Zoetemelk, Marloes; Ramzy, George Mourad; ... Nowak-Sliwinska, Patrycja
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Impact of particle size gradients on the apparent efficiency of chromatographic columnsCodesido Sanchez, Santiago; Rudaz, Serge; Veuthey, Jean-Luc; Guillarme, Davy; ... Fekete, Szabolcs
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In Michael Moeller’s spiritDelie Salmon, Florence; Capelle, Martinus A.H.;
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In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db miceSandstrom Von Tobel, Jenny; Kratschmar, Denise V.; Broyer, Alexandra; Poirot, Olivier; ... Monnet-Tschudi, Florianne
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Innovative omics-based approaches for prioritisation and targeted isolation of natural products – new strategies for drug discoveryWolfender, Jean-Luc; Litaudon, Marc; Touboul, David; Ferreira Queiroz, Emerson;
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Is hydrophobic interaction chromatography the most suitable technique to characterize site-specific antibody-drug conjugates?D'Atri, Valentina; Pell, Reinhard; Clarke, Adrian; Guillarme, Davy; Fekete, Szabolcs
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Liquid Chromatography-Tandem Mass Spectrometry Method for Ticagrelor and its Active Metabolite Determination in Human Plasma: Application to a Pharmacokinetic StudyMarsousi, Niloufar; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef;
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Malignant ascites: a source of therapeutic protein against ovarian cancer?Ribaux, Pascale Garlonne; Britan, Aurore; Thumann, Gabriele; Delie Salmon, Florence; ... Cohen, Marie-Benoîte
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MRI micelles self-assembled from synthetic gadolinium-based nano building blocksBabic, Andréj; Vorobiev, Vassily; Trefalt, Gregor; Crowe, Lindsey; ... Allémann, Eric
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Optimization of MS-Compatible Mobile Phases for IEX Separation of Monoclonal AntibodiesFarsang, Evelin; Murisier, Amarande; Horvath, Krisztian; Colas, Olivier; ... Fekete, Szabolcs
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Optimization of MS-Compatible Mobile Phases for IEX Separation of Monoclonal AntibodiesFarsang, Evelin; Murisier, Amarande; Horvath, Krisztián; Colas, Olivier; ... Fekete, Szabolcs
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