Section des sciences pharmaceutiques

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2017

Scientific Articles

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A systematic investigation of sample diluents in modern supercritical fluid chromatographyDesfontaine, Vincent; Tarafder, Abhijit; Hill, Jason; Fairchild, Jacob; ... Guillarme, Davy
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Achievable separation performance and analysis time in current liquid chromatographic practice for monoclonal antibody separationsFekete, Szabolcs; Veuthey, Jean-Luc; Guillarme, Davy;
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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical CompoundsGuillarme, Davy; Veuthey, Jean-Luc;
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Analysis of recombinant monoclonal antibodies in hydrophilicinteraction chromatography: A generic method developmentapproachBobaly, Balazs; D'Atri, Valentina; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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Antineoplastic drugs and their analysis: a state of the art reviewGuichard, Nicolas; Guillarme, Davy; Bonnabry, Pascal; Fleury-Souverain, Sandrine;
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Cancer chemopreventive activity of compounds isolated from Waltheria indicaMonteillier, Aymeric; Cretton, Sylvian; Ciclet, Olivier; Marcourt, Laurence; ... Cuendet Licea, Muriel
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Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant propertiesDel Rio Sancho, Sergio; Cros, Cecile; Coutaz, Bethsabée; Cuendet Licea, Muriel; Kalia, Yogeshvar
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Development of a fast workflow to screen the charge variants of therapeutic antibodiesWagner-Rousset, Elsa; Fekete, Szabolcs; Morel-Chevillet, Laura; Colas, Olivier; ... Beck, Alain
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Development of a New Extraction Device Based on Parallel- Electromembrane ExtractionDrouin, Nicolas; Mandscheff, Jean François; Rudaz, Serge; Schappler, Julie;
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Epigenetic strategies to reverse drug resistance in heterogeneous multiple myelomaIssa, Mark Elia; Takhsha, Farnaz Sedigheh; Chirumamilla, Chandra Sekhar; Perez-Novo, Claudina; ... Cuendet Licea, Muriel
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HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurementsBujard, Alban; Petit, Charlotte; Carrupt, Pierre-Alain; Rudaz, Serge; Schappler, Julie
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersCusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part 1Guillarme, Davy; Veuthey, Jean-Luc;
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Indirect quantitative structure-retention relationship for steroid identification: A chemometric challenge at "Chimiométrie 2016"Randazzo, Giuseppe Marco; Vigneau, Evelyne; Courcoux, Philippe; Harrouet, Corentin; ... Rudaz, Serge
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Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137)Simoes Avello, Claudia; Bertrand, Philippe; Cuendet Licea, Muriel;
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Optimization of non-linear gradient in hydrophobic interaction chromatography for the analytical characterization of antibody-drug conjugatesBobaly, Balazs; Randazzo, Giuseppe Marco; Rudaz, Serge; Guillarme, Davy; Fekete, Szabolcs
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Optimized selection of liquid chromatography conditions for widerange analysis of natural compoundsPeriat, Aurélie Claudine; Guillarme, Davy; Veuthey, Jean-Luc; Boccard, Julien; ... Grand-Guillaume Perrenoud, Alexandre
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Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical StudyPetit, Charlotte; Ceccarelli, Martina; Cretton, Sylvian; Houriet, Joëlle; ... Wolfender, Jean-Luc
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Perivascular medical devices and drug delivery systems: Making the right choicesMylonaki, Ioanna; Allémann, Eric; Saucy, François; Haefliger, Jacques-Antoine; ... Jordan, Olivier
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Protocols for the analytical characterization of therapeutic monoclonal antibodies. II – Enzymatic and chemical sample preparationBobaly, Balazs; Goyon, Alexandre; D'Atri, Valentina; Colas, Olivier; ... Guillarme, Davy
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Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatographyDispas, Amandine; Desfontaine, Vincent; Andri, Bertyl; Lebrun, Pierre; ... Hubert, Philippe
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Separation of antibody drug conjugate species by RPLC: A genericmethod development approachFekete, Szabolcs; Molnar, Imre; Guillarme, Davy;
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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear UptakeFrancisco Hilário, Flaviane; Traoré, Mohamed Dit Mady; Zwick, Vincent; Berry, Laurence; ... Wong, Yung-Sing
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Targeting Multiple Myeloma Cancer Stem Cells with Natural Products - Lessons from Other Hematological MalignanciesIssa, Mark Elia; Cretton, Sylvian; Cuendet Licea, Muriel;
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The importance of system band broadening in modern size exclusion chromatographyGoyon, Alexandre; Guillarme, Davy; Fekete, Szabolcs;
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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal ExtractsZwick, Vincent; Allard, Pierre-Marie; Ory, Lucie; Simoes Avello, Claudia; ... Cuendet Licea, Muriel
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[4]Helicene-Squalene Fluorescent Nanoassemblies for Specific Targeting of Mitochondria in Live-Cell ImagingBabic, Andréj; Pascal, Simon; Duwald, Romain; Moreau, Dimitri; ... Allémann, Eric

Professional Articles

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Diagnostic des hémoglobinopathies par spectrométrie de masseCoelho Graca, Didia; Scherl, Alexander; Samii, Kaveh; Hochstrasser, Denis; Lescuyer, Pierre

Book Chapters

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Hyphenated Detectors: Mass SpectrometryDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;

Doctoral Thesis

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Modulation of epithelial tight junctions for barrier protection and drug deliveryRagupathy, Sakthikumar;
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Sustained release systems for the perivascular administration of atorvastatin to prevent vein graft failureMylonaki, Ioanna;
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Targeting the characteristics of multiple myeloma cancer stem cells with natural productsIssa, Mark Elia;

2016

Scientific Articles

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An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposureSpaggiari, Dany; Daali, Youssef; Rudaz, Serge;
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Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I − Optimization of separation conditionsSarrut, Morgane; Corgier, Amélie; Fekete, Szabolcs; Guillarme, Davy; ... Heinisch, Sabine
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Analysis of Riboflavin Compounds in the Rabbit Cornea In VivoHammer, Arthur; Rudaz, Serge; Guinchard, Sylvie; Kling, Sabine; ... Hafezi, Farhad
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Analytical Strategies for Doping Control Purposes: Needs, Challenges, and PerspectivesNicoli, Raul; Guillarme, Davy; Leuenberger, Nicolas; Baume, Norbert; ... Veuthey, Jean-Luc
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Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound BandagesAbdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; ... Applegate, Lee Ann
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Antifungal Quinoline Alkaloids from Waltheria indicaCretton, Sylvian; Dorsaz, Stéphane; Azzollini, Antonio; Favre-Godal, Quentin; ... Christen, Philippe
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Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruitsZeraik, Maria Luiza; Ferreira Queiroz, Emerson; Marcourt, Laurence; Ciclet, Olivier; ... Wolfender, Jean-Luc
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Arming embolic beads with anti-VEGF antibodies and controlling their release using LbL technologySakr, O S; Berndt, Sarah; Carpentier, G; Cuendet Licea, Muriel; ... Borchard, Gerrit
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Aspirin response: Differences in serum thromboxane B2 levels between clinical studiesBrun, Charlotte; Daali, Youssef; Combescure, Christophe; Zufferey Bakos, Anne; ... Frelinger, Andrew L (3rd)
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Best practice strategies to safeguard drug prescribing and drug administration: an anthology of expert views and opinionsSeidling, Hanna M; Stützle, Marion; Hoppe-Tichy, Torsten; Allenet, Benoît; ... Haefeli, Walter E
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Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activityCincinelli, Raffaella; Zwick, Vincent; Musso, Loana; Zuco, Valentina; ... Dallavalle, Sabrina
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Bruceantin inhibits multiple myeloma cancer stem cell proliferationIssa, Mark Elia; Berndt, Sarah; Carpentier, Gilles; Pezzuto, John M; Cuendet Licea, Muriel
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Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitorsZwick, Vincent; Simoes Avello, Claudia; Cuendet Licea, Muriel;
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Characterization of pDNA-TMC Nanoparticle Interaction and StabilityPoecheim, Johanna; Patrulea, Viorica; Reichert, Christian; Borchard, Gerrit;
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Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein BiopharmaceuticalsFekete, Szabolcs; Guillarme, Davy; Pat, Sandra; Koen, Sandra;
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approachMarsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
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Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometrySorensen, Matthew; Harmes, David C.; Stoll, Dwight R.; Staples, Gergory O.; ... Beck, Alain
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Computer assisted liquid chromatographic method development for the separation of therapeutic proteinsTyteca, Eva; Veuthey, Jean-Luc; Desmet, Gert; Guillarme, Davy; Fekete, Szabolcs
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Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamatesZwick, Vincent; Nurisso, Alessandra; Simoes Avello, Claudia; Bouchet, Samuel; ... Bertrand, Philippe
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Detection of busulfan adducts on proteinsAcosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; ... Lescuyer, Pierre
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Dynamic-Electromembrane Extraction: A Technical Development for the Extraction of NeuropeptidesDrouin, Nicolas; Rudaz, Serge; Schappler, Julie;
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Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in micePradal, Julie; Maudens, Pierre Marc Xavier; Gabay, Cem; Seemayer, Christian Alexander; ... Allémann, Eric
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Evaluation and identification of dioxin exposure biomarkers in human urine by high-resolution metabolomics, multivariate analysis and in vitro synthesisJeanneret, Fabienne; Tonoli, David; Hochstrasser, Denis; Saurat, Jean-Hilaire; ... Rudaz, Serge
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Evaluation of a new low sheath–flow interface for CE-MSGonzalez Ruiz, Victor; Codesido Sanchez, Santiago; Far, Johann; Rudaz, Serge; Schappler, Julie
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Evaluation of innovative stationary phase ligand chemistries and analytical conditions for the analysis of basic drugs by supercritical fluid chromatographyDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;
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Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling MethodBosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
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Evaluation of Quantification Methods to Compensate for Matrix Effects in the Analysis of Benzalkonium Chloride and Didecyldimethylammonium Chloride in Fruits and Vegetables by LC-ESI-MS/MSDiez, Cristina; Feinberg, Max; Staub Spörri, Aline; Cognard, Emmanuel; ... Rudaz, Serge
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Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbationsJeanneret, Fabienne; Tonoli, David; Rossier, Michel; Saugy, Martial; ... Rudaz, Serge
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Evaluation of thermally pretreated silica stationary phases under hydrophilic interaction chromatography conditionsMignot, Mélanie; Periat, Aurélie Claudine; Peulon-Agasse, Valérie; Cardinael, Pascal; ... Guillarme, Davy
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Exploring Omics data from designed experiments using analysis of variance multiblock Orthogonal Partial Least SquaresBoccard, Julien; Rudaz, Serge;
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Fast and sensitive supercritical fluid chromatography – tandem mass spectrometry multi-class screening method for the determination of doping agents in urineNováková, Lucie; Desfontaine, Vincent; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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High-throughput identification of monoclonal antibodies after compounding by UV spectroscopy coupled to chemometrics analysisJacoulet, Emmanuel; Boccard, Julien; Taverna, Myriam; Santos Azevedos, Andrea; ... Smadja, Claire
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part IGuillarme, Davy; Veuthey, Jean-Luc;
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Hydrophobic interaction chromatography for the characterization ofmonoclonal antibodies and related productsFekete, Szabolcs; Veuthey, Jean-Luc; Beck, Alain; Guillarme, Davy;
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Impact of organic modifier and temperature on protein denaturationin hydrophobic interaction chromatographyBobaly, Balazs; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Importance of vial shape and type on the reproducibility of sizeexclusion chromatography measurement of monoclonal antibodiesRodriguez Aller, Marta Ruth; Cusumano, Alessandra; Beck, Alain; Guillarme, Davy;
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In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhASlepikas, Liudas; Chiriano, Gianpaolo; Perozzo, Remo; Tardy, Sébastien; ... Scapozza, Leonardo
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cellsMarsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
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Korszerű méretkizáráso kromatográfia: fehérje aggregátumok elválasztásaFekete, Szabolcs; Fekete, Jenö; Guillarme, Davy;
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Liquid chromatography and supercritical fluid chromatography as alternative techniques to gas chromatography for the rapid screening of anabolic agents in urineDesfontaine, Vincent; Nováková, Lucie; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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Longitudinal monitoring of endogenous steroids in human serum by UHPLC-MS/MS as a tool to detect testosterone abuse in sportsPonzetto, Federico; Mehl, Florence; Boccard, Julien; Baume, Norbert; ... Nicoli, Raul
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Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anestheticsIng Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
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Perivascular sustained release of atorvastatin from a hydrogel-microparticle delivery system decreases intimal hyperplasiaMylonaki, Ioanna; Strano, Francesco; Deglise, Sebastien; Allémann, Eric; ... Delie Salmon, Florence
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Pharmacogenomics of Oral Antithrombotic DrugsStorelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre
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Potential of hydrophilic interaction chromatography for the analyticalcharacterization of protein biopharmaceuticalsPeriat, Aurélie Claudine; Fekete, Szabolcs; Cusumano, Alessandra; Veuthey, Jean-Luc; ... Guillarme, Davy
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Practical method development for the separation of monoclonal antibodies and antibody-drug-conjugate species in hydrophobic interaction chromatoraphy, part 2: Optimization of the phase systemCusumano, Alessandra; Guillarme, Davy; Beck, Alain; Fekete, Szabolcs;
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Prediction of retention time in reversed-phase liquid chromatography as a tool for steroid identificationRandazzo, Giuseppe Marco; Tonoli, David; Hambye, Stéphanie; Guillarme, Davy; ... Rudaz, Serge
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Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)Petit, Charlotte; Bujard, Alban; Skalicka-Woźniak, Krystyna; Cretton, Sylvian; ... Wolfender, Jean-Luc
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Preparative Scale MS-Guided Isolation of Bioactive Compounds Using High-Resolution Flash Chromatography: Antifungals from Chiloscyphus polyanthos as a Case StudyAzzollini, Antonio; Favre-Godal, Quentin; Zhang, Jiaozhen; Marcourt, Laurence; ... Wolfender, Jean-Luc
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Prescriptions médicamenteuses potentiellement inappropriées en gériatrie: quels outils utiliser pour les détecter?Desnoyer, Aude; Guignard, Bertrand; Lang, Pierre-Olivier; Desmeules, Jules Alexandre; ... Bonnabry, Pascal
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Prototype sphere-on-sphere silica particles for the separation of large biomoleculesFekete, Szabolcs; Rodriguez Aller, Marta Ruth; Cusumano, Alessandra; Hayes, Richard; ... Guillarme, Davy
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Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic DefectIng Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora
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Separation of substrates and closely related glucuronide metabolites using various chromatographic modesRomand, Stéphanie Anne; Rudaz, Serge; Guillarme, Davy;
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Snapshot of the prescribing practice for the clopidogrel and esomeprazole coprescription and cost evaluation of the application guidelinesVernaz-Hegi, Nathalie; Rollason Gumprecht, Victoria; Adlere, Liene; Combescure, Christophe; ... Desmeules, Jules Alexandre
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Statistical Correlations between HPLC Activity-Based Profiling Results and NMR/MS Microfraction Data to Deconvolute Bioactive Compounds in MixturesBertrand, Samuel; Azzollini, Antonio; Nievergelt-Meier, Andreas; Boccard, Julien; ... Wolfender, Jean-Luc
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Stratégies analytiques pour les contrôles antidopage : besoins, challenges et perspectivesNicoli, Raul; Guillarme, Davy; Leuenberger, Nicolas; Baume, Norbert; ... Veuthey, Jean-Luc
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Synthesis of a selective HDAC6 inhibitor active in neuroblastsZwick, Vincent; Simoes Avello, Claudia; Nurisso, Alessandra; Petit, Charlotte; ... Cuendet Licea, Muriel
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Systematic evaluation of matrix effects in hydrophilic interaction chromatography versus reversed phase liquid chromatography coupled to mass spectrometryPeriat, Aurélie Claudine; Kohler, Isabelle; Thomas, Aurélien; Nicoli, Raul; ... Guillarme, Davy
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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesiaRalvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie
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Ultra-high performance supercritical fluid chromatography coupled with quadrupole-time-of-flight mass spectrometry as a performingtool for bioactive analysisGrand-Guillaume-Perrenoud, Alexandre; Guillarme, Davy; Boccard, Julien; Veuthey, Jean-Luc; ... Moco, Sofia
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Withaferin A induces cell death and differentiation in multiple myeloma cancer stem cellsIssa, Mark Elia; Cuendet Licea, Muriel;

Book Chapters

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Capillary Electrophoresis-Ultraviolet-Mass Spectrometry (CE-UV-MS) for the Simultaneous Determination and Quantification of Insulin FormulationsSchappler, Julie; Rudaz, Serge;
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CE-MS in Drug Analysis and BioanalysisSchappler, Julie; Gonzalez Ruiz, Victor; Rudaz, Serge;

Doctoral Thesis

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1,4-Benzoxazin-3-ones at the metabolic interface between plants and insectsMaag, Daniel;
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A non-coding RNA network influenced by genetic polymorphism controls E-cadherin expression in human cancersPisignano, Giuseppina;
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A novel oncogenic axis involving the ETS factor ESE3/EHF, miR-424, COP1 and STAT3 drives prostate tumor progressionDallavalle, Cécilia;
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Accurate mass spectral libraries and predicted liquid chromatography retention times in bioanalysis and data independent metabolomicsBruderer, Tobias;
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