Section des sciences pharmaceutiques

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2017

Scientific Articles

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"Late" Withdrawal Syndrome after Carbamazepine In Utero Exposure in a CYP2C9 Slow Metabolizer NewbornPassia, Evangelia; Rock, Nathalie; Pfister, Riccardo E; Ing Lorenzini, Kuntheavy; ... Samer Fahem, Caroline Flora
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A systematic investigation of sample diluents in modern supercritical fluid chromatographyDesfontaine, Vincent; Tarafder, Abhijit; Hill, Jason; Fairchild, Jacob; ... Guillarme, Davy
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A workflow for column interchangeability in liquid chromatographyusing modeling software and quality-by-design principlesKORMANY, ROBERT; TAMAS, KATALIN; Guillarme, Davy; Fekete, Szabolcs;
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Achievable separation performance and analysis time in current liquid chromatographic practice for monoclonal antibody separationsFekete, Szabolcs; Veuthey, Jean-Luc; Guillarme, Davy;
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Activity of phosphatase-sensitive 5-aminolevulinic acid prodrugs in cancer cell linesHerceg, Viktorija; Lange, Norbert; Allémann, Eric; Babic, Andréj;
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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical CompoundsGuillarme, Davy; Veuthey, Jean-Luc;
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Analysis of recombinant monoclonal antibodies in hydrophilicinteraction chromatography: A generic method developmentapproachBobaly, Balazs; D'Atri, Valentina; Beck, Alain; Guillarme, Davy; Fekete, Szabolcs
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Analytical Characterization of BiopharmaceuticalsGuillarme, Davy;
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Antineoplastic drugs and their analysis: a state of the art reviewGuichard, Nicolas; Guillarme, Davy; Bonnabry, Pascal; Fleury-Souverain, Sandrine;
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Cancer chemopreventive activity of compounds isolated from Waltheria indicaMonteillier, Aymeric; Cretton, Sylvian; Ciclet, Olivier; Marcourt, Laurence; ... Cuendet Licea, Muriel
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Characterization of 30 therapeutic antibodies and related products by size exclusion chromatography: Feasibility assessment for future mass spectrometry hyphenationGoyon, Alexandre; D'Atri, Valentina; Colas, Olivier; Fekete, Szabolcs; ... Guillarme, Davy
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Comprehensive study on the effects of sodium and potassiumadditives in size exclusion chromatographic separations of proteinbiopharmaceuticalsGoyon, Alexandre; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Computer-Assisted Method Development for Small and Large MoleculesFekete, Szabolcs; Kormàni, Robert; Guillarme, Davy;
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Cutaneous iontophoresis of μ-conotoxin CnIIIC-A potent NaV1.4 antagonist with analgesic, anaesthetic and myorelaxant propertiesDel Rio Sancho, Sergio; Cros, Cecile; Coutaz, Bethsabée; Cuendet Licea, Muriel; Kalia, Yogeshvar
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Development of a fast workflow to screen the charge variants of therapeutic antibodiesWagner-Rousset, Elsa; Fekete, Szabolcs; Morel-Chevillet, Laura; Colas, Olivier; ... Beck, Alain
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Development of a New Extraction Device Based on Parallel- Electromembrane ExtractionDrouin, Nicolas; Mandscheff, Jean François; Rudaz, Serge; Schappler, Julie;
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Epigenetic strategies to reverse drug resistance in heterogeneous multiple myelomaIssa, Mark Elia; Takhsha, Farnaz Sedigheh; Chirumamilla, Chandra Sekhar; Perez-Novo, Claudina; ... Cuendet Licea, Muriel
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HDM-PAMPA to predict gastrointestinal absorption, binding percentage, equilibrium and kinetics constants with human serum albumin and using 2 end-point measurementsBujard, Alban; Petit, Charlotte; Carrupt, Pierre-Alain; Rudaz, Serge; Schappler, Julie
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane TransportersCusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part 1Guillarme, Davy; Veuthey, Jean-Luc;
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Indirect quantitative structure-retention relationship for steroid identification: A chemometric challenge at "Chimiométrie 2016"Randazzo, Giuseppe Marco; Vigneau, Evelyne; Courcoux, Philippe; Harrouet, Corentin; ... Rudaz, Serge
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Long-term stability of ganciclovir in polypropylene containers at room temperatureGuichard, Nicolas; Bonnabry, Pascal; Rudaz, Serge; Fleury, Sandrine;
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Metabolomic analysis of urine samples by UHPLC-QTOF-MS: Impact of normalization strategiesGagnebin, Yoric; Tonoli, David; Lescuyer, Pierre; Ponte, Belen; ... Rudaz, Serge
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Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targetingPansieri, Jonathan; Plissonneau, Marie; Stransky-Heilkron, Nathalie Martine; Dumoulin, Mireille; ... Marquette, Christel
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Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137)Simoes Avello, Claudia; Bertrand, Philippe; Cuendet Licea, Muriel;
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Optimization of non-linear gradient in hydrophobic interaction chromatography for the analytical characterization of antibody-drug conjugatesBobaly, Balazs; Randazzo, Giuseppe Marco; Rudaz, Serge; Guillarme, Davy; Fekete, Szabolcs
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Optimized selection of liquid chromatography conditions for widerange analysis of natural compoundsPeriat, Aurélie Claudine; Guillarme, Davy; Veuthey, Jean-Luc; Boccard, Julien; ... Grand-Guillaume Perrenoud, Alexandre
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Pannexin1 links lymphatic function to lipid metabolism and atherosclerosisMolica, Filippo; Meens, Merlijn; Dubrot Armendariz, Juan; Ehrlich, Avigail; ... Kwak, Brenda
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Passive Intestinal Absorption of Representative Plant Secondary Metabolites: A Physicochemical StudyPetit, Charlotte; Ceccarelli, Martina; Cretton, Sylvian; Houriet, Joëlle; ... Wolfender, Jean-Luc
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Perivascular medical devices and drug delivery systems: Making the right choicesMylonaki, Ioanna; Allémann, Eric; Saucy, François; Haefliger, Jacques-Antoine; ... Jordan, Olivier
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PIM-Check: development of an international prescription-screening checklist designed by a Delphi method for internal medicine patientsDesnoyer, Aude; Blanc, Anne-Laure; Pourcher, Valérie; Besson, Marie; ... Guignard, Bertrand
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Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus)Osorio Lujan, Suzanne; Habre, Walid; Daali, Youssef; Pan, Zhaoxin; Kronen, Peter W
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Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp softwareMarsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
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Protocols for the analytical characterization of therapeutic monoclonal antibodies. II – Enzymatic and chemical sample preparationBobaly, Balazs; Goyon, Alexandre; D'Atri, Valentina; Colas, Olivier; ... Guillarme, Davy
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Quantitative determination of salbutamol sulfate impurities using achiral supercritical fluid chromatographyDispas, Amandine; Desfontaine, Vincent; Andri, Bertyl; Lebrun, Pierre; ... Hubert, Philippe
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Separation of antibody drug conjugate species by RPLC: A genericmethod development approachFekete, Szabolcs; Molnar, Imre; Guillarme, Davy;
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Sialic acid linkage differentiation of glycopeptides using capillary electrophoresis – electrospray ionization – mass spectrometryKammeijer, Guinevere S.M.; Jansen, Bas C.; Kohler, Isabelle; Heemskerk, Anthonius A.M.; ... Wuhrer, Manfred
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Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assayGuichard, Nicolas; Bonnabry, Pascal; Rudaz, Serge; Fleury-Souverain, Sandrine;
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Synthesis of an Uncharged Tetra-cyclopeptide Acting as a Transmembrane Carrier: Enhanced Cellular and Nuclear UptakeFrancisco Hilário, Flaviane; Traoré, Mohamed Dit Mady; Zwick, Vincent; Berry, Laurence; ... Wong, Yung-Sing
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Targeting Multiple Myeloma Cancer Stem Cells with Natural Products - Lessons from Other Hematological MalignanciesIssa, Mark Elia; Cretton, Sylvian; Cuendet Licea, Muriel;
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The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell TransplantationUppugunduri, Chakradhara Rao S; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; ... Ansari Djaberi, Marc Georges
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The importance of system band broadening in modern size exclusion chromatographyGoyon, Alexandre; Guillarme, Davy; Fekete, Szabolcs;
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UHPLC, Part 2: BenefitsDong, Michael W.; Guillarme, Davy;
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UHPLC, Part II: BenefitsDong, Michael W.; Guillarme, Davy;
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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal ExtractsZwick, Vincent; Allard, Pierre-Marie; Ory, Lucie; Simoes Avello, Claudia; ... Cuendet Licea, Muriel
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Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized MedicineMarsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
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Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the futureDarwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; ... Rostami-Hodjegan, A
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[4]Helicene-Squalene Fluorescent Nanoassemblies for Specific Targeting of Mitochondria in Live-Cell ImagingBabic, Andréj; Pascal, Simon; Duwald, Romain; Moreau, Dimitri; ... Allémann, Eric

Professional Articles

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Diagnostic des hémoglobinopathies par spectrométrie de masseCoelho Graca, Didia; Scherl, Alexander; Samii, Kaveh; Hochstrasser, Denis; Lescuyer, Pierre
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Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host modelOuertatani, Hajer; Kicka, Sébastien; Chiriano, Gianpaolo; Harrison, Christopher F; ... Cosson, Pierre

Book Chapters

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Hyphenated Detectors: Mass SpectrometryDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;

Doctoral Thesis

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Biomarkers for prediction of cerebrovascular diseases associated complications and outcomeAzurmendi Gil, Leire;
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Modulation of epithelial tight junctions for barrier protection and drug deliveryRagupathy, Sakthikumar;
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Sustained release systems for the perivascular administration of atorvastatin to prevent vein graft failureMylonaki, Ioanna;
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Targeting the characteristics of multiple myeloma cancer stem cells with natural productsIssa, Mark Elia;

2016

Scientific Articles

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An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposureSpaggiari, Dany; Daali, Youssef; Rudaz, Serge;
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Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I − Optimization of separation conditionsSarrut, Morgane; Corgier, Amélie; Fekete, Szabolcs; Guillarme, Davy; ... Heinisch, Sabine
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Analysis of Riboflavin Compounds in the Rabbit Cornea In VivoHammer, Arthur; Rudaz, Serge; Guinchard, Sylvie; Kling, Sabine; ... Hafezi, Farhad
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Analytical Strategies for Doping Control Purposes: Needs, Challenges, and PerspectivesNicoli, Raul; Guillarme, Davy; Leuenberger, Nicolas; Baume, Norbert; ... Veuthey, Jean-Luc
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Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound BandagesAbdel-Sayed, Philippe; Kaeppli, Ariane; Siriwardena, Thissa; Darbre, Tamis; ... Applegate, Lee Ann
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Antifungal Quinoline Alkaloids from Waltheria indicaCretton, Sylvian; Dorsaz, Stéphane; Azzollini, Antonio; Favre-Godal, Quentin; ... Christen, Philippe
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Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruitsZeraik, Maria Luiza; Ferreira Queiroz, Emerson; Marcourt, Laurence; Ciclet, Olivier; ... Wolfender, Jean-Luc
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Arming embolic beads with anti-VEGF antibodies and controlling their release using LbL technologySakr, O S; Berndt, Sarah; Carpentier, G; Cuendet Licea, Muriel; ... Borchard, Gerrit
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Aspirin response: Differences in serum thromboxane B2 levels between clinical studiesBrun, Charlotte; Daali, Youssef; Combescure, Christophe; Zufferey Bakos, Anne; ... Frelinger, Andrew L (3rd)
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Best practice strategies to safeguard drug prescribing and drug administration: an anthology of expert views and opinionsSeidling, Hanna M; Stützle, Marion; Hoppe-Tichy, Torsten; Allenet, Benoît; ... Haefeli, Walter E
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Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activityCincinelli, Raffaella; Zwick, Vincent; Musso, Loana; Zuco, Valentina; ... Dallavalle, Sabrina
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Bon usage des antidépresseurs ISRS durant la grossesse – le défi de l’évaluation de la balance bénéfice-risqueWeisskopf, Etienne; Fumeaux, Céline J Fischer; Bickle Graz, Myriam; Harari, Mathild Morisod; ... Panchaud-Monnat, Alice
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Bruceantin inhibits multiple myeloma cancer stem cell proliferationIssa, Mark Elia; Berndt, Sarah; Carpentier, Gilles; Pezzuto, John M; Cuendet Licea, Muriel
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Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitorsZwick, Vincent; Simoes Avello, Claudia; Cuendet Licea, Muriel;
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Characterization of pDNA-TMC Nanoparticle Interaction and StabilityPoecheim, Johanna; Patrulea, Viorica; Reichert, Christian; Borchard, Gerrit;
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Chromatographic, Electrophoretic, and Mass Spectrometric Methods for the Analytical Characterization of Protein BiopharmaceuticalsFekete, Szabolcs; Guillarme, Davy; Pat, Sandra; Koen, Sandra;
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approachMarsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
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Comparison of originator and biosimilar therapeutic monoclonal antibodies using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometrySorensen, Matthew; Harmes, David C.; Stoll, Dwight R.; Staples, Gergory O.; ... Beck, Alain
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Computer assisted liquid chromatographic method development for the separation of therapeutic proteinsTyteca, Eva; Veuthey, Jean-Luc; Desmet, Gert; Guillarme, Davy; Fekete, Szabolcs
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Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamatesZwick, Vincent; Nurisso, Alessandra; Simoes Avello, Claudia; Bouchet, Samuel; ... Bertrand, Philippe
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Detection of busulfan adducts on proteinsAcosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; ... Lescuyer, Pierre
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Dynamic-Electromembrane Extraction: A Technical Development for the Extraction of NeuropeptidesDrouin, Nicolas; Rudaz, Serge; Schappler, Julie;
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Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in micePradal, Julie; Maudens, Pierre Marc Xavier; Gabay, Cem; Seemayer, Christian Alexander; ... Allémann, Eric
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Evaluation and identification of dioxin exposure biomarkers in human urine by high-resolution metabolomics, multivariate analysis and in vitro synthesisJeanneret, Fabienne; Tonoli, David; Hochstrasser, Denis; Saurat, Jean-Hilaire; ... Rudaz, Serge
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Evaluation of a new low sheath–flow interface for CE-MSGonzalez Ruiz, Victor; Codesido Sanchez, Santiago; Far, Johann; Rudaz, Serge; Schappler, Julie
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Evaluation of innovative stationary phase ligand chemistries and analytical conditions for the analysis of basic drugs by supercritical fluid chromatographyDesfontaine, Vincent; Veuthey, Jean-Luc; Guillarme, Davy;
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Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling MethodBosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
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Evaluation of Quantification Methods to Compensate for Matrix Effects in the Analysis of Benzalkonium Chloride and Didecyldimethylammonium Chloride in Fruits and Vegetables by LC-ESI-MS/MSDiez, Cristina; Feinberg, Max; Staub Spörri, Aline; Cognard, Emmanuel; ... Rudaz, Serge
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Evaluation of steroidomics by liquid chromatography hyphenated to mass spectrometry as a powerful analytical strategy for measuring human steroid perturbationsJeanneret, Fabienne; Tonoli, David; Rossier, Michel; Saugy, Martial; ... Rudaz, Serge
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Evaluation of thermally pretreated silica stationary phases under hydrophilic interaction chromatography conditionsMignot, Mélanie; Periat, Aurélie Claudine; Peulon-Agasse, Valérie; Cardinael, Pascal; ... Guillarme, Davy
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Exploring Omics data from designed experiments using analysis of variance multiblock Orthogonal Partial Least SquaresBoccard, Julien; Rudaz, Serge;
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Fast and sensitive supercritical fluid chromatography – tandem mass spectrometry multi-class screening method for the determination of doping agents in urineNováková, Lucie; Desfontaine, Vincent; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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Health On the Net's 20 Years of Transparent and Reliable Health InformationBoyer Walther, Célia; Appel, Ron David; Ball, Marion J; van Bemmel, Jan H; ... Geissbuhler, Antoine
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High-throughput identification of monoclonal antibodies after compounding by UV spectroscopy coupled to chemometrics analysisJacoulet, Emmanuel; Boccard, Julien; Taverna, Myriam; Santos Azevedos, Andrea; ... Smadja, Claire
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HPLC Teaching Assistant: A New Tool for Learning and Teaching Liquid Chromatography, Part IGuillarme, Davy; Veuthey, Jean-Luc;
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Hydrophobic interaction chromatography for the characterization ofmonoclonal antibodies and related productsFekete, Szabolcs; Veuthey, Jean-Luc; Beck, Alain; Guillarme, Davy;
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Impact of organic modifier and temperature on protein denaturationin hydrophobic interaction chromatographyBobaly, Balazs; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy; Fekete, Szabolcs
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Importance of vial shape and type on the reproducibility of sizeexclusion chromatography measurement of monoclonal antibodiesRodriguez Aller, Marta Ruth; Cusumano, Alessandra; Beck, Alain; Guillarme, Davy;
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In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhASlepikas, Liudas; Chiriano, Gianpaolo; Perozzo, Remo; Tardy, Sébastien; ... Scapozza, Leonardo
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cellsMarsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
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Korszerű méretkizáráso kromatográfia: fehérje aggregátumok elválasztásaFekete, Szabolcs; Fekete, Jenö; Guillarme, Davy;
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Liquid chromatography and supercritical fluid chromatography as alternative techniques to gas chromatography for the rapid screening of anabolic agents in urineDesfontaine, Vincent; Nováková, Lucie; Ponzetto, Federico; Nicoli, Raul; ... Guillarme, Davy
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Longitudinal monitoring of endogenous steroids in human serum by UHPLC-MS/MS as a tool to detect testosterone abuse in sportsPonzetto, Federico; Mehl, Florence; Boccard, Julien; Baume, Norbert; ... Nicoli, Raul
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Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anestheticsIng Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
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