Département de chimie organique

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2022

Scientific Articles

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A mating mechanism to generate diversity for the Darwinian selection of DNA-encoded synthetic moleculesVummidi, Balayeshwanth R.; Farrera Soler, Lluc; Daguer, Jean Pierre; Dockerill, Millicent; ... Winssinger, Nicolas
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Acetylene Derivatives of Cationic Diazaoxatriangulenes and Diaza [4]Helicenes ‐ Access to Red Emitters and Planar Chiral Stereochemical TraitsOndrisek, Pavol; Elie, Margaux; Pupier, Marion; de Aguirre, Adiran; ... Lacour, Jérôme
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Biosupramolecular networks: Taking inspiration from nature to create powerful synthetic platformsWatson, Emma; Winssinger, Nicolas;
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Combining recombinase polymerase amplification and DNA-templated reaction for SARS-CoV-2 sensing with dual fluorescence and lateral flow assay outputFarrera Soler, Lluc; Gonse, Arthur; Kim, Kitae; Barluenga Badiola, Sofia; Winssinger, Nicolas
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Cyclic Thiosulfonates for Thiol-Mediated Uptake: Cascade Exchangers, Transporters, InhibitorsKato, Takehiro; Lim, Bumhee; Cheng, Yangyang; Pham, Anh Tuan; ... Matile, Stefan
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HydroFlipper membrane tension probes: imaging membrane hydration and mechanical compression simultaneously in living cellsGarcia, José; Lopez Andarias, Javier; Maillard, Jimmy Stéphane; Mercier, Vincent; ... Matile, Stefan
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Photocleavable Fluorescent Membrane Tension Probes: Fast Release with Spatiotemporal Control in Inner Leaflets of Plasma Membrane, Nuclear Envelope, and Secretory PathwayLopez Andarias, Javier; Eblighatian, Krikor Bared; Pasquer, Quentin Titouan Loïc; Assies, Léa; ... Matile, Stefan
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Planarizable Push‐Pull Probes with Sulfoximine‐Bridged Dithienothiophene AcceptorsGarcia, José; Lopez Andarias, Javier; Sakai, Naomi; Matile, Stefan;
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Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral EntryLim, Bumhee; Kato, Takehiro; Besnard, Céline; Poblador Bahamonde, Amalia Isabel; ... Matile, Stefan
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Stereoselective Access to Conjugated and Cross-Conjugated Dienoates by Rh- and Ru-Catalyzed Isomerizations of VinylcyclopropanesGarbo, Michele; Mazet, Clement;
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Straightforward Synthesis of Indenes by Gold-Catalyzed Intramolecular Hydroalkylation of YnamidesThilmany, Pierre; Guarnieri Ibanez, Alejandro José; Jacob, Clément; Lacour, Jérôme; Evano, Gwilherm
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Time‐Dependent Hydrogen Bond Network Formation in Glycerol‐Based Deep Eutectic SolventsDziubinska‐Kühn, Katarzyna; Pupier, Marion; Matysik, Jörg; Viger-Gravel, Jasmine; ... Kowalska, Magdalena
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Transition metal-catalyzed (remote) deconjugative isomerization of α,β-unsaturated carbonylsScaringi, Simone; Mazet, Clement;

Doctoral Thesis

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Dynamic Covalent Chemistry of Cyclic Oligochalcogenides and Phosphorothioates for Thiol-Mediated UptakeLaurent, Quentin François Antoine;
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Encoded chemical libraries: exploring dynamic and evolvable libraries leveraged on PNA-taggingFarrera Soler, Lluc;

2021

Scientific Articles

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Teflon Magnetic Stirring Capsules (TMSC) as a Practical and Reusable Delivery System for Sensitive Reagents and CatalystsTaillemaud, Sylvain; Rosset, Stéphane; Mazet, Clement;
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A minimal hybridization chain reaction (HCR) system using peptide nucleic acidsKim, Kitae; Angerani, Simona; Winssinger, Nicolas;
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Access to Highly Stereodefined 1,4-cis-Polydienes by a [Ni/Mg] Orthogonal Tandem Catalytic PolymerizationFiorito, Daniele; Simon, Malaury; Thomas, Christophe M.; Mazet, Clement;
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Bioinspired Ether Cyclizations within a π‐Basic Capsule Compared to Autocatalysis on π‐Acidic Surfaces and Pnictogen‐Bonding CatalystsHao, Xiaoyu; Li, Tian‐Ren; Chen, Hao; Gini, Andrea; ... Matile, Stefan
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Biosupramolecular Systems: Integrating Cues into ResponsesWatson, Emma; Angerani, Simona; Sabale, Pramod Madhavrao; Winssinger, Nicolas;
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Bright Long‐Lived Circularly Polarized Luminescence in Chiral Chromium(III) ComplexesJimenez, Juan; Poncet, Maxime Arnaud; Míguez‐Lago, Sandra; Grass, Stéphane; ... Piguet, Claude
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Chiral Near‐Infrared Fluorophores by Self‐Promoted Oxidative Coupling of Cationic Helicenes with Amines/EnaminesBosson, Johann; Labrador Beltran, Maria Géraldine; Besnard, Céline; Jacquemin, Denis; Lacour, Jérôme
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Combined spectroscopic studies on post-functionalized Au25 cluster as an ATR-FTIR sensor for cationsBaghdasaryan, Ani; Brun, Elodie; Wang, Yuming; Salassa, Giovanni; ... Buergi, Thomas
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Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiologyStangherlin, Alessandra; Watson, Joseph L.; Wong, David C. S.; Barbiero, Silvia; ... O'Neill, John S.
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Computational Study of Benzosultam Formation through Gold(I)‐Catalyzed Ammoniumation/Nucleophilic Substitution ReactionPertschi, Romain; de Aguirre, Adiran; Pale, Patrick; Blanc, Aurélien; Poblador Bahamonde, Amalia Isabel
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Diastereoselective Amplification of a Mechanically Chiral [2]CatenaneCaprice, Kenji; Pal, David; Besnard, Céline; Galmés, Bartomeu; ... Cougnon, Fabien
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Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissueMartinent, Rémi; Tawffik, Salman; Lopez Andarias, Javier; Moreau, Dimitri; ... Matile, Stefan
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Dual Bcl-XL /Bcl-2 inhibitors discovered from DNA-encoded libraries using a fragment pairing strategyDaguer, Jean Pierre; Gonse, Arthur; Shchukin, Yevhenii; Farrera Soler, Lluc; ... Winssinger, Nicolas
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Enabling Cyclization Strategies through Carbonyl-Ylide-Mediated Synthesis of Malonate Enol EthersVinas, Julia; Levitre, Guillaume; de Aguirre, Adiran; Besnard, Céline; ... Lacour, Jérôme
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Experimental Identification of Immuno- dominant B-cell Epitopes from SARS-CoV-2Farrera Soler, Lluc; Daguer, Jean Pierre; Barluenga Badiola, Sofia; Winssinger, Nicolas;
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Flipper Probes for the CommunityAssies, Léa; Garcia, José; Piazzolla, Francesca; Sanchez, Samantha; ... Matile, Stefan
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Fluorescent Membrane Tension Probes for Early EndosomesPiazzolla, Francesca; Mercier, Vincent; Assies, Léa; Sakai, Naomi; ... Matile, Stefan
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Genetically Encoded Supramolecular Targeting of Fluorescent Membrane Tension Probes within Live Cells: Precisely Localized Controlled Release by External Chemical StimulationLopez Andarias, Javier; Strakova, Karolina; Martinent, Rémi; Jimenez Rojo, Noemi; ... Matile, Stefan
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Growth Dynamics and Electron Reflectivity in Ultrathin Films of Chiral Heptahelicene on Metal (100) Surfaces Studied by Spin‐Polarized Low Energy Electron MicroscopyBaljozović, Miloš; Fernandes Cauduro, André L.; Seibel, Johannes; Mairena, Anaïs; ... Ernst, Karl-Heinz
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High Sensitivity Detection of a Solubility Limiting Surface Transformation of Drug Particles by DNP SENSViger-Gravel, Jasmine; Pinon, Arthur C.; Björgvinsdóttir, Snædís; Skantze, Urban; ... Emsley, Lyndon
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Hybrids of cationic [4]helicene and N-heterocyclic carbene as ligands for complexes exhibiting (chir)optical properties in the far red spectral windowTarrieu, Robert; Hernandez Delgado, Irène; Zinna, Francesco; Dorcet, Vincent; ... Lacour, Jérôme
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Identification of a Covalent Importin-5 Inhibitor, Goyazensolide, from a Collective Synthesis of FuranoheliangolidesLiu, Weilong; Patouret, Rémi; Barluenga Badiola, Sofia; Plank, Michaël; ... Winssinger, Nicolas
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Inhibition of Thiol‐Mediated Uptake with Irreversible Covalent InhibitorsLim, Bumhee; Cheng, Yangyang; Kato, Takehiro; Pham, Anh Tuan; ... Matile, Stefan
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Inhibitors of thiol-mediated uptakeCheng, Yangyang; Pham, Anh Tuan; Kato, Takehiro; Lim, Bumhee; ... Matile, Stefan
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Kinesin-1 activity recorded in living cells with a precipitating dyeAngerani, Simona; Lindberg, Eric; Klena, Nikolai; Bleck, Christopher K. E.; ... Winssinger, Nicolas
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Kinetically Controlled Stereoselective Access to Branched 1,3-Dienes by Ru-Catalyzed Remote Conjugative IsomerizationScaringi, Simone; Mazet, Clement;
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La formation des vésicules intraluminales de l'endosome est contrôlée par la tension membranaireMercier, Vincent; Larios, Jorge; Molinard, Guillaume; Goujon, Antoine; ... Gruenberg, Jean
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Lifetime Broadening and Impulsive Generation of Vibrational Coherence Triggered by Ultrafast Electron TransferAster, Alexander; Bornhof, Anna-Bea; Sakai, Naomi; Matile, Stefan; Vauthey, Eric
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Long-lived triplet charge-separated state in naphthalenediimide based donor–acceptor systemsAster, Alexander; Rumble, Christopher Allen; Bornhof, Anna-Bea; Huang, Hsin-Hua; ... Vauthey, Eric
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Luciferase Controlled Protein InteractionsChang, Dalu; Feng, Suihan; Girik, Vladimir; Riezman, Howard; Winssinger, Nicolas
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Mitochondrial membrane tension governs fissionMahecic, Dora; Carlini, Lina; Kleele, Tatjana; Colom Diego, Adai; ... Manley, Suliana
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Nickel-Catalyzed Kumada Vinylation of Enol Phosphates: A Comparative Mechanistic StudyPoisson, Philippe Alexandre; Tran, Gaël; Besnard, Céline; Mazet, Clement;
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Oligomers of Cyclic Oligochalcogenides for Enhanced Cellular UptakeMartinent, Rémi; Du, Dongchen; Lopez Andarias, Javier; Sakai, Naomi; Matile, Stefan
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Oligonucleotide Phosphorothioates Enter Cells by Thiol‐Mediated UptakeLaurent, Quentin François Antoine; Martinent, Rémi; Moreau, Dimitri; Winssinger, Nicolas; ... Matile, Stefan
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Organic Chemistry for First Year Medical Students: Addressing the 'Grand Public'Matile, Stefan;
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Passive coupling of membrane tension and cell volume during active response of cells to osmosisRoffay, Chloé; Molinard, Guillaume; Kim, Kyoohyun; Urbanska, Marta; ... Roux, Aurélien
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Photocatalysis in Chemical Biology: Extending the Scope of Optochemical Control and Towards New Frontiers in Semisynthetic Bioconjugates and BiocatalysisLiu, Weilong; Watson, Emma; Winssinger, Nicolas;
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Pnictogen-Bonding Catalysis and Transport Combined: Polyether Transporters Made In SituHumeniuk, Heorhii; Gini, Andrea; Hao, Xiaoyu; De Sousa Coelho, Filipe Diogo; ... Matile, Stefan
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Regiodivergent synthesis of pyrazino-indolines vs. triazocines via α-imino carbenes addition to imidazolidinesGuarnieri Ibanez, Alejandro José; de Aguirre, Adiran; Besnard, Céline; Poblador Bahamonde, Amalia Isabel; Lacour, Jérôme
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Regioselective Short Synthesis of Epiisoborneol Neopentyl Ether as Chiral Auxiliary: An Absolute Configuration ResetPiątek, Anna; Chapuis, Christian;
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Rh(II)-Catalyzed Condensations of N-Sulfonyl-1,2,3-triazoles with AminalsSaleh, Nidal; Lacour, Jérôme;
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Role of Intercluster and Interligand Dynamics of [Ag25(DMBT)18] Nanoclusters by Multinuclear Magnetic Resonance SpectroscopySalassa, Giovanni; Krishnadas, Kumaranchira Ramankutty; Pupier, Marion; Viger-Gravel, Jasmine; Buergi, Thomas
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SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1Pagano, Sabrina; Yerly Ferrillo, Sabine; Meyer, Benjamin; Juillard Mochon, Catherine; ... Vuilleumier, Nicolas
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Singlet Fission in a Flexible Bichromophore with Structural and Dynamic ControlAster, Alexander; Zinna, Francesco; Rumble, Christopher Allen; Lacour, Jérôme; Vauthey, Eric
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Spirocyclic Amide Acetal Synthesis by [CpRu]‐Catalyzed Condensations of α‐Diazo‐β‐Ketoesters with γ‐LactamsPertschi, Romain; Brun, Elodie; de Aguirre, Adiran; Guenee, Laure; ... Lacour, Jérôme
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Structural analysis of water in ionic liquid domains – A low pressure studyDziubinska-Kühn, Katarzyna; Croese, Jared; Pupier, Marion; Matysik, Jörg; ... Kowalska, Magdalena
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Suprastapled Peptides: Hybridization-Enhanced Peptide Ligation and Enforced α-Helical Conformation for Affinity Selection of Combinatorial LibrariesSabale, Pramod Madhavrao; Imiolek, Mateusz Lukasz; Raia, Pierre; Barluenga Badiola, Sofia; Winssinger, Nicolas
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Synthesis of α-exo-Methylene-γ-butyrolactones: Recent Developments and Applications in Natural Product SynthesisLiu, Weilong; Winssinger, Nicolas;
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The Nuclear Transport Protein Importin-5: A Promising Target in Oncology and VirologyPatouret, Rémi;
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The primary dipole of flipper probesGarcia, José; Lopez Andarias, Javier; Sakai, Naomi; Matile, Stefan;
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Thiol-Mediated UptakeLaurent, Quentin François Antoine; Martinent, Rémi; Lim, Bumhee; Pham, Anh Tuan; ... Matile, Stefan
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Total Syntheses of Paraconic Acids and 1,10-seco-Guaianolides via a Barbier Allylation/Translactonization Cascade of 3-(Bromomethyl)-2(5H)-furanoneLiu, Weilong; Yu, Zhimei; Winssinger, Nicolas;
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Transition metal-catalyzed alkene isomerization as an enabling technology in tandem, sequential and domino processesFiorito, Daniele; Scaringi, Simone; Mazet, Clement;
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Two-step immobilization of metronidazole prodrug on TEMPO cellulose nanofibrils through thiol-yne click chemistry for in situ controlled releaseDurand, Hippolyte; Baussanne, Isabelle; Demeunynck, Martine; Viger-Gravel, Jasmine; ... Bras, Julien

Book Chapters

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Anion Transport in Lipid Bilayer Membranes Using Halogen BondsVargas Jentzsch, Rodrigo Andreas; Matile, Stefan;

Présentations / Interventions

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SARS-COV2- infection as a trigger of humoral response against apolipoprotein A-1Pagano, Sabrina; Yery, Sabine; Meyer, Benjamin; Juillard Mochon, Catherine; ... Vuilleumier, Nicolas

Preprints

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Chiral control of spin-crossover dynamics in Fe(II) complexesOppermann, Malte; Zinna, Francesco; Lacour, Jérôme; Chergui, Majed;

Doctoral Thesis

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Anion-π Catalysis with Peptides and Synthesis of Thiol-Mediated Uptake InhibitorsPham, Anh Tuan;
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Cu- and Pd-catalyzed Selective Transformations of (poly)enesDesfeux, Camille Marie Odette;
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Oligomers of Cyclic Oligochalcogenides: New Privileged Scaffolds for the Delivery of Proteins and Quantum Dots in 2D and 3D Cell CulturesMartinent, Rémi;
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Supramolecular Systems Operating in Lipid Bilayer MembranesHumeniuk, Heorhii;
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Transition Metal-Catalyzed Stereoconvergent Reactions Utilizing Stereoisomeric Mixtures of VinylcyclopropanesGarbo, Michele;

2020

Scientific Articles

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A Catalytic Dual Isomerization/Allylboration Sequence for the Stereoselective Construction of Congested Secondary Homoallylic AlcoholsLiu, Yangbin; Mazet, Clement;
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Access to Chiral Rigid Hemicyanine Fluorophores from Tröger Bases and α-Imino CarbenesSaleh, Nidal; Bosmani, Alessandro; Besnard, Céline; Buergi, Thomas; ... Lacour, Jérôme
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Access to Optically Active 7-Membered Rings by a 2-Step Synthetic Sequence: Cu-Catalyzed Stereoselective Cyclopropanation of Branched 1,3-Dienes/Rh-Catalyzed Stereoconvergent [5 + 2] CycloadditionGarbo, Michele; Besnard, Céline; Guenee, Laure; Mazet, Clement;
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Automated high-content imaging for cellular uptake, from the Schmuck cation to the latest cyclic oligochalcogenidesMartinent, Rémi; Lopez Andarias, Javier; Moreau, Dimitri; Cheng, Yangyang; ... Matile, Stefan
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Caprin‐1 Promotes Cellular Uptake of Nucleic Acids with Backbone and Sequence DiscriminationGalli, Valentina; Sadhu, Kalyan Kumar; Masi, Daniela; Saarbach, Jacques; ... Winssinger, Nicolas
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Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane NetworksLopez Andarias, Javier; Saarbach, Jacques; Moreau, Dimitri; Cheng, Yangyang; ... Matile, Stefan
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Chemical Genetics of AGC-kinases Reveals Shared Targets of Ypk1, Protein Kinase A and Sch9Plank, Michaël; Perepelkina, Mariya; Muller, Markus Johann; Vaga, Stefania; ... Loewith, Robbie Joséph
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Chiroptical detection of a model ruthenium dye in water by circularly polarized-electrochemiluminescenceVoci, Silvia; Zinna, Francesco; Arrico, Lorenzo; Grass, Stéphane; ... Sojic, Neso
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Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory PathwayJimenez Rojo, Noemi; Leonetti, Manuel D.; Zoni, Valeria; Colom Diego, Adai; ... Riezman, Howard
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Direct Access to Chiral Secondary Amides by Copper-Catalyzed Borylative Carboxamidation of Vinylarenes with IsocyanatesFiorito, Daniele; Liu, Yangbin; Besnard, Céline; Mazet, Clement;
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EditorialKundig, Ernst Peter;
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Empowering Global Chemical Biology at the Dawn of the New DecadeHoogendoorn, Sascha; Aye, Yimon;
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Enantiopure encaged Verkade's superbases: Synthesis, chiroptical properties, and use as chiral derivatizing agentYang, Jian; Chatelet, Bastien; Hérault, Damien; Dufaud, Véronique; ... Martinez, Alexandre
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Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formationMercier, Vincent; Larios, Jorge; Molinard, Guillaume; Goujon, Antoine; ... Roux, Aurélien
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Enhanced SNP-sensing using DNA-templated reactions through confined hybridization of minimal substrates (CHOMS)Kim, Kitae; Winssinger, Nicolas;
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Everything you wanted to know about phase and reference frequency in one- and two-dimensional NMR spectroscopySheberstov, Kirill; Sistare Guardiola, Eduard; Jeannerat, Damien;
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Fluorescent Membrane Tension Probes for Super-Resolution Microscopy: Combining Mechanosensitive Cascade Switching with Dynamic-Covalent Ketone ChemistryGarcia, José; Maillard, Jimmy Stéphane; Fureraj, Ina; Strakova, Karolina; ... Matile, Stefan
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Fluorescent small-molecule agonists as follicle-stimulating hormone receptor imaging toolsHoogendoorn, Sascha; van Puijvelde, Gijs H. M.; van der Marel, Gijs A.; van Koppen, Chris J.; ... Overkleeft, Herman S.
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From Phenotypic Hit to Chemical Probe: Chemical Biology Approaches to Elucidate Small Molecule Action in Complex Biological SystemsPasquer, Quentin; Tsakoumagkos, Ioannis; Hoogendoorn, Sascha;
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From reactive carbenes to chiral polyether macrocycles in two steps – synthesis and applications made easy?Homberg, Alexandre; Lacour, Jérôme;
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HaloFlippers: a General Tool for the Fluorescence Imaging of Precisely Localized Membrane Tension Changes in Living CellsStrakova, Karolina; Lopez Andarias, Javier; Jimenez Rojo, Noemi; Chambers, Joseph E.; ... Matile, Stefan
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High-speed atomic force microscopy highlights new molecular mechanism of daptomycin actionZuttion, Francesca; Colom Diego, Adai; Matile, Stefan; Farago, Denes; ... Casuso, Ignacio
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Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasmaFarrera Soler, Lluc; Daguer, Jean Pierre; Barluenga Badiola, Sofia; Vadas, Oscar; ... Winssinger, Nicolas
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