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On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm Conod, Arwen; Silvano, Marianna; Ruiz Altaba, Ariel 2022
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Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1 Bernal Zamora, Carolina; Silvano, Marianna; Tapponnier, Yann; Anand, Santosh; ... Ruiz Altaba, Ariel 2020
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Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer Nowak-Sliwinska, Patrycja; Scapozza, Leonardo; Ruiz Altaba, Ariel 2019
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Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner Kuciak, Monika; Mas, Christophe; Borges Grazina, Ana Isabel; Sánchez-Gómez, Pilar; Ruiz Altaba, Ariel 2019
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The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases Mishra, Sonakshi; Bernal Zamora, Carolina; Silvano, Marianna; Anand, Santosh; Ruiz Altaba, Ariel 2019
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Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells Seth, Chandan; Mas, Christophe; Conod, Arwen; Mueller, Jens; ... Ruiz Altaba, Ariel 2016
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In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases Singovski, Grigori; Bernal Zamora, Carolina; Kuciak, Monika; Siegl-Cachedenier, Irène; ... Ruiz Altaba, Ariel 2016
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Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling Seth, Chandan; Ruiz Altaba, Ariel 2016
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A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12 Duquet, Arnaud; Melotti, Alice; Mishra, Sonakshi; Malerba, Monica; ... Ruiz Altaba, Ariel 2014
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Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy Aberger, Fritz; Ruiz Altaba, Ariel 2014
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The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer Melotti, Alice; Mas, Christophe; Kuciak, Monika; Lorente Trigos, Aiala; ... Ruiz Altaba, Ariel 2014
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Morphogenetic action through flux-limited spreading Verbeni, M; Sánchez, O; Mollica, E; Siegl-Cachedenier, Irène; ... Soler, J 2013
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On flux-limited morphogenesis Verbeni, M.; Sánchez, O.; Mollica, E.; Siegl-Cachedenier, Irène; ... Soler, J. 2013
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Hedgehog signaling and the Gli code in stem cells, cancer, and metastases Ruiz Altaba, Ariel 2011
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BMP signaling promotes the growth of primary human colon carcinomas in vivo Lorente-Trigos, Aiala; Varnat, Frédéric; Melotti, Alice; Ruiz Altaba, Ariel 2010
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Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals Stecca, Barbara; Ruiz Altaba, Ariel 2010
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NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53 Zbinden, Marie; Duquet, Arnaud; Lorente-Trigos, Aiala; Ngwabyt, Sandra-Nadia; ... Ruiz Altaba, Ariel 2010
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Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations Mas, Christophe; Ruiz Altaba, Ariel 2010
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Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas Varnat, Frédéric; Siegl-Cachedenier, Irène; Malerba, Monica; Gervaz, Pascal; Ruiz Altaba, Ariel 2010
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Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling Varnat, Frédéric; Zacchetti, Giovanna; Ruiz Altaba, Ariel 2010
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