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Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases Maedler, Kathrin; Schulthess, Fabienne T.; Bielman, Christelle; Berney, Thierry; ... Roduit, Raphael 2008
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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 Brun, Thierry; He, Kai Hui Hu; Lupi, Roberto; Boehm, Bernhard; ... Gauthier, Benoît 2008
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The Fas pathway is involved in pancreatic beta cell secretory function Schumann, D. M.; Maedler, Kathrin; Franklin, Isobel; Konrad, Daniel; ... Donath, M. Y. 2007
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Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 Maedler, Kathrin; Schumann, Desiree; Schulthess, Fabienne; Oberholzer, José; ... Donath, Marc Y 2006
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Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets Maedler, Kathrin; Schumann, Desiree M; Sauter, Nadine; Ellingsgaard, Helga; ... Donath, Marc Y 2006
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Sulfonylurea induced beta-cell apoptosis in cultured human islets Maedler, Kathrin; Carr, Richard D; Bosco, Domenico; Zuellig, Richard A; ... Donath, Marc Y 2005
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Extracellular matrix protects pancreatic beta-cells against apoptosis: role of short- and long-term signaling pathways Hammar Bouveret, Eva; Parnaud, Géraldine; Bosco, Domenico; Perriraz-Mayer, Nadja; ... Halban, Philippe A. 2004
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Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets Maedler, Kathrin; Sergeev, Pavel; Ehses, J. A.; Mathe, Zoltan; ... Donath, M. Y. 2004
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Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function Maedler, Kathrin; Oberholzer, José; Bucher, Pascal Alain Robert; Spinas, Giatgen A; Donath, Marc 2003
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FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replication Maedler, Kathrin; Fontana, Adriano; Ris, Frédéric; Sergeev, Pavel; ... Donath, M.Y 2002
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Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets Maedler, Kathrin; Sergeev, Pavel; Ris, Frédéric; Oberholzer, José; ... Donath, M. Y. 2002