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Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase Luczkowska, Karolina; Stekelenburg, Caroline; Sloan Bena, Frédérique; Ranza, Emmanuelle Nathalie; ... Maechler, Pierre 2020
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Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling Oberhauser, Lucie; Granziera, Sabrina; Colom Diego, Adai; Goujon, Antoine; ... Maechler, Pierre 2020
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AMPK profiling in rodent and human pancreatic beta-cells under nutrient-rich metabolic stress Brun, Thierry; Jimenez-Sanchez, Cécilia; Madsen, Jesper Grud Skat; Hadadi, Noushin; ... Maechler, Pierre 2020
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AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics Voss, Caroline M; Andersen, Jens V; Jakobsen, Emil; Siamka, Olga; ... Waagepetersen, Helle S 2020
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L’exposition des cellules bêta au fructose potentialise la sécrétion d’insuline via une signalisation par l’ATP Brun, Thierry; Bartley, Clarissa; Maechler, Pierre 2019
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Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis Martin-Levilain, Juliette; Li, Lingzi; Maechler, Pierre 2019
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In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way Li, Lingzi; Martin-Levilain, Juliette; Jimenez-Sanchez, Cécilia; Karaca Emre, Melis; ... Maechler, Pierre 2019
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Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction Lander, Sharon S; Khan, Usman; Lewandowski, Nicole; Chakraborty, Darpan; ... Gaisler-Salomon, Inna 2019
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Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion Casimir, Marina Shamini; Chaffard, Gaelle; Maechler, Pierre 2019
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Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling Bartley, Clarissa; Brun, Thierry; Oberhauser, Lucie; Grimaldi, Mariagrazia; ... Maechler, Pierre 2019
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Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset Li, Lingzi; Krznar, Petra; Erban, Alexander; Agazzi, Andréa; ... Maechler, Pierre 2019
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Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis Karaca Emre, Melis; Martin-Levilain, Juliette; Grimaldi, Mariagrazia; Li, Lingzi; ... Maechler, Pierre 2018
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Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation Hohnholt, Michaela C; Andersen, Vibe H; Andersen, Jens V; Christensen, Sofie K; ... Waagepetersen, Helle S 2018
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Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity Li, Ning; Karaca Emre, Melis; Maechler, Pierre 2017
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Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression Brun, Julia; Berthou, Flavien; Trajkovski, Mirko; Maechler, Pierre; ... Bonnet, Nicolas 2017
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Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; ... Donath, Marc Y 2017
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Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions Kaczmarek, P; Skrzypski, M; Pruszynska-Oszmalek, E; Sassek, M; ... Strowski, M Z 2017
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Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia Grimaldi, Mariagrazia; Karaca Emre, Melis; Latini, Livia; Brioudes, Estelle; ... Maechler, Pierre 2017
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Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; ... Maechler, Pierre 2017
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Glutamate pathways of the beta-cell and the control of insulin secretion Maechler, Pierre 2017
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