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Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells Oberhauser, Lucie; Jiménez-Sánchez, Cecilia; Madsen, Jesper Grud Skat; Duhamel, Dominique; ... Maechler, Pierre 2022
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Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity Stekelenburg, Caroline; Blouin, Jean-Louis; Santoni, Federico; Zaghloul, Norann; ... Schwitzgebel Luscher, Valérie 2022
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Circulating 1,5-anhydroglucitol as a biomarker of ß-cell mass independent of a diabetes phenotype in human subjects Jiménez-Sánchez, Cecilia; Mezza, Teresa; Sinturel, Flore; Li, Lingzi; ... Maechler, Pierre 2022
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Glutamate dehydrogenase is important for ammonia fixation and amino acid homeostasis in brain during hyperammonemia Voss, Caroline M.; Arildsen, Lene; Nissen, Jakob D.; Waagepetersen, Helle S.; ... Walls, Anne B. 2021
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Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα Stojanovic, Ozren; Altirriba, Jordi; Rigo, Dorothée; Spiljar, Martina; ... Trajkovski, Mirko 2021
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Lipid-induced adaptations of the pancreatic beta-cell to glucotoxic conditions sustain insulin secretion Oberhauser, Lucie; Maechler, Pierre 2021
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Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation Merlin, Johanna; Ivanov, Stoyan; Dumont, Adélie; Sergushichev, Alexey; ... Yvan-Charvet, Laurent 2021
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AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics Voss, Caroline M; Andersen, Jens V; Jakobsen, Emil; Siamka, Olga; ... Waagepetersen, Helle S 2020
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Macrophage-derived glutamine boosts satellite cells and muscle regeneration Shang, Min; Cappellesso, Federica; Amorim, Ricardo; Serneels, Jens; ... Mazzone, Massimiliano 2020
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Mitochondrial carriers regulating insulin secretion profiled in human islets upon metabolic stress Jiménez-Sánchez, Cecilia; Brun, Thierry; Maechler, Pierre 2020
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AMPK profiling in rodent and human pancreatic beta-cells under nutrient-rich metabolic stress Brun, Thierry; Jimenez-Sanchez, Cécilia; Madsen, Jesper Grud Skat; Hadadi, Noushin; ... Maechler, Pierre 2020
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Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling Oberhauser, Lucie; Granziera, Sabrina; Colom Diego, Adai; Goujon, Antoine; ... Maechler, Pierre 2020
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Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase Luczkowska, Karolina; Stekelenburg, Caroline; Sloan Bena, Frédérique; Ranza, Emmanuelle Nathalie; ... Maechler, Pierre 2020
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Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction Lander, Sharon S; Khan, Usman; Lewandowski, Nicole; Chakraborty, Darpan; ... Gaisler-Salomon, Inna 2019
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Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion Casimir, Marina Shamini; Chaffard, Gaelle; Maechler, Pierre 2019
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Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis Martin-Levilain, Juliette; Li, Lingzi; Maechler, Pierre 2019
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Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset Li, Lingzi; Krznar, Petra; Erban, Alexander; Agazzi, Andréa; ... Maechler, Pierre 2019
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In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way Li, Lingzi; Martin-Levilain, Juliette; Jimenez-Sanchez, Cécilia; Karaca Emre, Melis; ... Maechler, Pierre 2019
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L'exposition des cellules bêta au fructose potentialise la sécrétion d'insuline via une signalisation par l'ATP Brun, Thierry; Bartley, Clarissa; Maechler, Pierre 2019
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Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling Bartley, Clarissa; Brun, Thierry; Oberhauser, Lucie; Grimaldi, Mariagrazia; ... Maechler, Pierre 2019
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