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 TitleAuthors / EditorsDate
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L’exposition des cellules bêta au fructose potentialise la sécrétion d’insuline via une signalisation par l’ATP Brun, Thierry; Bartley, Clarissa; Maechler, Pierre 2019
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Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling Bartley, Clarissa; Brun, Thierry; Oberhauser, Lucie; Grimaldi, Mariagrazia; ... Maechler, Pierre 2019
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Beta-cell mitochondrial carriers and the diabetogenic stress response Brun, Thierry; Maechler, Pierre 2016
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Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets Brun, Thierry; Li, Ning; Jourdain, Alexis; Gaudet, Pascale; ... Maechler, Pierre 2015
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Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids Brun, Thierry; Scarcia, Pasquale; Li, Ning; Gaudet, Pascale; ... Maechler, Pierre 2013
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Mitochondrial dysfunction in pancreatic β cells Supale, Sachin; Li, Ning; Brun, Thierry; Maechler, Pierre 2012
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NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Li, Ning; Li, Bin; Brun, Thierry; Deffert-Delbouille, Christine; ... Maechler, Pierre 2012
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In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice Hu He, Kai Hui; Lorenzo, Petra I; Brun, Thierry; Jimenez Moreno, Carmen M; ... Gauthier, Benoît 2011
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Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism Vetterli, Laurene Marine; Brun, Thierry; Giovannoni, Laurianne; Bosco, Domenico; Maechler, Pierre 2011
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Role of mitochondria in beta-cell function and dysfunction Maechler, Pierre; Li, Ning; Casimir, Marina Shamini; Vetterli, Laurene Marine; ... Brun, Thierry 2010
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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism Frigerio, Francesca; Brun, Thierry; Bartley, C.; Usardi, A.; ... Maechler, Pierre 2010
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Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction Li, Ning; Brun, Thierry; Cnop, Miriam; Cunha, Daniel A.; ... Maechler, Pierre 2009
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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 Brun, Thierry; He, Kai Hui Hu; Lupi, Roberto; Boehm, Bernhard; ... Gauthier, Benoît 2008
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A focus on the role of Pax4 in mature pancreatic islet beta-cell expansion and survival in health and disease Brun, Thierry; Gauthier, Benoît 2008
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The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells Brun, Thierry; Duhamel, Dominique; Hu He, Kaihui; Wollheim, Claes; Gauthier, Benoît 2007
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The zinc finger-containing transcription factor Gata-4 is expressed in the developing endocrine pancreas and activates glucagon gene expression Ritz-Laser, Beate; Mamin, Aline; Brun, Thierry; Avril, Isabelle; ... Philippe, Jacques 2005
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The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets Brun, Thierry; Franklin, Isobel; St-Onge, Luc; Biason-Lauber, Anna; ... Gauthier, Benoît 2004
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Agenesis of human pancreas due to decreased half-life of insulin promoter factor 1 Schwitzgebel Luscher, Valérie; Mamin, Aline; Brun, Thierry; Ritz, Beate Andréa; ... Philippe, Jacques 2003
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Regulation of acetyl-CoA carboxylase gene expression by nutrients in the pancreatic β-cell Brun, Thierry 1994