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Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism Roomp, Kirsten; Kristinsson, Hjalti; Schvartz, Domitille; Ubhayasekera, Kumari; ... Bergsten, Peter 2017
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Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets Pongratz, Rebecca L.; Kibbey, Richard G.; Kirkpatrick, Clare; Zhao, Xiaojian; ... Cline, Gary W. 2009
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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 Brun, Thierry; He, Kai Hui Hu; Lupi, Roberto; Boehm, Bernhard; ... Gauthier, Benoît 2008
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Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex Thurmond, D. C.; Gonelle-Gispert, Carmen; Furukawa, Megumi; Halban, Philippe A.; Pessin, J. E. 2003
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Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion Wang, Haiyan; Maechler, Pierre; Antinozzi, Peter; Hagenfeldt-Johansson, Kerstin Arlette; Wollheim, Claes 2000
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Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells Maechler, Pierre; Jornot, L; Wollheim, Claes 1999
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Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists Wollheim, Claes; Biden, Trevor John 1986