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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets Hall, Elin; Dayeh, Tasnim; Kirkpatrick, Clare; Wollheim, Claes; ... Ling, Charlotte 2013
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release Spégel, Peter; Sharoyko, Vladimir V; Goehring, Isabel; Danielsson, Anders P H; ... Mulder, Hindrik 2013
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Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction Bugliani, Marco; Liechti, Robin; Cheon, Hwanju; Suleiman, Mara; ... Marchetti, Piero 2013
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress Schvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles 2012
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Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells Park, Kyu-Sang; Wiederkehr, Andreas; Wollheim, Claes 2012
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Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells Epstein, Sharon; Kirkpatrick, Clare; Castillon, Guillaume Alain; Muniz, Manuel; ... Riezman, Howard 2012
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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes Mahdi, Taman; Hänzelmann, Sonja; Salehi, Albert; Muhammed, Sarheed J; ... Rosengren, Anders H 2012
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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets Marchetti, P; Lupi, R; Bugliani, Marco; Kirkpatrick, Clare; ... Dotta, F 2012
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Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells Akhmedov, Dmitry; De Marchi, Umberto; Wollheim, Claes; Wiederkehr, Andreas 2012
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Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box Perakakis, Nikolaos; Danassi, Despoina; Alt, Marcus; Tsaroucha, Eleni; ... Päth, Günter 2012
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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes Yang, Beatrice T; Dayeh, Tasnim A; Volkov, Petr A; Kirkpatrick, Clare; ... Ling, Charlotte 2012
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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets Taneera, Jalal; Lang, Stefan; Sharma, Amitabh; Fadista, Joao; ... Groop, Leif 2012
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Mitochondrial signals drive insulin secretion in the pancreatic β-cell Wiederkehr, Andreas; Wollheim, Claes 2012
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Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo Uhles, S; Wang, Haiyan; Bénardeau, A; Prummer, M; ... Sebokova, E 2011
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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress Kirkpatrick, Clare; Wiederkehr, Andreas; Baquie, Mathurin; Akhmedov, Dmitry; ... Wollheim, Claes 2011
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Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation Bonner, Caroline; Farrelly, Angela M; Concannon, Caoimhín G; Dussmann, Heiko; ... Prehn, Jochen H M 2011
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Mitochondrial matrix calcium is an activating signal for hormone secretion Wiederkehr, Andreas; Szanda, Gergo; Akhmedov, Dmitry; Mataki, Chikage; ... Wollheim, Claes 2011
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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets Yang, B T; Dayeh, T A; Kirkpatrick, Clare; Taneera, J; ... Ling, C 2011
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Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells Feldmann, Nicole; del Rio, Rafael Martin; Gjinovci, Asllan; Tamarit-Rodriguez, Jorge; ... Wiederkehr, Andreas 2011
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Imeglimin - A New Oral Anti-Diabetic that Targets the Three Key Defects of type 2 Diabetes Fouqueray, Pascale; Leverve, Xavier; Fontaine, Eric; Baquie, Mathurin; ... Bozec, Sophie 2011
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