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 TitleAuthors / EditorsDate
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Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells Zhang, Enming; Mohammed Al-Amily, Israa; Mohammed, Sarheed; Luan, Cheng; ... Salehi, Albert 2019
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Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase Andersson, Lotta E.; Shcherbina, Liliya; Al-Majdoub, Mahmoud; Vishnu, Neelanjan; ... Spégel, Peter 2018
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Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production Tubbs, Emily; Axelsson, Annika S; Vial, Guillaume; Wollheim, Claes; ... Rosengren, Anders H 2018
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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes Bugliani, Marco; Wollheim, Claes; Meda, Paolo 2018
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Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes Shcherbina, L.; Edlund, A.; Esguerra, J.L.S.; Abels, M.; ... Wierup, N. 2017
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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes Axelsson, Annika S; Tubbs, Emily; Mecham, Brig; Chacko, Shaji; ... Rosengren, Anders H 2017
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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell Ofori, Jones K.; Salunkhe, Vishal A.; Bagge, Annika; Vishnu, Neelanjan; ... Esguerra, Jonathan L. S. 2017
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes Ly, Luong Dai; Xu, Shanhua; Choi, Seong-Kyung; Ha, Chae-Myeong; ... Park, Kyu-Sang 2017
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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes Axelsson, A. S.; Mahdi, T.; Nenonen, H. A.; Singh, T.; ... Rosengren, A. H. 2017
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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes Prasad, Rashmi B; Lessmark, Anna; Almgren, Peter; Kovacs, Györgyi; ... Groop, Leif 2016
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Microbial signals to the brain control weight Trajkovski, Mirko; Wollheim, Claes 2016
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Intracellular alkalinization by phosphate uptake via type III sodium-phosphate cotransporter participates in high phosphate-induced mitochondrial oxidative stress and defective insulin secretion Nguyen, Tuyet Thi; Quan, Xianglan; Xu, Shanhua; Das, Ranjan; ... Park, Kyu-Sang 2016
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Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia Taneera, J.; Fadista, J.; Ahlqvist, E; Atac, D.; ... Groop, L. 2015
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Inhibition of the malate–aspartate shuttle in mouse pancreatic islets abolishes glucagon secretion without affecting insulin secretion Stamenkovic, Jelena A.; Andersson, Lotta E.; Adriaenssens, Alice E.; Bagge, Annika; ... Spégel, Peter 2015
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Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs? Wollheim, Claes; Maechler, Pierre 2015
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Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells Nguyen, Tuyet Thi; Quan, Xianglan; Hwang, Kyu-Hee; Xu, Shanhua; ... Park, Kyu-Sang 2015
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Essential Role of Mitochondrial Ca2+ Uniporter in the Generation of Mitochondrial pH Gradient and Metabolism-Secretion Coupling in Insulin-releasing Cells Quan, Xianglan; Nguyen, Tuyet Thi; Choi, Seong-Kyung; Xu, Shanhua; ... Park, Kyu-Sang 2015
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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion Dayeh, Tasnim; Volkov, Petr; Salö, Sofia; Hall, Elin; ... Ling, Charlotte 2014
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism Fadista, João; Vikman, Petter; Laakso, Emilia Ottosson; Mollet, Inês Guerra; ... Groop, Leif 2014
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TCF7L2 is a master regulator of insulin production and processing Zhou, Yuedan; Park, Soo-Young; Su, Jing; Bailey, Kathleen; ... Hansson, Ola 2014
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Mitochondrial phosphate transport during nutrient stimulation of INS-1E insulinoma cells Quan, Xianglan; Das, Ranjan; Xu, Shanhua; Cline, Gary W; ... Park, Kyu-Sang 2013
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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets Hall, Elin; Dayeh, Tasnim; Kirkpatrick, Clare; Wollheim, Claes; ... Ling, Charlotte 2013
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release Spégel, Peter; Sharoyko, Vladimir V; Goehring, Isabel; Danielsson, Anders P H; ... Mulder, Hindrik 2013
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Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction Bugliani, Marco; Liechti, Robin; Cheon, Hwanju; Suleiman, Mara; ... Marchetti, Piero 2013
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress Schvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles 2012
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Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells Epstein, Sharon; Kirkpatrick, Clare; Castillon, Guillaume Alain; Muniz, Manuel; ... Riezman, Howard 2012
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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes Mahdi, Taman; Hänzelmann, Sonja; Salehi, Albert; Muhammed, Sarheed J; ... Rosengren, Anders H 2012
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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets Marchetti, P; Lupi, R; Bugliani, Marco; Kirkpatrick, Clare; ... Dotta, F 2012
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Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells Akhmedov, Dmitry; De Marchi, Umberto; Wollheim, Claes; Wiederkehr, Andreas 2012
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Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC box Perakakis, Nikolaos; Danassi, Despoina; Alt, Marcus; Tsaroucha, Eleni; ... Päth, Günter 2012
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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes Yang, Beatrice T; Dayeh, Tasnim A; Volkov, Petr A; Kirkpatrick, Clare; ... Ling, Charlotte 2012
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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets Taneera, Jalal; Lang, Stefan; Sharma, Amitabh; Fadista, Joao; ... Groop, Leif 2012
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Mitochondrial signals drive insulin secretion in the pancreatic β-cell Wiederkehr, Andreas; Wollheim, Claes 2012
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Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting Cells Park, Kyu-Sang; Wiederkehr, Andreas; Wollheim, Claes 2012
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Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo Uhles, S; Wang, Haiyan; Bénardeau, A; Prummer, M; ... Sebokova, E 2011
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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stress Kirkpatrick, Clare; Wiederkehr, Andreas; Baquie, Mathurin; Akhmedov, Dmitry; ... Wollheim, Claes 2011
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Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutation Bonner, Caroline; Farrelly, Angela M; Concannon, Caoimhín G; Dussmann, Heiko; ... Prehn, Jochen H M 2011
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Mitochondrial matrix calcium is an activating signal for hormone secretion Wiederkehr, Andreas; Szanda, Gergo; Akhmedov, Dmitry; Mataki, Chikage; ... Wollheim, Claes 2011
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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets Yang, B T; Dayeh, T A; Kirkpatrick, Clare; Taneera, J; ... Ling, C 2011
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Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells Feldmann, Nicole; del Rio, Rafael Martin; Gjinovci, Asllan; Tamarit-Rodriguez, Jorge; ... Wiederkehr, Andreas 2011
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Imeglimin - A New Oral Anti-Diabetic that Targets the Three Key Defects of type 2 Diabetes Fouqueray, Pascale; Leverve, Xavier; Fontaine, Eric; Baquie, Mathurin; ... Bozec, Sophie 2011
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Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cells Coute, Yohann; Brunner, Yannick; Schvartz, Domitille; Hernandez, Celine; ... Sanchez, Jean-Charles 2010
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Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation Wallin, Tina; Ma, Zuheng; Ogata, Hirotaka; Jørgensen, Ingrid Hals; ... Björklund, Anneli 2010
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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells Akhmedov, Dmitry; Braun, Matthias; Mataki, Chikage; Park, Kyu-Sang; ... Wiederkehr, Andreas 2010
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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells Bonner, Caroline; Bacon, Siobhán; Concannon, Caoimhín G; Rizvi, Syed R; ... Prehn, Jochen H M 2010
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AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF. Kilbride, Seán M; Farrelly, Angela M; Bonner, Caroline; Ward, Manus W; ... Prehn, Jochen H M 2010
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Evidence against a direct role of klotho in insulin resistance Lorenzi, Olivier; Veyrat-Durebex, Christelle; Wollheim, Claes; Villemin, Pascal; ... Vischer, Ulrich Max 2010
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Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors Kirkpatrick, Clare; Marchetti, Piero; Purrello, Francesco; Piro, Salvatore; ... Wollheim, Claes 2010
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Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation Wiederkehr, Andreas; Park, Kyu-Sang; Dupont, Olivier; Demaurex, Nicolas; ... Wollheim, Claes 2009
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Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells Park, Kyu-Sang; Poburko, Damon; Wollheim, Claes; Demaurex, Nicolas 2009
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