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Bioactive Natural Products Prioritization Using Massive Multi-informational Molecular Networks Olivon, Florent; Allard, Pierre-Marie; Koval, Alexey; Righi, Davide; ... Litaudon, Marc 2017
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TORC2 Structure and Function Gaubitz, Christl; Prouteau, Manoel; Kusmider, Beata; Loewith, Robbie Joséph 2016
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Conjugation of N-acylhydrazone and 1,2,4-oxadiazole leads to the identification of active antimalarial agents Dos Santos Filho, José Maurício; de Queiroz E Silva, Diogo Manoel Alves; Macedo, Taís Soares; Teixeira, Helena Mariana Pitangueira; ... Soares, Milena Botelho Pereira 2016
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Cell-based multi-substrate assay coupled to UHPLC-ESI-MS/MS for a quick identification of class-specific HDAC inhibitors Zwick, Vincent; Simoes Avello, Claudia; Cuendet, Muriel 2016
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Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity Cincinelli, Raffaella; Zwick, Vincent; Musso, Loana; Zuco, Valentina; ... Dallavalle, Sabrina 2016
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Cross metathesis with hydroxamate and benzamide BOC-protected alkenes to access HDAC inhibitors and their biological evaluation highlighted intrinsic activity of BOC-protected dihydroxamates Zwick, Vincent; Nurisso, Alessandra; Simoes Avello, Claudia; Bouchet, Samuel; ... Bertrand, Philippe 2016
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Investigation on the ZBG-functionality of phenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase inhibitors Musso, Loana; Cincinelli, Raffaella; Zuco, Valentina; Zunino, Franco; ... Dallavalle, Sabrina 2015
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δ-Conotoxins synthesized using an acid-cleavable solubility tag approach reveal key structural determinants for NaV subtype selectivity Peigneur, Steve; Paolini-Bertrand, Marianne; Gaertner, Hubert François; Biass, Daniel; ... Hartley, Oliver 2014
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Combining topology and sequence design for the discovery of potent antimicrobial peptide dendrimers against multidrug-resistant Pseudomonas aeruginosa Stach, Michaela; Siriwardena, Thissa N; Kohler, Thilo; Van Delden, Christian; ... Reymond, Jean-Louis 2014
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Neutrophil migration towards C5a and CXCL8 is prevented by non-steroidal anti-inflammatory drugs via inhibition of different pathways Bertolotto, Maria; Contini, Paola; Ottonello, Luciano; Pende, Aldo; ... Montecucco, Fabrizio 2014
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Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers Dubost, Emmanuelle; Dumas, Noe; Fossey, Christine; Magnelli, Rosa; ... Fabis, Frederic 2012
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A short amino-terminal part of Arabidopsis phytochrome A induces constitutive photomorphogenic response Viczián, András; Ádám, Éva; Wolf, Iris; Bindics, János; ... Nagy, Ferenc 2012
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Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells Račková, Lucia; Cumaoğlu, Ahmet; Bağrıacık, E Umit; Štefek, Milan; ... Karasu, Çimen 2011
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Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor Mata, Miguel A; Satterly, Neal; Versteeg, Gijs A; Frantz, Doug; ... Fontoura, Beatriz M A 2011
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Sequence-structure-function relations of the mosquito leucine-rich repeat immune proteins Waterhouse, Robert; Povelones, Michael; Christophides, George K. 2010
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A large-scale protein-function database Apweiler, Rolf; Armstrong, Richard; Bairoch, Amos Marc; Cornish-Bowden, Athel; ... Tipton, Keith 2010
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Antioxidant profiles of new chemical entities as multifunctional hits for the treatment of neurodegenerative disorders Cressend, Delphine 2010
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Inherited dysfibrinogenemia: clinical phenotypes associated with five different fibrinogen structure defects Miesbach, Wolfgang; Scharrer, Inge; Henschen, Agnes; Neerman Arbez, Marguerite; ... Galanakis, Dennis 2010
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Siderophores as drug delivery agents: application of the "Trojan Horse" strategy Möllmann, Ute; Heinisch, Lothar; Bauernfeind, Adolf; Kohler, Thilo; Ankel-Fuchs, Dorothe 2009
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Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions Baudino, Lucie Clementine; Shinohara, Yasuro; Nimmerjahn, Falk; Furukawa, Jun-ichi; ... Izui, Shozo 2008
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Extraction of amino acids by reverse iontophoresis: simulation of therapeutic monitoring in vitro Sieg, Anke; Jeanneret, Fabienne; Fathi, Marc; Hochstrasser, Denis; ... Delgado-Charro, Begoña M. 2008
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Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship Boumendjel, Ahcène; Boccard, Julien; Carrupt, Pierre-Alain; Nicolle, Edwige; ... Dumontet, Charles 2008
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Highly potent HIV inhibition: engineering a key anti-HIV structure from PSC-RANTES into MIP-1 beta/CCL4 Gaertner, Hubert François; Lebeau, Olivier; Borlat, Irène; Cerini, Fabrice; ... Hartley, Oliver 2008
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Immediate-early gene regulation by interplay between different post-translational modifications on human histone H3 Kaleem, Afshan; Hoessli, Daniel; Ahmad, Ishtiaq; Walker-Nasir, Evelyne; ... Nasir-ud-Din, 2008
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Two independent routes of de novo vitamin B6 biosynthesis: not that different after all Fitzpatrick, Thérésa Bridget; Amrhein, Nikolaus; Kappes, Barbara; Macheroux, Peter; ... Raschle, Thomas 2007
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NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties Chegaev, K.; Lazzarato, L.; Tosco, P.; Cena, C.; ... Gasco, Alberto 2007
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Structure-permeation relationships for the non-invasive transdermal delivery of cationic peptides by iontophoresis Schuetz, Yannic; Carrupt, Pierre-Alain; Naik, Aarti; Guy, Richard H.; Kalia, Yogeshvar 2006
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The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity Fritzsche, Juliane; Alban, Susanne; Ludwig, Ralf J.; Rubant, Simone A.; ... Bendas, Gerd 2006
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Structural requirements of heparin and related molecules to exert a multitude of anti-inflammatory activities Ludwig, Ralf J.; Alban, Susanne; Boehncke, Wolf-Henning 2006
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Structure-function relation of efomycines, a family of small-molecule inhibitors of selectin functions Wienrich, B Gregor; Krahn, Thomas; Schon, Margarete; Rodriguez, Maria L.; ... Schon, Michael P. 2006
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Impact of species-dependent differences on screening, design, and development of MAO B inhibitors Novaroli, L.; Daina, Antoine; Favre, Elisabeth; Bravo, Juan; ... Reist, Marianne 2006
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Afibrinogénémie congénitale et contrôle de qualité de la sécrétion du fibrinogène Vu, Dung; Neerman Arbez, Marguerite 2006
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Novel RPLC stationary phases for lipophilicity measurement: solvatochromic analysis of retention mechanisms for neutral and basic compounds Stella, Cinzia; Galland, Alexandra; Liu, Xiangli; Testa, Bernard; ... Carrupt, Pierre-Alain 2005
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Structure-function analysis of the U2 snRNP-associated splicing factor SF3a Kraemer, Angela; Ferfoglia, Fabio; Huang, Ching-Jung; Mulhaupt, Flore; ... Tanackovic Abbas-Terki, Goranka 2005
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Engineering chemokines to develop optimized HIV inhibitors Hartley, Oliver; Offord, Robin Ewart 2005
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ProRule: a new database containing functional and structural information on PROSITE profiles Sigrist, Christian; De Castro, Eduardo; Langendijk Genevaux, Petra Simone; Le Saux, Virginie Anne Jeanne; ... Hulo, Nicolas 2005
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Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase Morokutti, Alexander; Lyskowski, Andrzej; Sollner, Sonja; Pointner, Eva; ... Macheroux, Peter 2005
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Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors Vacondio, F.; Mor, M.; Silva, C.; Zuliani, V.; ... Testa, Bernard 2004
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Liposome/water lipophilicity: methods, information content, and pharmaceutical applications van Balen, G. P.; Martinet, C. M.; Caron, Giulia; Bouchard, Geraldine; ... Testa, Bernard 2004
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Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors Hartley, Oliver; Gaertner, Hubert François; Wilken, Jill; Thompson, Darren; ... Offord, Robin Ewart 2004
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A short peptide at the amino terminus of the Sendai virus C protein acts as an independent element that induces STAT1 instability Garcin, Dominique; Marq, Jean-Baptiste; Iseni, Frédéric; Martin, Stephen; Kolakofsky, Daniel 2004
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Recent improvements to the PROSITE database Hulo, Nicolas; Sigrist, Christian; Le Saux, Virginie Anne Jeanne; Langendijk Genevaux, Petra Simone; ... Bairoch, Amos Marc 2004
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The amino-terminal extensions of the longer Sendai virus C proteins modulate pY701-Stat1 and bulk Stat1 levels independently of interferon signaling Garcin, Dominique; Marq, Jean-Baptiste; Goodbourn, Stephen; Kolakofsky, Daniel 2003
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Immobilized artificial membrane HPLC in drug research Taillardat-Bertschinger, Agnès; Carrupt, Pierre-Alain; Barbato, F.; Testa, Bernard 2003
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The relative partitioning of neutral and ionised compounds in sodium dodecyl sulfate micelles measured by micellar electrokinetic capillary chromatography Taillardat-Bertschinger, Agnès; Carrupt, Pierre-Alain; Testa, Bernard 2002
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Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. Synthesis and SAR studies Carotti, Angelo; Carrieri, A.; Chimichi, S.; Boccalini, M.; ... Testa, Bernard 2002
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Steady-state concentration of venlafaxine enantiomers: model-based analysis of between-patient variability Gex-Fabry, Marianne; Rudaz, Serge; Balant-Gorgia, Androniki E.; Brachet, Anne; ... Bertschy, Gilles 2002
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Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling Ooms, F.; Wouters, J.; Oscari, O.; Happaerts, T.; ... Lambert, D. M. 2002
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Role of the carboxyl terminal of connexin43 in transjunctional fast voltage gating Moreno, Alonso P; Chanson, Marc; Elenes, Sergio; Anumonwo, Justus; ... Delmar, Mario 2002
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Synthesis, purification and structural and functional characterization of recombinant form of a common genetic variant of human luteinizing hormone Manna, Pulak R; Joshi, Lata; Reinhold, Vernon N; Aubert, Michel; ... Huhtaniemi, Ilpo T 2002
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