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Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism Roomp, Kirsten; Kristinsson, Hjalti; Schvartz, Domitille; Ubhayasekera, Kumari; ... Bergsten, Peter 2017
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Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; ... Donath, Marc Y 2017
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Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose Johnston, Natalie R; Mitchell, Ryan K; Haythorne, Elizabeth; Pessoa, Maria Paiva; ... Hodson, David J 2016
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Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function Modi, Honey; Jacovetti, Cecile; Tarussio, David; Metref, Salima; ... Thorens, Bernard 2015
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A pancreatic clock times insulin release Dibner, Charna; Schibler, Ueli 2015
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Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells Rutti Roch, Sabine; Arous, Caroline; Nica, Alexandra C; Kanzaki, Makoto; ... Bouzakri, Karim 2014
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A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets Sileno, Sara; D'Oria, Valentina; Stucchi, Riccardo; Alessio, Massimo; ... Massa, Ornella 2014
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DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets Hall, Elin; Dayeh, Tasnim; Kirkpatrick, Clare; Wollheim, Claes; ... Ling, Charlotte 2013
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release Spégel, Peter; Sharoyko, Vladimir V; Goehring, Isabel; Danielsson, Anders P H; ... Mulder, Hindrik 2013
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Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction Bugliani, Marco; Liechti, Robin; Cheon, Hwanju; Suleiman, Mara; ... Marchetti, Piero 2013
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Nogo-A downregulation improves insulin secretion in mice Bonal, Claire Brune; Baronnier Caffe, Delphine; Pot, Caroline; Benkhoucha, Mahdia; ... Herrera, Pedro Luis 2013
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Hepatic glucose sensing is required to preserve β cell glucose competence Seyer, Pascal; Vallois, David; Poitry-Yamate, Carole; Schutz, Frédéric; ... Thorens, Bernard 2013
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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase Vetterli, Laurene Marine; Carobbio, Stefania; Pournourmohammadi, Shirin; Martin-Del-Rio, Rafael; ... Maechler, Pierre 2012
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The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice Zhang, Ye; Xie, Zhifang; Zhou, Luting; Li, Ling; ... Zhang, Weiping J 2012
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress Schvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles 2012
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Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells Akhmedov, Dmitry; De Marchi, Umberto; Wollheim, Claes; Wiederkehr, Andreas 2012
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Mitochondrial signals drive insulin secretion in the pancreatic β-cell Wiederkehr, Andreas; Wollheim, Claes 2012
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NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Li, Ning; Li, Bin; Brun, Thierry; Deffert-Delbouille, Christine; ... Maechler, Pierre 2012
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AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro, nor after transplantation into immunodeficient mice Merani, Shaheed; McCall, Michael; Pawlick, Rena L; Edgar, Ryan L; ... Shapiro, A M James 2011
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Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats Auer, Veronika J; Bucher, Julian; Schremmer-Danninger, Elisabeth; Paulmurugan, Ramasamy; ... Berger, Frank 2011
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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells Ellingsgaard, Helga; Hauselmann, Irina; Schuler, Beat; Habib, Abdella M; ... Donath, Marc Y 2011
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Rapamycin impairs proliferation of transplanted islet β cells Niclauss, Nadja; Bosco, Domenico; Morel, Philippe; Giovannoni, Laurianne; ... Parnaud, Géraldine 2011
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PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction Ravnskjaer, Kim; Frigerio, Francesca; Boergesen, Michael; Nielsen, Tina; ... Mandrup, Susanne 2010
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Role of mitochondria in beta-cell function and dysfunction Maechler, Pierre; Li, Ning; Casimir, Marina Shamini; Vetterli, Laurene Marine; ... Brun, Thierry 2010
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Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation Wallin, Tina; Ma, Zuheng; Ogata, Hirotaka; Jørgensen, Ingrid Hals; ... Björklund, Anneli 2010
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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism Frigerio, Francesca; Brun, Thierry; Bartley, C.; Usardi, A.; ... Maechler, Pierre 2010
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Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction Li, Ning; Brun, Thierry; Cnop, Miriam; Cunha, Daniel A.; ... Maechler, Pierre 2009
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Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets Casimir, Marina Shamini; Rubi, Blanca; Frigerio, Francesca; Chaffard, Gaelle; Maechler, Pierre 2009
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In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy Villiger, M.; Goulley, Joan; Friedrich, M.; Grapin-Botton, A.; ... Leitgeb, R. A. 2009
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Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells Rütti, Sabine; Ehses, Jan A.; Sibler, Rahel A.; Prazak, Richard; ... von Eckardstein, Arnold 2009
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Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets Pongratz, Rebecca L.; Kibbey, Richard G.; Kirkpatrick, Clare; Zhao, Xiaojian; ... Cline, Gary W. 2009
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Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells Mármol, Patricia; Pardo, Beatriz; Wiederkehr, Andreas; del Arco, Araceli; ... Satrústegui, Jorgina 2009
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Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function Hammar, Eva; Tomas, Alejandra; Bosco, Domenico; Halban, Philippe A. 2009
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The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice Emamaullee, Juliet A.; Davis, Joy; Pawlick, Rena; Toso, Christian; ... Shapiro, A M James 2008
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Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion Jaques, Fabienne; Jousset, Hélène; Tomas Catala, Alejandra Del Don; Prost, Anne-Lise; ... Halban, Philippe A. 2008
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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 Brun, Thierry; He, Kai Hui Hu; Lupi, Roberto; Boehm, Bernhard; ... Gauthier, Benoît 2008
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A new conditional mouse mutant reveals specific expression and functions of connexin36 in neurons and pancreatic beta-cells Wellershaus, Kerstin; Degen, Joachim; Deuchars, Jim; Theis, Martin; ... Willecke, Klaus 2008
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Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts Wojtusciszyn, Anne; Armanet, Mathieu Pierre Jean; Morel, Philippe; Berney, Thierry; Bosco, Domenico 2008
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Role of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate Louagie, Els; Taylor, N. A.; Flamez, Daisy; Roebroek, A. J.; ... Creemers, J. W. 2008
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Psoriasis patients show signs of insulin resistance Boehncke, Sandra; Thaci, Diamant; Beschmann, Heike; Ludwig, Ralf J.; ... Boehncke, Wolf-Henning 2007
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Mitochondrial GTP regulates glucose-stimulated insulin secretion Kibbey, Richard G; Pongratz, Rebecca L; Romanelli, Anthony J; Wollheim, Claes; ... Shulman, Gerald I 2007
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Proteomics analysis of insulin secretory granules Brunner, Yannick; Coute, Yohann; Iezzi-Bakhtiari, Mariella; Foti, Michelangelo; ... Sanchez, Jean-Charles 2007
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Inhibition of insulin secretion by betagranin, an N-terminal chromogranin A fragment Schmid, Gerhard M; Meda, Paolo; Caille, Dorothée; Wargent, Ed; ... Sanchez, Jean-Charles 2007
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Expectations and strategies regarding islet transplantation: metabolic data from the GRAGIL 2 trial Badet, Lionel; Benhamou, Pierre Y; Wojtusciszyn, Anne; Baertschiger, Reto Marc; ... Berney, Thierry 2007
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Pancreatic deletion of insulin receptor substrate 2 reduces beta and alpha cell mass and impairs glucose homeostasis in mice Cantley, J.; Choudhury, A. I.; Asare-Anane, H.; Selman, C.; ... Withers, D. J. 2007
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The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells Quoix, Nicolas; Cheng-Xue, Rui; Guiot, Yves; Herrera, Pedro Luis; ... Gilon, Patrick 2007
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Micro-ARN: ribo-régulateurs de l'homéostasie du glucose Gauthier, Benoît; Wollheim, Claes 2006
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Minireview: implication of mitochondria in insulin secretion and action Wiederkehr, Andreas; Wollheim, Claes 2006
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SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment Iezzi-Bakhtiari, Mariella; Theander, Sten; Janz, Roger; Loze, Chantal; Wollheim, Claes 2005
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Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Merglen, Arnaud; Theander, Sten; Rubi, Blanca; Chaffard, Gaelle; ... Maechler, Pierre 2004
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