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 TitleAuthors / EditorsDate
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Physiologically-based pharmacokinetic modeling for the prediction of CYP2D6-mediated gene-drug-drug interactions Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef 2019
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Towards personalized antithrombotic treatments: focus on P2Y12 inhibitors and direct oral anticoagulants Terrier, Jean; Daali, Youssef; Fontana, Pierre; Csajka, Chantal; Reny, Jean-Luc 2019
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Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approaches Magliocco, Gaëlle; Thomas, Aurélien; Desmeules, Jules Alexandre; Daali, Youssef 2019
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CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver content Lloret-Linares, Célia; Daali, Youssef; Abbara, Chadi; Carette, Claire; ... Declèves, Xavier 2019
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Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life Wilhelm-Bals, Alexandra Marina; Combescure, Christophe; Chehade, Hassib; Daali, Youssef; Parvex, Paloma Maria 2019
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Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef 2018
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Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef 2018
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Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report Aebischer, Gaspard; Ing Lorenzini, Kuntheavy; Tomala, Simon; Desmeules, Jules Alexandre; ... Samer, Caroline Flora 2018
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Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives Storelli, Flavia; Samer, Caroline Flora; Reny, Jean-Luc; Desmeules, Jules Alexandre; Daali, Youssef 2018
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Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites Marsousi, Niloufar; Daali, Youssef; Fontana, Pierre; Reny, Jean-Luc; ... Samer, Caroline Flora 2018
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Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance Choong, Eva; Uppugunduri, Chakradhara Rao Satyanarayana; Marino, Denis; Kuntzinger, Mélanie; ... Ansari Djaberi, Marc Georges 2018
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Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting Lloret-Linares, Célia; Bosilkovska Weisskopf, Marija; Daali, Youssef; Gex-Fabry, Marianne; ... Besson, Marie 2018
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Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study Lloret-Linares, Célia; Rollason Gumprecht, Victoria; Ing Lorenzini, Kuntheavy; Samer, Caroline Flora; ... Besson, Marie 2017
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Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane Transporters Cusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine 2017
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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases Romand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge 2017
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Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef 2017
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Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; ... Rostami-Hodjegan, A 2017
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Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus) Osorio Lujan, Suzanne; Habre, Walid; Daali, Youssef; Pan, Zhaoxin; Kronen, Peter W 2017
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The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation Uppugunduri, Chakradhara Rao S; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; ... Ansari Djaberi, Marc Georges 2017
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Impact of CYP2D6 functional allelic variations on phenoconversion and drug-drug interactions Storelli, Flavia; Matthey, Alain; Lenglet, Sébastien; Thomas, Aurélien; ... Daali, Youssef 2017
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Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study) Lloret-Linares, Célia; Daali, Youssef; Chevret, Sylvie; Nieto, Isabelle; ... Bellivier, Frank 2017
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Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study Bosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy; Uppugunduri Satyanarayana, Chakradhara Rao; Desmeules, Jules Alexandre; ... Escher, Monica 2016
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Pharmacogenomics of Oral Antithrombotic Drugs Storelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre 2016
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An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure Spaggiari, Dany; Daali, Youssef; Rudaz, Serge 2016
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells Marsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef 2016
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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia Ralvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie 2016
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach Marsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef 2016
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Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef 2016
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Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis Seredenin, Tamara; Nayernia, Zeynab; Sorce, Silvia; Maghzal, Ghassan J; ... Jaquet, Vincent 2016
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Detection of busulfan adducts on proteins Acosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; ... Lescuyer, Pierre 2016
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Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect Ing Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora 2016
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Aspirin response: Differences in serum thromboxane B2 levels between clinical studies Brun, Charlotte; Daali, Youssef; Combescure, Christophe; Zufferey Bakos, Anne; ... Frelinger, Andrew L (3rd) 2016
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Augmented renal clearance, low β-lactam concentrations and clinical outcomes in the critically ill: An observational prospective cohort study Csaki Huttner, Angela; Von Dach, Elodie; Renzoni, Adriana Maria; Huttner, Benedikt; ... Harbarth, Stéphan Juergen 2015
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Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review Bouatou, Yassine; Samer, Caroline Flora; Fontana, Pierre; Daali, Youssef; Desmeules, Jules Alexandre 2015
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Markers of Individual Drug Metabolism: Towards the Development of a Personalized Antidepressant Prescription Lloret-Linares, Celia; Bellivier, Frank; Haffen, Emmanuel; Aubry, Jean-Michel; ... Besson, Marie 2015
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GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers Besson, Marie; Matthey, Alain; Daali, Youssef; Poncet, Antoine; ... Desmeules, Jules Alexandre 2015
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Role of paraoxonase-1 in CYP2C19 loss-of-function carriers Daali, Youssef; Reny, Jean-Luc; Fontana, Pierre 2014
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Antiplatelet Therapy: Targeting the TxA2 Pathway Fontana, Pierre; Zufferey Bakos, Anne; Daali, Youssef; Reny, Jean-Luc 2014
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Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spots Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Rebsamen, Michela; ... Daali, Youssef 2014
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Incorporation of Flurbiprofen in a 4-Drug Cytochrome P450 Phenotyping Cocktail Bosilkovska Weisskopf, Marija; Clement, Mallorie; Dayer, Pierre; Desmeules, Jules Alexandre; Daali, Youssef 2014
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Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review Rollason Gumprecht, Victoria; Samer, Caroline Flora; Daali, Youssef; Desmeules, Jules Alexandre 2014
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Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activity Bouatou, Yassine; Samer, Caroline Flora; Ing Lorenzini, Kuntheavy Roseline; Daali, Youssef; ... Escher, Monica 2014
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Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma Bosilkovska Weisskopf, Marija; Deglon, Julien; Samer, Caroline Flora; Walder, Bernhard; ... Daali, Youssef 2014
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The association of cytochrome P450 genetic polymorphisms with sulfolane formation and the efficacy of a busulfan-based conditioning regimen in pediatric patients undergoing hematopoietic stem cell transplantation Uppugunduri Satyanarayana, Chakradhara Rao; Rezgui, M; Diaz, PH; Tyagi, Anuj Kumar; ... Ansari Djaberi, Marc Georges 2014
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Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic Model Marsousi, Niloufar; Daali, Youssef; Rudaz, Serge; Almond, L; ... Samer, Caroline Flora 2014
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A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologies Spaggiari, Dany; Geiser, Laurent; Daali, Youssef; Rudaz, Serge 2014
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Phenotyping of CYP450 in human liver microsomes using the cocktail approach Spaggiari, Dany; Geiser, Laurent; Daali, Youssef; Rudaz, Serge 2014
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Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute pain Ehret, Georg Benedikt; Daali, Youssef; Chabert, Jocelyne; Rebsamen, Michela; ... Desmeules, Jules Alexandre 2013
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Antihyperalgesic Effect of the GABA(A) Ligand Clobazam in a Neuropathic Pain Model in Mice: A Pharmacokinetic-Pharmacodynamic Study Besson, Marie; Daali, Youssef; Di Lio, Alessandra; Dayer, Pierre; ... Desmeules, Jules Alexandre 2013
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Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteers Ancrenaz, Virginie; Deglon, Julien; Samer, Caroline Flora; Staub, Christian Olivier; ... Desmeules, Jules Alexandre 2013
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