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L’exposition des cellules bêta au fructose potentialise la sécrétion d’insuline via une signalisation par l’ATP Brun, Thierry; Bartley, Clarissa; Maechler, Pierre 2019
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Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion Casimir, Marina Shamini; Chaffard, Gaelle; Maechler, Pierre 2019
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In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way Li, Lingzi; Martin-Levilain, Juliette; Jimenez-Sanchez, Cécilia; Karaca Emre, Melis; ... Maechler, Pierre 2019
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Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis Martin-Levilain, Juliette; Li, Lingzi; Maechler, Pierre 2019
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Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction Lander, Sharon S; Khan, Usman; Lewandowski, Nicole; Chakraborty, Darpan; ... Gaisler-Salomon, Inna 2019
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Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset Li, Lingzi; Krznar, Petra; Erban, Alexander; Agazzi, Andréa; ... Maechler, Pierre 2019
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Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling Bartley, Clarissa; Brun, Thierry; Oberhauser, Lucie; Grimaldi, Mariagrazia; ... Maechler, Pierre 2019
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Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis Karaca Emre, Melis; Martin-Levilain, Juliette; Grimaldi, Mariagrazia; Li, Lingzi; ... Maechler, Pierre 2018
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Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation Hohnholt, Michaela C; Andersen, Vibe H; Andersen, Jens V; Christensen, Sofie K; ... Waagepetersen, Helle S 2018
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Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia Grimaldi, Mariagrazia; Karaca Emre, Melis; Latini, Livia; Brioudes, Estelle; ... Maechler, Pierre 2017
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Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state? Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; ... Maechler, Pierre 2017
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Glutamate pathways of the beta-cell and the control of insulin secretion Maechler, Pierre 2017
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Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; ... Donath, Marc Y 2017
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Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions Kaczmarek, P; Skrzypski, M; Pruszynska-Oszmalek, E; Sassek, M; ... Strowski, M Z 2017
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Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression Brun, Julia; Berthou, Flavien; Trajkovski, Mirko; Maechler, Pierre; ... Bonnet, Nicolas 2017
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Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity Li, Ning; Karaca Emre, Melis; Maechler, Pierre 2017
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The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity Vetterli, Laurene Marine; Carobbio, Stefania; Frigerio, Francesca; Karaca Emre, Melis; Maechler, Pierre 2016
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Beta-cell mitochondrial carriers and the diabetogenic stress response Brun, Thierry; Maechler, Pierre 2016
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Channels and transporters in cell metabolism Sonveaux, Pierre; Maechler, Pierre; Martinou, Jean-Claude 2016
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Activation of nicotinic acetylcholine receptors decreases apoptosis in human and female murine pancreatic islets Klee, Philippe; Bosco, Domenico; Guerardel, Audrey; Somm, Emmanuel; ... Schwitzgebel Luscher, Valérie 2016
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Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells Schmidt, Søren Fisker; Madsen, Jesper Grud Skat; Frafjord, Kari Østerli; Poulsen, Lars la Cour; ... Mandrup, Susanne 2016
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Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells Aragón, F; Karaca Emre, Melis; Novials, A; Maldonado, R; ... Rubí, B 2015
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Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs? Wollheim, Claes; Maechler, Pierre 2015
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Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets Brun, Thierry; Li, Ning; Jourdain, Alexis; Gaudet, Pascale; ... Maechler, Pierre 2015
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GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution Karaca Emre, Melis; Frigerio, Francesca; Migrenne, Stephanie; Martin-Levilain, Juliette; ... Maechler, Pierre 2015
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Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite 2015
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Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite 2015
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A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets Sileno, Sara; D'Oria, Valentina; Stucchi, Riccardo; Alessio, Massimo; ... Massa, Ornella 2014
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Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E. Russo, Lucia; Marsella, Claudia; Nardo, Giovanni; Massignan, Tania; ... Massa, Ornella 2013
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Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB. Zhang, Yanling; Zhen, Wei; Maechler, Pierre; Liu, Dongmin 2013
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Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development Supale, Sachin; Thorel, Fabrizio; Merkwirth, Carsten; Gjinovci, Asllan; ... Maechler, Pierre 2013
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Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids Brun, Thierry; Scarcia, Pasquale; Li, Ning; Gaudet, Pascale; ... Maechler, Pierre 2013
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Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter Karaca Emre, Melis; Maechler, Pierre 2013
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Mitochondrial function and insulin secretion Maechler, Pierre 2013
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Hepatic glucose sensing is required to preserve β cell glucose competence Seyer, Pascal; Vallois, David; Poitry-Yamate, Carole; Schutz, Frédéric; ... Thorens, Bernard 2013
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Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role? Li, Ning; Stojanovski, Suzana; Maechler, Pierre 2012
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Mitochondria in endocrinology Maechler, Pierre 2012
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Mitochondrial signal transduction in pancreatic β-cells Maechler, Pierre 2012
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Procyanidins modify insulinemia by affecting insulin production and degradation Castell-Auví, Anna; Cedó, Lídia; Pallarès, Victor; Blay, M Teresa; ... Ardévol, Anna 2012
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Mitochondrial dysfunction in pancreatic β cells Supale, Sachin; Li, Ning; Brun, Thierry; Maechler, Pierre 2012
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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase Vetterli, Laurene Marine; Carobbio, Stefania; Pournourmohammadi, Shirin; Martin-Del-Rio, Rafael; ... Maechler, Pierre 2012
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Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission Frigerio, Francesca Alda; Karaca Emre, Melis; De Roo, Mathias; Mlynárik, Vladimír; ... Maechler, Pierre 2012
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NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Li, Ning; Li, Bin; Brun, Thierry; Deffert-Delbouille, Christine; ... Maechler, Pierre 2012
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ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells Boergesen, Michael; Poulsen, Lars la Cour; Schmidt, Søren Fisker; Frigerio, Francesca; ... Mandrup, Susanne 2011
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Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis Vetterli, Laurene Marine; Maechler, Pierre 2011
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From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis Karaca Emre, Melis; Frigerio, Francesca; Maechler, Pierre 2011
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Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells Račková, Lucia; Cumaoğlu, Ahmet; Bağrıacık, E Umit; Štefek, Milan; ... Karasu, Çimen 2011
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Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats Auer, Veronika J; Bucher, Julian; Schremmer-Danninger, Elisabeth; Paulmurugan, Ramasamy; ... Berger, Frank 2011
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Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells Cumaoğlu, Ahmet; Rackova, Lucia; Stefek, Milan; Kartal, Murat; ... Karasu, Cimen 2011
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A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes Casimir, Marina Shamini; de Andrade, Paula B; Gjinovci, Asllan; Montani, Jean-Pierre; ... Dulloo, Abdul G 2011
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