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Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells Mármol, Patricia; Pardo, Beatriz; Wiederkehr, Andreas; del Arco, Araceli; ... Satrústegui, Jorgina 2009
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Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets Pongratz, Rebecca L.; Kibbey, Richard G.; Kirkpatrick, Clare; Zhao, Xiaojian; ... Cline, Gary W. 2009
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Low- and high-density lipoproteins modulate function, apoptosis, and proliferation of primary human and murine pancreatic beta-cells Rütti, Sabine; Ehses, Jan A.; Sibler, Rahel A.; Prazak, Richard; ... von Eckardstein, Arnold 2009
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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism Frigerio, Francesca; Brun, Thierry; Bartley, C.; Usardi, A.; ... Maechler, Pierre 2010
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PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction Ravnskjaer, Kim; Frigerio, Francesca; Boergesen, Michael; Nielsen, Tina; ... Mandrup, Susanne 2010
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Role of mitochondria in beta-cell function and dysfunction Maechler, Pierre; Li, Ning; Casimir, Marina Shamini; Vetterli, Laurene Marine; ... Brun, Thierry 2010
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Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation Wallin, Tina; Ma, Zuheng; Ogata, Hirotaka; Jørgensen, Ingrid Hals; ... Björklund, Anneli 2010
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AEB071 (sotrastaurin) does not exhibit toxic effects on human islets in vitro, nor after transplantation into immunodeficient mice Merani, Shaheed; McCall, Michael; Pawlick, Rena L; Edgar, Ryan L; ... Shapiro, A M James 2011
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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells Ellingsgaard, Helga; Hauselmann, Irina; Schuler, Beat; Habib, Abdella M; ... Donath, Marc Y 2011
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Rapamycin impairs proliferation of transplanted islet β cells Niclauss, Nadja; Bosco, Domenico; Morel, Philippe; Giovannoni, Laurianne; ... Parnaud, Géraldine 2011
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Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats Auer, Veronika J; Bucher, Julian; Schremmer-Danninger, Elisabeth; Paulmurugan, Ramasamy; ... Berger, Frank 2011
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NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion Li, Ning; Li, Bin; Brun, Thierry; Deffert-Delbouille, Christine; ... Maechler, Pierre 2012
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress Schvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles 2012
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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase Vetterli, Laurene Marine; Carobbio, Stefania; Pournourmohammadi, Shirin; Martin-Del-Rio, Rafael; ... Maechler, Pierre 2012
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The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice Zhang, Ye; Xie, Zhifang; Zhou, Luting; Li, Ling; ... Zhang, Weiping J 2012
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Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells Akhmedov, Dmitry; De Marchi, Umberto; Wollheim, Claes; Wiederkehr, Andreas 2012
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Mitochondrial signals drive insulin secretion in the pancreatic β-cell Wiederkehr, Andreas; Wollheim, Claes 2012
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Nogo-A downregulation improves insulin secretion in mice Bonal, Claire Brune; Baronnier Caffe, Delphine; Pot, Caroline; Benkhoucha, Mahdia; ... Herrera, Pedro Luis 2013
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Hepatic glucose sensing is required to preserve β cell glucose competence Seyer, Pascal; Vallois, David; Poitry-Yamate, Carole; Schutz, Frédéric; ... Thorens, Bernard 2013
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Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction Bugliani, Marco; Liechti, Robin; Cheon, Hwanju; Suleiman, Mara; ... Marchetti, Piero 2013
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