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Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patients Migliorini, Denis; Dutoit Vallotton, Valérie; Allard, Mathilde Camille; Grandjean Hallez, Nicole; ... Dietrich, Pierre-Yves 2019
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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease Mrdjen, Dunja; Pavlovic, Anto; Hartmann, Felix J; Schreiner, Bettina; ... Becher, Burkhard 2018
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Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent Manner Datta, Moumita; Staszewski, Ori; Raschi, Elena; Frosch, Maximilian; ... Prinz, Marco 2018
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The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells Moalli, Federica; Ficht, Xenia; Germann, Philipp; Vladymyrov, Mykhailo; ... Stein, Jens V 2018
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Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report El-Ayadi, Moatasem; Egervari, Kristof Levente; Merkler, Doron; Mckee, Thomas Alexander; ... Von Bueren, André 2018
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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping Di Liberto, Giovanni; Pantelyushin, Stanislav; Kreutzfeldt, Mario; Page, Nicolas; ... Merkler, Doron 2018
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The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research Steinemann, Nina; Kuhle, Jens; Calabrese, Pasquale; Kesselring, Jürg; ... von Wyl, Viktor 2018
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Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal Circuits Loy, Kristina; Schmalz, Anja; Hoche, Tobias; Jacobi, Anne; ... Bareyre, Florence M 2018
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Resident-memory T cells in tissue-restricted immune responses: for better or worse? Steinbach, Karin; Vincenti, Ilena; Merkler, Doron 2018
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunity Knier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; ... Korn, Thomas 2018
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Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements Fabbiano, Salvatore; Suarez Zamorano, Nicolas; Chevalier, Claire; Lazarevic, Vladimir; ... Trajkovski, Mirko 2018
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Expression of the DNA-Binding Factor TOX Promotes the Encephalitogenic Potential of Microbe-Induced Autoreactive CD8+ T Cells Page, Nicolas; Klimek, Bogna; De Roo, Mathias; Steinbach, Karin; ... Merkler, Doron 2018
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Increased interleukin-27 cytokine expression in the central nervous system of multiple sclerosis patients Lalive d'Epinay, Patrice; Kreutzfeldt, Mario; Devergne, Odile; Metz, Imke; ... Pot, Caroline 2017
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STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells Nunes-Hasler, Paula; Maschalidi, Sophia; Lippens, Carla; Castelbou, Cyril; ... Demaurex, Nicolas 2017
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Germline PMS2 and somatic POLEexo mutations cause hypermutability of the leading DNA strand in Biallelic Mismatch Repair Deficiency syndrome brain tumors Andrianova, Maria A; Chetan, Ghati Kasturirangan; Sibin, Madathan Kandi; Mckee, Thomas Alexander; ... Nikolaev, Sergey Igorievich 2017
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The Immune System Bridges the Gut Microbiota with Systemic Energy Homeostasis: Focus on TLRs, Mucosal Barrier, and SCFAs Spiljar, Martina; Merkler, Doron; Trajkovski, Mirko 2017
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Replicating viral vector platform exploits alarmin signals for potent CD8(+) T cell-mediated tumour immunotherapy Kallert, Sandra M; Darbre, Stéphanie; Bonilla, Weldy V; Kreutzfeldt, Mario; ... Pinschewer, Daniel 2017
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Clival chordoma: a single-centre outcome analysis Jaegersberg, Max; El Rahal, Amir Mohamed; Dammann, Philipp; Merkler, Doron; ... Schaller, Karl Lothard 2017
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Interferon-γ-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever Remy, Mélissa; Sahin, Mehmet; Flatz, Lukas Roland; Regen, Tommy; ... Pinschewer, Daniel 2017
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B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation Bjarnadottir, Kristbjorg; Benkhoucha, Mahdia; Merkler, Doron; Weber, Martin S; ... Lalive d'Epinay, Patrice 2016
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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis Jürgens, Tanja; Jafari, Mehrnoosh; Kreutzfeldt, Mario; Bahn, Erik; ... Merkler, Doron 2016
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Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model Romanelli, Elisa; Merkler, Doron; Mezydlo, Aleksandra; Weil, Marie-Theres; ... Kerschensteiner, Martin 2016
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pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion Ozga, Aleksandra J; Moalli, Federica; Abe, Jun; Swoger, Jim; ... Koritzinsky, Marianne 2016
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pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation Duraes, Fernanda V; Lippens, Carla; Steinbach, Karin; Dubrot Armendariz, Juan; ... Hugues, Stéphanie 2016
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In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology Herwerth, Marina; Kalluri, Sudhakar Reddy; Srivastava, Rajneesh; Kleele, Tatjana; ... Hemmer, Bernhard 2016
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TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells Parsa, Roham; Lund, Harald; Tosevski, Ivana; Zhang, Xing-Mei; ... Harris, Robert A 2016
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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection Steinbach, Karin; Vincenti, Ilena; Kreutzfeldt, Mario; Page, Nicolas; ... Merkler, Doron 2016
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Interferon-driven deletion of antiviral B cells at the onset of chronic infection Fallet, Benedict; Narr, Kerstin; Ertuna, Yusuf I; Remy, Mélissa; ... Pinschewer, Daniel 2016
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Medulloblastoma in children and adults: one distinct disease entity? Von Bueren, André; Ares Molina, Carmen; Bartoli, Andréa; Fluss, Joel Victor; ... Ansari Djaberi, Marc Georges 2016
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Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses Loi, Monica; Müller, Anne; Steinbach, Karin; Niven, Jennifer; ... Gannagé, Monique 2016
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Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity Chalmin, Fanny; Rochemont, Viviane; Lippens, Carla; Clottu, Aurélie Sarah; ... Pot, Caroline 2015
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain Goldmann, Tobias; Zeller, Nicolas; Raasch, Jenni; Kierdorf, Katrin; ... Prinz, Marco 2015
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Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage Bhattacharya, Anannya; Hegazy, Ahmed N; Deigendesch, Nikolaus; Kosack, Lindsay; ... Bergthaler, Andréas 2015
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IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling Peters, Anneli; Fowler, Kevin D; Chalmin, Fanny; Merkler, Doron; ... Pot, Caroline 2015
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The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection Schliehe, Christopher; Flynn, Elizabeth K; Vilagos, Bojan; Richson, Udochuku; ... Bergthaler, Andréas 2015
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Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review Migliorini, Denis; Haller, Sven; Merkler, Doron; Pugliesi-Rinaldi, Angela; ... Dietrich, Pierre-Yves 2015
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TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3(+) Treg cells Lalive, PH; Benkhoucha, Mahdia; Tran, Ngoc Lan; Kreutzfeldt, Mario; ... Santiago-Raber, Marie-Laure 2014
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Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue Snaidero, Nicolas; Möbius, Wiebke; Czopka, Tim; Hekking, Liesbeth H.P.; ... Simons, Mikael 2014
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Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells Benkhoucha, Mahdia; Molnarfi, Nicolas; Dunand-Sauthier, Isabelle; Merkler, Doron; ... Lalive d'Epinay, Patrice 2014
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Pervasive Axonal Transport Deficits in Multiple Sclerosis Models Sorbara, Catherine Diamante; Wagner, Naomi Elizabeth; Ladwig, Anne; Nikić, Ivana; ... Kerschensteiner, Martin 2014
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Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) Steinbach, Karin; Merkler, Doron 2014
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Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination Rodriguez, Enrique Garea; Wegner, Christiane; Kreutzfeldt, Mario; Neid, Katharina; ... Merkler, Doron 2014
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Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis Du Pasquier, Renaud A.; Pinschewer, Daniel; Merkler, Doron 2014
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Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions Schirmer, Lucas; Merkler, Doron; König, Fatima B; Brück, Wolfgang; Stadelmann, Christine 2013
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Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis Serres, Sébastien; Bristow, Claire; de Pablos, Rocío M; Merkler, Doron; ... Anthony, Daniel C 2013
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Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers Rieger, Toni; Merkler, Doron; Günther, Stephan 2013
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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss Kreutzfeldt, Mario; Bergthaler, Andréas; Fernandez, Marylise; Brück, Wolfgang; ... Merkler, Doron 2013
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Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature Daou, Samira; Ambrosioni Czyrko, Juan; Merkler, Doron; Calmy, Alexandra 2013
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Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior Peruga, Isabella; Hartwig, Silvia; Merkler, Doron; Thöne, Jan; ... Linker, Ralf A 2012
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The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses Bonilla, Weldy V; Fröhlich, Anja; Senn, Karin; Kallert, Sandra; ... Pinschewer, Daniel 2012
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