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 TitleAuthors / EditorsDate
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Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose Johnston, Natalie R; Mitchell, Ryan K; Haythorne, Elizabeth; Pessoa, Maria Paiva; ... Hodson, David J 2016
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Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells Rutti Roch, Sabine; Arous, Caroline; Nica, Alexandra C; Kanzaki, Makoto; ... Bouzakri, Karim 2014
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A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets Sileno, Sara; D'Oria, Valentina; Stucchi, Riccardo; Alessio, Massimo; ... Massa, Ornella 2014
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Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release Spégel, Peter; Sharoyko, Vladimir V; Goehring, Isabel; Danielsson, Anders P H; ... Mulder, Hindrik 2013
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Effects of high glucose-induced Cx43 downregulation on occludin and ZO-1 expression and tight junction barrier function in retinal endothelial cells Tien, Thomas; Barrette, Kevin F; Chronopoulos, Argyrios; Roy, Sayon 2013
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress Schvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles 2012
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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes Mahdi, Taman; Hänzelmann, Sonja; Salehi, Albert; Muhammed, Sarheed J; ... Rosengren, Anders H 2012
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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes Yang, Beatrice T; Dayeh, Tasnim A; Volkov, Petr A; Kirkpatrick, Clare; ... Ling, Charlotte 2012
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Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion Rondas, Dieter; Tomas Catala, Alejandra Del Don; Soto Ribeiro, Martinho; Wehrle-Haller, Bernhard; Halban, Philippe A. 2012
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Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin Rondas, Dieter; Tomas, Alejandra; Halban, Philippe A. 2011
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Glucagon responses of isolated α cells to glucose, insulin, somatostatin, and leptin Chen, Lijun; Philippe, Jacques; Unger, Roger H 2011
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The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells de Leeuw van Weenen, J. E.; Parlevliet, E. T.; Maechler, Pierre; Havekes, L. M.; ... Guigas, B. 2010
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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells Akhmedov, Dmitry; Braun, Matthias; Mataki, Chikage; Park, Kyu-Sang; ... Wiederkehr, Andreas 2010
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Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI Ris, Frédéric; Lepetit-Coiffe, Matthieu; Meda, Paolo; Crowe, Lindsey; ... Berney, Thierry 2010
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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism Frigerio, Francesca; Brun, Thierry; Bartley, C.; Usardi, A.; ... Maechler, Pierre 2010
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Regulation of insulin secretion by phosphatidylinositol-4,5-bisphosphate Tomas, Alejandra; Yermen, Barbara; Regazzi, Romano; Pessin, J. E.; Halban, Philippe A. 2010
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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism Bender, Katrin; Maechler, Pierre; McClenaghan, Neville H.; Flatt, Peter R.; Newsholme, Philip 2009
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Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets Pongratz, Rebecca L.; Kibbey, Richard G.; Kirkpatrick, Clare; Zhao, Xiaojian; ... Cline, Gary W. 2009
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Independent evolution of heart autonomic function and insulin sensitivity during weight loss Bobbioni-Harsch, Elisabetta; Sztajzel, Juan; Barthassat, Vincent; Makoundou, Vincent; ... Golay, Alain 2009
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Role of the Rho-ROCK (Rho-associated kinase) signaling pathway in the regulation of pancreatic beta-cell function Hammar, Eva; Tomas, Alejandra; Bosco, Domenico; Halban, Philippe A. 2009
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The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice Emamaullee, Juliet A.; Davis, Joy; Pawlick, Rena; Toso, Christian; ... Shapiro, A M James 2008
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Dual effect of cell-cell contact disruption on cytosolic calcium and insulin secretion Jaques, Fabienne; Jousset, Hélène; Tomas Catala, Alejandra Del Don; Prost, Anne-Lise; ... Halban, Philippe A. 2008
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Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation Böni-Schnetzler, Marianne; Thorne, Jeffrey; Parnaud, Géraldine; Marselli, Lorella; ... Donath, Marc Y. 2008
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The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1 Brun, Thierry; He, Kai Hui Hu; Lupi, Roberto; Boehm, Bernhard; ... Gauthier, Benoît 2008
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Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets Jabs, N.; Franklin, Isobel; Brenner, M. B.; Gromada, J.; ... Lammert, E. 2008
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Pancreatic insulin content regulation by the estrogen receptor ER alpha Alonso-Magdalena, Paloma; Ropero, Ana B.; Carrera, M Pilar; Cederroth, Christopher; ... Nadal, Angel 2008
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Mitochondrial GTP regulates glucose-stimulated insulin secretion Kibbey, Richard G; Pongratz, Rebecca L; Romanelli, Anthony J; Wollheim, Claes; ... Shulman, Gerald I 2007
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Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation Mathe, Zoltan; Dupraz, Philippe Victor Leon; Rinsch, Chris; Thorens, Bernard; ... Pepper, Michael Sean 2006
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Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 Maedler, Kathrin; Schumann, Desiree; Schulthess, Fabienne; Oberholzer, José; ... Donath, Marc Y 2006
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Regulation of pancreatic beta-cell insulin secretion by actin cytoskeleton remodelling: role of gelsolin and cooperation with the MAPK signalling pathway Tomas, Alejandra; Yermen, Barbara; Min, Le; Pessin, J. E.; Halban, Philippe A. 2006
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SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment Iezzi-Bakhtiari, Mariella; Theander, Sten; Janz, Roger; Loze, Chantal; Wollheim, Claes 2005
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Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues Winzell, Maria Sörhede; Pacini, Giovanni; Wollheim, Claes; Ahrén, Bo 2004
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Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Merglen, Arnaud; Theander, Sten; Rubi, Blanca; Chaffard, Gaelle; ... Maechler, Pierre 2004
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Pioglitazone and sodium salicylate protect human beta-cells against apoptosis and impaired function induced by glucose and interleukin-1beta Zeender, Eve Salome; Maedler, K.; Bosco, Domenico; Berney, Thierry; ... Halban, Philippe A. 2004
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Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function Maedler, Kathrin; Oberholzer, José; Bucher, Pascal Alain Robert; Spinas, Giatgen A; Donath, Marc 2003
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Differential gene expression in well-regulated and dysregulated pancreatic beta-cell (MIN6) sublines Lilla, Valerie; Webb, Gene; Rickenbach, Katharina; Maturana, Andrés; ... Irminger, Jean-Claude 2003
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Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway Lenssen, Eve; Oberholzer, Ursula; Labarre, J; De Virgilio, Claudio; Collart, Martine 2002
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Dominant-negative suppression of HNF-1 alpha results in mitochondrial dysfunction, INS-1 cell apoptosis, and increased sensitivity to ceramide-, but not to high glucose-induced cell death Wobser, Hella; Düssmann, Heiko; Kögel, Donat; Wang, Haiyan; ... Prehn, Jochen H M 2002
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Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues Antinozzi, Peter; Ishihara, Hisamitsu; Newgard, Christopher B; Wollheim, Claes 2002
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Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix Bosco, Domenico; Gonelle-Gispert, C.; Wollheim, Claes; Halban, Philippe A.; Rouiller, Dominique 2001
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Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrin Bosco, Domenico; Meda, Paolo; Halban, Philippe A.; Rouiller, Dominique 2000
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Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell Maechler, Pierre; Wollheim, Claes 2000
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Hyperglycemia-induced vasculopathy in the murine vitelline vasculature: correlation with PECAM-1/CD31 tyrosine phosphorylation state Pinter, E.; Mahooti, S.; Wang, Y.; Imhof, Beat; Madri, J. A. 1999
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Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells Maechler, Pierre; Jornot, L; Wollheim, Claes 1999
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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells Ishihara, Hisamitsu; Wang, Haiyan; Drewes, L R; Wollheim, Claes 1999
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Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release Kennedy, Eleanor; Wollheim, Claes 1998
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Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells Kennedy, Eleanor; Rizzuto, R; Theler, J M; Pralong, William; ... Wollheim, Claes 1996
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Oscillations of cytosolic free calcium in bombesin-stimulated HIT-T15 cells Li, Guodong; Wollheim, Claes; Pralong, William 1996
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pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle Orci, Lelio; Halban, Philippe A.; Perrelet, Alain; Amherdt, M.; ... Anderson, R. G. 1994
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Tumor necrosis factor-alpha modifies adhesion properties of rat islet B cells Cirulli, V.; Halban, Philippe A.; Rouiller, Dominique 1993
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