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In vitro demonstration of a particular affinity of glomerular basement membrane and collagen for DNA. A possible basis for a local formation of DNA-anti-DNA complexes in systemic lupus erythematosus Izui, Shozo; Lambert, Paul Henri; Miescher, P. A. 1976
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Influence of lipophilicity and chirality on the selectivity of ligands for beta 1- and beta 2-adrenoceptors el Tayar, Nabil; Testa, Bernard; Van de Waterbeemd, Hans; Carrupt, Pierre-Alain; Kaumann, A. J. 1988
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Separation of solubilized A2 adenosine receptors of human platelets from non-receptor [3H]NECA binding sites by gel filtration Lohse, Martin J.; Elger, Bernice Simone; Lindenborn-Fotinos, Jutta; Klotz, Karl Norbert; Schwabe, Ulrich 1988
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Lipophilicity and conformational behaviour of substituted xanthines Walther, B.; Carrupt, Pierre-Alain; Van de Waterbeemd, Hans; el Tayar, Nabil; Testa, Bernard 1989
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Isolation of high-affinity murine interleukin 2 receptors as detergent-resistant membrane complexes Hoessli, Daniel; Poincelet, Monique; Rungger-Brandle, Elisabeth 1990
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Percutaneous penetration of drugs: a quantitative structure-permeability relationship study el Tayar, Nabil; Tsai, Ruey-Shiuan; Testa, Bernard; Carrupt, Pierre-Alain; ... Leo, A. 1991
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Rab GDI: a solubilizing and recycling factor for rab9 protein Soldati, Thierry; Riederer, M A; Pfeffer, S R 1993
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Effects of solvation on the ionization and conformation of raclopride and other antidopaminergic 6-methoxysalicylamides: insight into the pharmacophore Tsai, Ruey-Shiuan; Carrupt, Pierre-Alain; Testa, Bernard; Gaillard, Patrick; ... Hogberg, Thomas 1993
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Molecular lipophilicity potential, a tool in 3D QSAR: method and applications Gaillard, Patrick; Carrupt, Pierre-Alain; Testa, Bernard; Boudon, Alain 1994
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Synthesis and in vitro study of a diglyceride prodrug of a peptide Delie Salmon, Florence; Couvreur, P; Nisato, D; Michel, J B; ... Letourneux, Y 1994
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Structure-affinity relationships of baclofen and 3-heteroaromatic analogues Pirard, B.; Carrupt, Pierre-Alain; Testa, Bernard; Tsai, Ruey-Shiuan; ... Durant, F. 1995
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Esters of L-dopa: structure-hydrolysis relationships and ability to induce circling behaviour in an experimental model of hemiparkinsonism Brunner-Guenat, M.; Carrupt, Pierre-Alain; Lisa, G.; Testa, Bernard; ... Ventura, P. 1995
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A cellular automata model of the hydrophobic effect Kier, Lemont B.; Cheng, Chao-Kun; Testa, Bernard; Carrupt, Pierre-Alain 1995
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X-ray crystal structure, partitioning behavior, and molecular modeling study of piracetam-type nootropics: insights into the pharmacophore Altomare, Cosimo; Cellamare, S.; Carotti, Angelo; Casini, G.; ... Testa, Bernard 1995
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Lipophilicity in molecular modeling Testa, Bernard; Carrupt, Pierre-Alain; Gaillard, Patrick; Billois, F.; Weber, P. 1996
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Photodynamic therapy of tumours with hexadecafluoro zinc phthalocynine formulated in PEG-coated poly(lactic acid) nanoparticles Allémann, Eric; Rousseau, Jacques; Brasseur, Nicole; Kudrevich, Svetlana V.; ... van Lier, Johan E. 1996
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Store-operated Ca2+ influx: what is the message from the stores to the membrane? Favre, C. J.; Nusse, Olivier; Lew, Daniel Pablo; Krause, Karl-Heinz 1996
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A systems approach to molecular structure, intermolecular recognition, and emergence-dissolvence in medicinal research Testa, Bernard; Kier, Lemont B.; Carrupt, Pierre-Alain 1997
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Prevention of autoimmune diabetes mellitus in NOD mice by transgenic expression of soluble tumor necrosis factor receptor p55 Hunger, R. E.; Carnaud, C.; Garcia, Irène; Vassalli, Pierre; Mueller, Christian 1997
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Soluble form of complement C3b/C4b receptor (CR1) results from a proteolytic cleavage in the C-terminal region of CR1 transmembrane domain Hamer, I.; Paccaud, Jean-Pierre; Belin, Dominique; Maeder, C.; Carpentier, J. L. 1998
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Partial solubility parameters of piroxicam and niflumic acid Bustamante, P.; Peña, M.; Barra, Jérôme 1998
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The pH-partition profile of the anti-ischemic drug trimetazidine may explain its reduction of intracellular acidosis Reymond, F.; Steyaert, G.; Carrupt, Pierre-Alain; Morin, D.; ... Testa, Bernard 1999
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Concomitant and controlled release of dexamethasone and 5-fluorouracil from poly(ortho ester) Einmahl, Suzanne; Zignani, M.; Varesio, Emmanuel; Heller, J.; ... Gurny, Robert 1999
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Signal transduction via CD44: role of plasma membrane microdomains Ilangumaran, Subburaj; Borisch, Bettina; Hoessli, Daniel 1999
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Loss of expression of the beta subunit of soluble guanylyl cyclase prevents nitric oxide-mediated inhibition of DNA synthesis in smooth muscle cells of old rats Chen, L.; Daum, G.; Fischer, J. W.; Hawkins, S.; ... Clowes, A. W. 2000
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A poly(ortho ester) designed for combined ocular delivery of dexamethasone sodium phosphate and 5-fluorouracil: subconjunctival tolerance and in vitro release Zignani, M.; Einmahl, S.; Baeyens, V.; Varesio, Emmanuel; ... Gurny, Robert 2000
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In vitro assessment of new embolic liquids prepared from preformed polymers and water-miscible solvents for aneurysm treatment Mottu Del Rizzo, Florence; Gailloud, Philippe Edmond; Massuelle, Danielle; Rüfenacht, D.A.; Doelker, Eric 2000
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Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS Terrado, J.; Monnier, D.; Perrelet, D.; Vesin, Dominique; ... Garcia, Irène 2000
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Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo Alberti, Ingo; Kalia, Yogeshvar; Naik, Aarti; Bonny, J; Guy, Richard H. 2001
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Enhanced skin permeation of a lipophilic drug using supersaturated formulations Moser, Katrin; Kriwet, K; Kalia, Yogeshvar; Guy, Richard H. 2001
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Toxoplasma gondii myosins B/C: one gene, two tails, two localizations, and a role in parasite division Delbac, F; Sänger, A; Neuhaus, E M; Stratmann, R; ... Soldati-Favre, Dominique 2001
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Generalization of ionic partition diagrams to lipophilic compounds and to biphasic systems with variable phase volume ratios Gobry, V.; Ulmeanu, S. M.; Reymond, F.; Bouchard, Géraldine; ... Girault, H. H. 2001
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GnRH antagonists: a new generation of long acting analogues incorporating p-ureido-phenylalanines at positions 5 and 6 Jiang, G; Stalewski, J; Galyean, R; Dykert, J; ... Rivier, J E 2001
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Lipophilicity and solvation of anionic drugs Bouchard, Géraldine; Carrupt, Pierre-Alain; Testa, Bernard; Gobry, V.; Girault, H. H. 2002
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Effects of sucrose oleate and sucrose laureate on in vivo human stratum corneum permeability Ayala-Bravo, Hilda A; Quintanar Guerrero, David; Naik, Aarti; Kalia, Yogeshvar; ... Ganem Quintanar, Adriana 2003
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Imidazole H3-antagonists: relationship between structure and ex vivo binding to rat brain H3-receptors Vacondio, F.; Mor, M.; Silva, C.; Zuliani, V.; ... Testa, Bernard 2004
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Enhancement of topical delivery from biodegradable nanoparticles Alvarez Roman, Rocio; Naik, Aarti; Kalia, Yogeshvar; Guy, Richard H.; Fessi, Hatem 2004
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Novel RPLC stationary phases for lipophilicity measurement: solvatochromic analysis of retention mechanisms for neutral and basic compounds Stella, Cinzia; Galland, Alexandra; Liu, Xiangli; Testa, Bernard; ... Carrupt, Pierre-Alain 2005
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Skin permeation enhancement by sucrose esters: a pH-dependent phenomenon Cazares Delgadillo, Jennyfer; Naik, Aarti; Kalia, Yogeshvar; Quintanar-Guerrero, D.; Ganem-Quintanar, A. 2005
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A water-soluble prodrug of cyclosporine A for ocular application: A stability study Lallemand, Frédéric; Perrottet, Philippe; Felt-Baeyens, Olivia; Kloeti, Werner; ... Gurny, Robert 2005
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Circulating, soluble forms of major histocompatability complex antigens are not exosome-associated MacKay, P. A.; Leibundgut-Landmann, Salomé; Koch, Norbert; Dunn, A. C.; ... McLellan, A. D. 2006
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Biological conversion of a water-soluble prodrug of cyclosporine A Lallemand, Frédéric; Varesio, Emmanuel; Felt-Baeyens, O.; Bossy, Leila; ... Gurny, Robert 2007
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Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model Laurent, Alexandre; Mottu, Henry; Chapot, René; Zhang, Jong Qi; ... Merland, Jean-Jacques 2007
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Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus Collaud, Stéphane; Warloe, T.; Jordan, Olivier; Gurny, Robert; Lange, Norbert 2007
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Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl Diaz del Consuelo, Isabel; Falson, Françoise; Guy, Richard H.; Jacques, Yves 2007
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Hydrophilic Anchors for Transmembrane Anion-π Slides Gorteau, Virginie; Julliard, Marc D.; Matile, Stefan 2008
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Assessment of tailor-made HPMC-based matrix minitablets comprising a weakly basic drug compound Siepe, Stefanie; Lueckel, Barbara; Kramer, Andrea; Ries, Angelika; Gurny, Robert 2008
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High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media Bard, Bruno; Martel, Sophie; Carrupt, Pierre-Alain 2008
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The PAMPA technique as a HTS tool for partition coefficients determination in different solvent/water systems Ottaviani, Giorgio; Martel, Sophie; Escarala, Caroline; Nicolle, Edwige; Carrupt, Pierre-Alain 2008
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Dimethylfumarate reduces leukocyte rolling in vivo through modulation of adhesion molecule expression Rubant, Simone A.; Ludwig, Ralf J.; Diehl, Sandra; Hardt, Katja; ... Boehncke, Wolf-Henning 2008
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