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 TitleAuthors / EditorsDate
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Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell Maechler, Pierre; Kennedy, Eleanor; Wang, Haiyan; Wollheim, Claes 1998
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Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line Wang, Haiyan; Maechler, Pierre; Hagenfeldt-Johansson, Kerstin Arlette; Wollheim, Claes 1998
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Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell Maechler, Pierre; Wollheim, Claes 1998
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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis Maechler, Pierre; Wollheim, Claes 1999
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Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells Maechler, Pierre; Jornot, L; Wollheim, Claes 1999
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Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger Jornot, L; Maechler, Pierre; Wollheim, Claes; Junod, A F 1999
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Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell Maechler, Pierre; Wollheim, Claes 2000
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Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells Maechler, Pierre; Antinozzi, Peter; Wollheim, Claes 2000
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Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion Wang, Haiyan; Maechler, Pierre; Antinozzi, Peter; Hagenfeldt-Johansson, Kerstin Arlette; Wollheim, Claes 2000
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Mitochondrial calcium oscillations in C2C12 myotubes Challet, C; Maechler, Pierre; Wollheim, Claes; Ruegg, Urs 2001
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Mitochondrial function in normal and diabetic beta-cells Maechler, Pierre; Wollheim, Claes 2001
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Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation Wang, Haiyan; Maechler, Pierre; Ritz-Laser, B; Hagenfeldt-Johansson, Kerstin Arlette; ... Wollheim, Claes 2001
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GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells Rubi, Blanca; Ishihara, Hisamitsu; Hegardt, F G; Wollheim, Claes; Maechler, Pierre 2001
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Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state Pitter, J G; Maechler, Pierre; Wollheim, Claes; Spät, A 2002
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Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites Wollheim, Claes; Maechler, Pierre 2002
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Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells Ishihara, Hisamitsu; Maechler, Pierre; Gjinovci, Asllan; Herrera, Pedro Luis; Wollheim, Claes 2003
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Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Merglen, Arnaud; Theander, Sten; Rubi, Blanca; Chaffard, Gaelle; ... Maechler, Pierre 2004
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Tissue specificity of mitochondrial glutamate pathways and the control of metabolic homeostasis Frigerio, Francesca; Casimir, Marina Shamini; Carobbio, Stefania; Maechler, Pierre 2008
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The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress Li, Ning; Frigerio, Francesca; Maechler, Pierre 2008
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Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells Martin, David; Allagnat, F.; Chaffard, Gaelle; Caille, D.; ... Haefliger, J-A. 2008
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Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA Parone, Philippe; Da Cruz, Sandrine; Tondera, Daniel; Mattenberger, Yves Benoît; ... Martinou, Jean-Claude 2008
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Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction Li, Ning; Brun, Thierry; Cnop, Miriam; Cunha, Daniel A.; ... Maechler, Pierre 2009
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Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets Casimir, Marina Shamini; Rubi, Blanca; Frigerio, Francesca; Chaffard, Gaelle; Maechler, Pierre 2009
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Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism Bender, Katrin; Maechler, Pierre; McClenaghan, Neville H.; Flatt, Peter R.; Newsholme, Philip 2009
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Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia Vit, Jean-Philippe; Ohara, Peter T.; Sundberg, Christopher; Rubi, Blanca; ... Jasmin, Luc 2009
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Mitochondrial glutamate carrier GC1 as a newly identified player in the control of glucose-stimulated insulin secretion Casimir, Marina Shamini; Lasorsa, Francesco M.; Rubi, Blanca; Caille, Dorothée; ... Maechler, Pierre 2009
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Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis Carobbio, Stefania; Frigerio, Francesca; Rubi, Blanca; Vetterli, Laurene; ... Maechler, Pierre 2009
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PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction Ravnskjaer, Kim; Frigerio, Francesca; Boergesen, Michael; Nielsen, Tina; ... Mandrup, Susanne 2010
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Minireview: new roles for peripheral dopamine on metabolic control and tumor growth: let's seek the balance Rubi, Blanca; Maechler, Pierre 2010
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Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells Hirabara, Sandro M.; Curi, Rui; Maechler, Pierre 2010
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Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on beta-cells by enhancing glucose-stimulated insulin secretion Makom Ndifossap, Ivonne Gisele; Frigerio, Francesca; Casimir, Marina Shamini; Ngueguim Tsofack, Florence; ... Maechler, Pierre 2010
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The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells de Leeuw van Weenen, J. E.; Parlevliet, E. T.; Maechler, Pierre; Havekes, L. M.; ... Guigas, B. 2010
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Role of mitochondria in beta-cell function and dysfunction Maechler, Pierre; Li, Ning; Casimir, Marina Shamini; Vetterli, Laurene Marine; ... Brun, Thierry 2010
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Ataxia telangiectasia mutated (ATM) inhibition transforms human mammary gland epithelial cells Mandriota, Stefano Jacopo; Buser, Raphaele; Lesne, Laurence; Stouder, Christelle; ... Sappino, Pascal 2010
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Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism Frigerio, Francesca; Brun, Thierry; Bartley, C.; Usardi, A.; ... Maechler, Pierre 2010
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ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells Boergesen, Michael; Poulsen, Lars la Cour; Schmidt, Søren Fisker; Frigerio, Francesca; ... Mandrup, Susanne 2011
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Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis Vetterli, Laurene Marine; Maechler, Pierre 2011
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From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis Karaca Emre, Melis; Frigerio, Francesca; Maechler, Pierre 2011
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Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells Račková, Lucia; Cumaoğlu, Ahmet; Bağrıacık, E Umit; Štefek, Milan; ... Karasu, Çimen 2011
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Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats Auer, Veronika J; Bucher, Julian; Schremmer-Danninger, Elisabeth; Paulmurugan, Ramasamy; ... Berger, Frank 2011
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Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells Cumaoğlu, Ahmet; Rackova, Lucia; Stefek, Milan; Kartal, Murat; ... Karasu, Cimen 2011
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A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes Casimir, Marina Shamini; de Andrade, Paula B; Gjinovci, Asllan; Montani, Jean-Pierre; ... Dulloo, Abdul G 2011
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Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism Vetterli, Laurene Marine; Brun, Thierry; Giovannoni, Laurianne; Bosco, Domenico; Maechler, Pierre 2011
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Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role? Li, Ning; Stojanovski, Suzana; Maechler, Pierre 2012
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Mitochondria in endocrinology Maechler, Pierre 2012
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Mitochondrial signal transduction in pancreatic β-cells Maechler, Pierre 2012
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Procyanidins modify insulinemia by affecting insulin production and degradation Castell-Auví, Anna; Cedó, Lídia; Pallarès, Victor; Blay, M Teresa; ... Ardévol, Anna 2012
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Mitochondrial dysfunction in pancreatic β cells Supale, Sachin; Li, Ning; Brun, Thierry; Maechler, Pierre 2012
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Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase Vetterli, Laurene Marine; Carobbio, Stefania; Pournourmohammadi, Shirin; Martin-Del-Rio, Rafael; ... Maechler, Pierre 2012
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Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission Frigerio, Francesca Alda; Karaca Emre, Melis; De Roo, Mathias; Mlynárik, Vladimír; ... Maechler, Pierre 2012
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