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Calcium-induced insulin release in monolayer culture of the endocrine pancreas. Studies with ionophore A23187 Wollheim, Claes; Blondel, B; Trueheart, P A; Renold, A E; Sharp, G W 1975
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In vitro and in vivo studies on glucagonoma tissue Berger, M.; Teuscher, A.; Halban, Philippe A.; Trimble, E.; ... Muller, W. A. 1980
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Proinsulin modified by analogues of arginine and lysine is degraded rapidly in pancreatic B-cells Halban, Philippe A.; Amherdt, M.; Orci, Lelio; Renold, A. E. 1984
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Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets Halban, Philippe A.; Powers, S. L.; George, K. L.; Bonner-Weir, S. 1987
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Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II Sizonenko, S. V.; Halban, Philippe A. 1991
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Kinetics of proinsulin conversion in human islets Sizonenko, Stéphane; Irminger, J. C.; Buehler, Leo Hans; Deng, Shaoping; ... Halban, Philippe A. 1993
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TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes Sanvito, F.; Nichols, A.; Herrera, Pedro Luis; Huarte, Joachim; ... Orci, Lelio 1995
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Second-messenger regulation of receptor association with clathrin-coated pits: a novel and selective mechanism in the control of CD4 endocytosis Foti, Michelangelo; Carpentier, Jean-Louis; Aiken, C.; Trono, Didier; ... Krause, Karl-Heinz 1997
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Insulin resistance in HIV protease inhibitor-associated diabetes Yarasheski, K. E.; Tebas, P.; Sigmund, C.; Dagogo-Jack, S.; ... Powderly, W. G. 1999
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Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell Maechler, Pierre; Wollheim, Claes 2000
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Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice Hagenfeldt-Johansson, K. A.; Herrera, Pedro Luis; Wang, Haiyan; Gjinovci, A.; ... Wollheim, Claes 2001
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Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis Gut, A; Kiraly-Borri, Catherine Eva; Fukuda, M; Mikoshiba, K; ... Lang, Jochen 2001
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An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events Hamer, Isabelle; Foti, Michelangelo; Emkey, R; Cordier-Bussat, M; ... Carpentier, J-L 2002
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Mutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway Halban, Philippe A.; Irminger, Jean-Claude 2003
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Insulin-secreting beta-cell dysfunction induced by human lipoproteins Roehrich, Marc-Estienne Maurice; Mooser, Vincent; Lenain, Vincent; Herz, Joachim; ... Waeber, Gérard 2003
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Sorting ourselves out: seeking consensus on trafficking in the beta-cell Arvan, Peter; Halban, Philippe A. 2004
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Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets Iezzi-Bakhtiari, Mariella; Eliasson, Lena; Fukuda, Mitsunori; Wollheim, Claes 2005
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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling Knight, Zachary A; Gonzalez, Beatriz; Feldman, Morri E; Zunder, Eli R; ... Shokat, Kevan M 2006
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Biochemical quantification of total brain glycogen concentration in rats under different glycemic states Morgenthaler, Florence; Koski, Dee M; Kraftsik, Rudolf; Henry, Pierre-Gilles; Gruetter, Rolf 2006
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Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation Mathe, Zoltan; Dupraz, Philippe Victor Leon; Rinsch, Chris; Thorens, Bernard; ... Pepper, Michael Sean 2006
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Insulin-induced vascular endothelial growth factor expression is mediated by the NADPH oxidase NOX3 Carnesecchi, Stéphanie; Carpentier, Jean-Louis; Foti, Michelangelo; Szanto, Ildiko 2006
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The neck of caveolae is a distinct plasma membrane subdomain that concentrates insulin receptors in 3T3-L1 adipocytes Foti, Michelangelo; Porcheron, Geneviève; Fournier, Margot; Maeder Garavaglia, Christine; Carpentier, Jean-Louis 2007
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Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation Mouche, Sarah; Mkaddem, Sanae Ben; Wang, Wei; Katic, Masa; ... Szanto, Ildiko 2007
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TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis Qian, Bo; Wang, Haiyan; Men, Xiuli; Zhang, Wenjian; ... Lou, Jinning 2008
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Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C Bernsmeier, Christine; Duong, Francois H T.; Christen, Verena; Pugnale, Paolo; ... Heim, Markus H. 2008
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Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development Baertschiger, Reto Marc; Bosco, Domenico; Morel, Philippe; Serre-Beinier, Veronique; ... Gonelle-Gispert, Carmen 2008
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PTEN at the crossroad of metabolic diseases and cancer in the liver Vinciguerra, Manlio; Foti, Michelangelo 2008
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Permeation enhancer effect of chitosan and chitosan derivatives: comparison of formulations as soluble polymers and nanoparticulate systems on insulin absorption in Caco-2 cells Sadeghi, A M M; Dorkoosh, F A; Avadi, M R; Weinhold, M; ... Junginger, H E 2008
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Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis Gauthier, Benoît; Duhamel, Dominique L.; Iezzi, Mariella; Theander, Sten; ... Wollheim, Claes 2008
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Synaptotagmins bind calcium to release insulin Gauthier, Benoît; Wollheim, Claes 2008
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Munc 18-1 and granuphilin collaborate during insulin granule exocytosis Tomas Catala, Alejandra Del Don; Meda, Paolo; Regazzi, Romano; Pessin, Jeffrey E.; Halban, Philippe A. 2008
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Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats Merani, Shaheed; Pawlick, Rena L.; Edgar, Ryan L.; Toso, Christian; ... Shapiro, A M James 2009
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Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation Wiederkehr, Andreas; Park, Kyu-Sang; Dupont, Olivier; Demaurex, Nicolas; ... Wollheim, Claes 2009
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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 Feldman, Morris E; Apsel, Beth; Lempiainen, Aino; Loewith, Robbie Joséph; ... Shokat, Kevan M 2009
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Glucotoxicity and pancreatic proteomics Brunner, Yannick; Schvartz, Domitille; Priego Capote, Feliciano; Coute, Yohann; Sanchez, Jean-Charles 2009
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Ready, set, internalize: mechanisms and regulation of GLUT4 endocytosis Antonescu, Costin N.; Foti, Michelangelo; Sauvonnet, Nathalie; Klip, Amira 2009
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Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1 Galetti, Sandrine; Sarre, Alexandre; Perreten, Hélène; Produit-Zengaffinen, Nathalie; ... Assimacopoulos, Françoise 2009
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AEB-071 has minimal impact on onset of autoimmune diabetes in NOD mice Merani, S.; Edgar, R. L.; Toso, Christian; Emamaullee, J.; ... Shapiro, A M. J. 2009
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Modeling intrauterine growth retardation in rodents: Impact on pancreas development and glucose homeostasis Schwitzgebel Luscher, Valérie; Somm, Emmanuel; Klee, Philippe 2009
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Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice Cantley, James; Selman, Colin; Shukla, Deepa; Abramov, A. Y.; ... Withers, D. J. 2009
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Hepatitis C virus and type 2 diabetes Negro, Francesco; Alaei, Mahnaz 2009
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Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in culture Toso, Christian; McCall, Michael; Emamaullee, Juliet; Merani, Shaheed; ... Shapiro, A M James 2010
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Evidence against a direct role of klotho in insulin resistance Lorenzi, Olivier; Veyrat-Durebex, Christelle; Wollheim, Claes; Villemin, Pascal; ... Vischer, Ulrich Max 2010
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Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development Lu, Jieli; Herrera, Pedro Luis; Carreira, Christine; Bonnavion, Remy; ... Zhang, C. X. 2010
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Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance Lee, Hui-Young; Choi, Cheol Soo; Birkenfeld, Andreas L; Alves, Tiago C; ... Shulman, Gerald I 2010
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Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in mice Serre-Beinier, Veronique; Toso, Christian; Morel, Philippe; Gonelle-Gispert, Carmen; ... Berney, Thierry 2010
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Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands Virostko, John; Henske, Joseph; Vinet, Laurent; Lamprianou, Smaragda; ... Powers, Alvin C 2011
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Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis Vetterli, Laurene Marine; Maechler, Pierre 2011
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Focal adhesion remodeling is crucial for glucose-stimulated insulin secretion and involves activation of focal adhesion kinase and paxillin Rondas, Dieter; Tomas, Alejandra; Halban, Philippe A. 2011
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Connexin implication in the control of the murine beta-cell mass Klee, Philippe; Lamprianou, Smaragda; Charollais, Anne; Caille, Dorothée; ... Meda, Paolo 2011
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