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Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system Prinz, Marco; Schmidt, Hauke; Mildner, Alexander; Knobeloch, Klaus-Peter; ... Kalinke, Ulrich 2008
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Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo Klopfleisch, Steve; Merkler, Doron; Schmitz, Matthias; Kloppner, Sabine; ... Bruck, Wolfgang 2008
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Aggravation of viral hepatitis by platelet-derived serotonin Lang, Philipp A.; Contaldo, Claudio; Georgiev, Panco; El-Badry, Ashraf Mohammad; ... Lang, Karl S. 2008
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Propagation of spreading depression inversely correlates with cortical myelin content Merkler, Doron; Klinker, Florian; Jurgens, Tanja; Glaser, Raoul; ... Liebetanz, David 2009
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Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant Schmidt, Hauke; Raasch, Jenni; Merkler, Doron; Klinker, Florian; ... Prinz, Marco 2009
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Impaired antibody response causes persistence of prototypic T cell-contained virus Bergthaler, Andréas; Flatz, Lukas; Verschoor, Admar; Hegazy, Ahmed N.; ... Pinschewer, Daniel 2009
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T cells can mediate viral clearance from ependyma but not from brain parenchyma in a major histocompatibility class I- and perforin-independent manner Pinschewer, Daniel; Schedensack, Mariann; Bergthaler, Andréas; Horvath, Edit; ... Merkler, Doron 2010
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T cell-dependence of Lassa fever pathogenesis Flatz, Lukas; Rieger, Toni; Merkler, Doron; Bergthaler, Andréas; ... Pinschewer, Daniel 2010
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Oxidized ATP inhibits T-cell-mediated autoimmunity Lang, Philipp A.; Merkler, Doron; Funkner, Pauline; Shaabani, Namir; ... Lang, Karl S. 2010
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Targeted ablation of oligodendrocytes triggers axonal damage Ghosh, Aniket; Manrique-Hoyos, Natalia; Voigt, Aaron; Schulz, Jörg B; ... Simons, Mikael 2011
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Impact of sphingosine 1-phosphate modulation on immune outcomes Pinschewer, Daniel; Brinkmann, Volker; Merkler, Doron 2011
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A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis Nikić, Ivana; Merkler, Doron; Sorbara, Catherine; Brinkoetter, Mary; ... Kerschensteiner, Martin 2011
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IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system Merkler, Doron; Raasch, Jenni; Zeller, Nicolas; van Loo, Geert; ... Prinz, Marco 2011
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Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior Peruga, Isabella; Hartwig, Silvia; Merkler, Doron; Thöne, Jan; ... Linker, Ralf A 2012
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The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses Bonilla, Weldy V; Fröhlich, Anja; Senn, Karin; Kallert, Sandra; ... Pinschewer, Daniel 2012
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Late motor decline after accomplished remyelination: impact for progressive multiple sclerosis Manrique-Hoyos, Natalia; Grønborg, Mads; Kreutzfeldt, Mario; Schedensack, Mariann; ... Jürgens, Tanja 2012
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Focal immune-mediated white matter demyelination reveals an age-associated increase in axonal vulnerability and decreased remyelination efficiency Hampton, David W; Innes, Neill; Merkler, Doron; Zhao, Chao; ... Chandran, Siddharthan 2012
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Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia Scheffel, Jörg; Regen, Tommy; Van Rossum, Denise; Seifert, Stefanie; ... Hanisch, Uwe-Karsten 2012
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IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis Benkhoucha, Mahdia; Molnarfi, Nicolas; Santiago-Raber, Marie-Laure; Weber, Martin S; ... Lalive d'Epinay, Patrice 2012
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Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection Enouz, Sarah; Carrié, Lucie; Merkler, Doron; Bevan, Michael J; Zehn, Dietmar 2012
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TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis Schattling, Benjamin; Steinbach, Karin; Thies, Edda; Kruse, Martin; ... Friese, Manuel A 2012
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Neuroaxonal regeneration is more pronounced in early multiple sclerosis than in traumatic brain injury lesions Schirmer, Lucas; Merkler, Doron; König, Fatima B; Brück, Wolfgang; Stadelmann, Christine 2013
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Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis Serres, Sébastien; Bristow, Claire; de Pablos, Rocío M; Merkler, Doron; ... Anthony, Daniel C 2013
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Infection of type I interferon receptor-deficient mice with various old world arenaviruses: a model for studying virulence and host species barriers Rieger, Toni; Merkler, Doron; Günther, Stephan 2013
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Neuroprotective intervention by interferon-γ blockade prevents CD8+ T cell-mediated dendrite and synapse loss Kreutzfeldt, Mario; Bergthaler, Andréas; Fernandez, Marylise; Brück, Wolfgang; ... Merkler, Doron 2013
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Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature Daou, Samira; Ambrosioni Czyrko, Juan; Merkler, Doron; Calmy, Alexandra 2013
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TLR7 signaling exacerbates CNS autoimmunity through downregulation of Foxp3(+) Treg cells Lalive, PH; Benkhoucha, Mahdia; Tran, Ngoc Lan; Kreutzfeldt, Mario; ... Santiago-Raber, Marie-Laure 2014
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Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue Snaidero, Nicolas; Möbius, Wiebke; Czopka, Tim; Hekking, Liesbeth H.P.; ... Simons, Mikael 2014
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Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells Benkhoucha, Mahdia; Molnarfi, Nicolas; Dunand-Sauthier, Isabelle; Merkler, Doron; ... Lalive d'Epinay, Patrice 2014
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Pervasive Axonal Transport Deficits in Multiple Sclerosis Models Sorbara, Catherine Diamante; Wagner, Naomi Elizabeth; Ladwig, Anne; Nikić, Ivana; ... Kerschensteiner, Martin 2014
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Neuropathological Techniques to Investigate CNS Pathology in Experimental Autoimmune Encephalomyelitis (EAE) Steinbach, Karin; Merkler, Doron 2014
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Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination Rodriguez, Enrique Garea; Wegner, Christiane; Kreutzfeldt, Mario; Neid, Katharina; ... Merkler, Doron 2014
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Immunological mechanism of action and clinical profile of disease-modifying treatments in multiple sclerosis Du Pasquier, Renaud A.; Pinschewer, Daniel; Merkler, Doron 2014
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Oxysterols regulate encephalitogenic CD4+ T cell trafficking during central nervous system autoimmunity Chalmin, Fanny; Rochemont, Viviane; Lippens, Carla; Clottu, Aurélie Sarah; ... Pot, Caroline 2015
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain Goldmann, Tobias; Zeller, Nicolas; Raasch, Jenni; Kierdorf, Katrin; ... Prinz, Marco 2015
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Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage Bhattacharya, Anannya; Hegazy, Ahmed N; Deigendesch, Nikolaus; Kosack, Lindsay; ... Bergthaler, Andréas 2015
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IL-27 Induces Th17 Differentiation in the Absence of STAT1 Signaling Peters, Anneli; Fowler, Kevin D; Chalmin, Fanny; Merkler, Doron; ... Pot, Caroline 2015
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The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection Schliehe, Christopher; Flynn, Elizabeth K; Vilagos, Bojan; Richson, Udochuku; ... Bergthaler, Andréas 2015
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Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review Migliorini, Denis; Haller, Sven; Merkler, Doron; Pugliesi-Rinaldi, Angela; ... Dietrich, Pierre-Yves 2015
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B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation Bjarnadottir, Kristbjorg; Benkhoucha, Mahdia; Merkler, Doron; Weber, Martin S; ... Lalive d'Epinay, Patrice 2016
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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis Jürgens, Tanja; Jafari, Mehrnoosh; Kreutzfeldt, Mario; Bahn, Erik; ... Merkler, Doron 2016
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Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model Romanelli, Elisa; Merkler, Doron; Mezydlo, Aleksandra; Weil, Marie-Theres; ... Kerschensteiner, Martin 2016
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pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansion Ozga, Aleksandra J; Moalli, Federica; Abe, Jun; Swoger, Jim; ... Koritzinsky, Marianne 2016
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pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation Duraes, Fernanda V; Lippens, Carla; Steinbach, Karin; Dubrot Armendariz, Juan; ... Hugues, Stéphanie 2016
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In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology Herwerth, Marina; Kalluri, Sudhakar Reddy; Srivastava, Rajneesh; Kleele, Tatjana; ... Hemmer, Bernhard 2016
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TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cells Parsa, Roham; Lund, Harald; Tosevski, Ivana; Zhang, Xing-Mei; ... Harris, Robert A 2016
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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection Steinbach, Karin; Vincenti, Ilena; Kreutzfeldt, Mario; Page, Nicolas; ... Merkler, Doron 2016
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Interferon-driven deletion of antiviral B cells at the onset of chronic infection Fallet, Benedict; Narr, Kerstin; Ertuna, Yusuf I; Remy, Mélissa; ... Pinschewer, Daniel 2016
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Medulloblastoma in children and adults: one distinct disease entity? Von Bueren, André; Ares Molina, Carmen; Bartoli, Andréa; Fluss, Joel Victor; ... Ansari Djaberi, Marc Georges 2016
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Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell Responses Loi, Monica; Müller, Anne; Steinbach, Karin; Niven, Jennifer; ... Gannagé, Monique 2016
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