2022

Scientific Articles

unige:160140

On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm

Conod, Arwen; Silvano, Marianna; Ruiz Altaba, Ariel;

2020

Scientific Articles

unige:144923

Functional Pro-metastatic Heterogeneity Revealed by Spiked-scRNAseq Is Shaped by Cancer Cell Interactions and Restricted by VSIG1

Bernal Zamora, Carolina; Silvano, Marianna; Tapponnier, Yann; Anand, Santosh; ... Ruiz Altaba, Ariel

2019

Scientific Articles

unige:116909	Chimeric NANOG repressors inhibit glioblastoma growth in vivo in a context-dependent manner	Kuciak, Monika; Mas, Christophe; Borges Grazina, Ana Isabel; Sánchez-Gómez, Pilar; Ruiz Altaba, Ariel
unige:120328	Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer	Nowak-Sliwinska, Patrycja; Scapozza, Leonardo; Ruiz Altaba, Ariel;
unige:123163	The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases	Mishra, Sonakshi; Bernal Zamora, Carolina; Silvano, Marianna; Anand, Santosh; Ruiz Altaba, Ariel

Thesis supervisions

unige:130769

Mechanisms of pro-metastatic state induction

Conod, Arwen;

2017

Thesis supervisions

unige:94271

Functional dissection of TMED proteins in colon cancer metastasis

Mishra, Sonakshi;

2016

Scientific Articles

unige:77664	In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases	Singovski, Grigori; Bernal Zamora, Carolina; Kuciak, Monika; Siegl-Cachedenier, Irène; ... Ruiz Altaba, Ariel
unige:100251	Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells	Seth, Chandan; Mas, Christophe; Conod, Arwen; Mueller, Jens; ... Ruiz Altaba, Ariel
unige:85040	Metastases and Colon Cancer Tumor Growth Display Divergent Responses to Modulation of Canonical WNT Signaling	Seth, Chandan; Ruiz Altaba, Ariel;

2015

Thesis supervisions

unige:76754	Canonical WNT signaling in colon cancer growth and metastasis	Seth, Chandan;
unige:80568	The study of the pro-metastatic reprogramming of human primary colon cancer cells in vitro and in vivo	Singovski, Grigori;

2014

Scientific Articles

unige:39902	A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12	Duquet, Arnaud; Melotti, Alice; Mishra, Sonakshi; Malerba, Monica; ... Ruiz Altaba, Ariel
unige:44199	Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy	Aberger, Fritz; Ruiz Altaba, Ariel;
unige:44224	The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer	Melotti, Alice; Mas, Christophe; Kuciak, Monika; Lorente Trigos, Aiala; ... Ruiz Altaba, Ariel

2013

Scientific Articles

unige:32345	Morphogenetic action through flux-limited spreading	Verbeni, M; Sánchez, O; Mollica, E; Siegl-Cachedenier, Irène; ... Soler, J
unige:43406	On flux-limited morphogenesis	Verbeni, M.; Sánchez, O.; Mollica, E.; Siegl-Cachedenier, Irène; ... Soler, J.

2011

Scientific Articles

unige:30426

Hedgehog signaling and the Gli code in stem cells, cancer, and metastases

Ruiz Altaba, Ariel;

2010

Scientific Articles

unige:21092	BMP signaling promotes the growth of primary human colon carcinomas in vivo	Lorente-Trigos, Aiala; Varnat, Frédéric; Melotti, Alice; Ruiz Altaba, Ariel;
unige:9042	Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals	Stecca, Barbara; Ruiz Altaba, Ariel;
unige:9065	Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling	Varnat, Frédéric; Zacchetti, Giovanna; Ruiz Altaba, Ariel;
unige:21368	Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas	Varnat, Frédéric; Siegl-Cachedenier, Irène; Malerba, Monica; Gervaz, Pascal; Ruiz Altaba, Ariel
unige:21402	NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53	Zbinden, Marie; Duquet, Arnaud; Lorente-Trigos, Aiala; Ngwabyt, Sandra-Nadia; ... Ruiz Altaba, Ariel
unige:21120	Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations	Mas, Christophe; Ruiz Altaba, Ariel;

2009

Scientific Articles

unige:9041	A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers	Stecca, Barbara; Ruiz Altaba, Ariel;
unige:9007	Entity versus property: tracking the nature, genesis and role of stem cells in cancer. Conference on Stem cells and cancer	Ruiz Altaba, Ariel; Brand, A. H.;
unige:9064	Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion	Varnat, Frédéric; Duquet, Arnaud; Malerba, Monica; Zbinden, Marie; ... Ruiz Altaba, Ariel

Thesis supervisions

unige:6442

Interactions between Homeodomain proteins and Shh-Gli pathway in brain tumors and the stem cells

Zbinden, Marie;

2008

Scientific Articles

unige:9163	Regulation of survival in adult hippocampal and glioblastoma stem cell lineages by the homeodomain-only protein HOP	De Toni, Arianna; Zbinden, Marie; Epstein, J. A.; Ruiz Altaba, Ariel; ... Caille, Isabelle
unige:1430	Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?	Ruiz Altaba, Ariel;

2007

Scientific Articles

unige:9157	HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity	Clement, Virginie; Sanchez, Pilar; De Tribolet, Nicolas; Radovanovic, Ivan; Ruiz Altaba, Ariel
unige:9038	Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways	Stecca, Barbara; Mas, Christophe; Clement, Virginie; Zbinden, Marie; ... Ruiz Altaba, Ariel
unige:9254	The Gli code: an information nexus regulating cell fate, stemness and cancer	Ruiz Altaba, Ariel; Mas, Christophe; Stecca, Barbara;

2005

Scientific Articles

unige:9040	Brain as a paradigm of organ growth: Hedgehog-Gli signaling in neural stem cells and brain tumors	Stecca, Barbara; Ruiz Altaba, Ariel;
unige:9228	Cooperative requirement of the Gli proteins in neurogenesis	Nguyen, Van; Chokas, A. L.; Stecca, Barbara; Ruiz Altaba, Ariel;
unige:9013	In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice	Sanchez, Pilar; Ruiz Altaba, Ariel;
unige:9039	Interference with HH-GLI signaling inhibits prostate cancer	Stecca, Barbara; Mas, Christophe; Ruiz Altaba, Ariel;
unige:9237	Sonic hedgehog controls stem cell behavior in the postnatal and adult brain	Palma, Veronica; Lim, D. A.; Dahmane, Nadia; Sanchez, Pilar; ... Ruiz Altaba, Ariel
unige:9011	Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer	Sanchez, Pilar; Clement, Virginie; Ruiz Altaba, Ariel;

2004

Scientific Articles

unige:154162	Hedgehog--Gli signaling in brain tumors: stem cells and paradevelopmental programs in cancer	Ruiz Altaba, Ariel; Stecca, Barbara Ada; Sanchez, Pilar;
unige:8949	Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex	Palma, Veronica; Ruiz Altaba, Ariel;
unige:9012	Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling	Sanchez, Pilar; Hernandez, A. M.; Stecca, Barbara; Kahler, A. J.; ... Ruiz Altaba, Ariel

2003

Scientific Articles

unige:154165	Development. Longing for ligand: hedgehog, patched, and cell death	Guerrero, Isabelle; Ruiz Altaba, Ariel;
unige:154163	Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features	Roessler, Erich; Du, Yang-Zhu; Mullor, Jose L; Casas, Esther; ... Muenke, Maximilian
unige:154164	The emergent design of the neural tube: prepattern, SHH morphogen and GLI code	Ruiz Altaba, Ariel; Nguyên, Vân; Palma, Veronica;

2002

Scientific Articles

unige:154166	A gene expression map of human chromosome 21 orthologues in the mouse	Gitton, Yorick; Dahmane, Nadia; Baik, Sonya; Ruiz Altaba, Ariel; ... Yaspo, Marie-Laure
unige:154168	Gli and hedgehog in cancer: tumours, embryos and stem cells	Ruiz Altaba, Ariel; Sánchez, Pilar; Dahmane, Nadia;
unige:154170	Growth, hedgehog and the price of GAS.	Mullor, José L; Ruiz Altaba, Ariel;
unige:154169	Hedgehog-Gli signalling and the growth of the brain	Ruiz Altaba, Ariel; Palma, Verónica; Dahmane, Nadia;
unige:154167	Pathways and consequences: Hedgehog signaling in human disease	Mullor, José L; Sánchez, Pilar; Ruiz Altaba, Ariel;