Merkler, Doron

 
 
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2020

Scientific Articles

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Chronic viral infection promotes efficient germinal center B cell responsesFallet, Bénédict; Hao, Yi; Florova, Marianna; Cornille, Karen; ... Pinschewer, Daniel D
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Microglial A20 protects the brain from CD8 T-cell-mediated immunopathologyMohebiany, Alma Nazlie; Ramphal, Nishada Shakunty; Karram, Khalad; Di Liberto, Giovanni; ... Waisman, Ari

2019

Scientific Articles

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Bassoon proteinopathy drives neurodegeneration in multiple sclerosisSchattling, Benjamin; Engler, Jan Broder; Volkmann, Constantin; Rothammer, Nicola; ... Friese, Manuel A
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Brain-resident memory T cells generated early in life predispose to autoimmune disease in miceSteinbach, Karin; Vincenti, Ilena; Egervari, Kristof Levente; Kreutzfeldt, Mario; ... Merkler, Doron
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CD8+ T cells induce cachexia during chronic viral infectionBaazim, Hatoon; Schweiger, Martina; Moschinger, Michael; Xu, Haifeng; ... Bergthaler, Andreas
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Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversityFecher, Caroline; Trovò, Laura; Müller, Stephan A; Snaidero, Nicolas; ... Misgeld, Thomas
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Dendritic cell accumulation in the gut and central nervous system is differentially dependent on α4 integrinsSie, Christopher; Perez, Laura Garcia; Kreutzfeldt, Mario; Potthast, Maria; ... Korn, Thomas
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Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cellsPage, Nicolas; Klimek, Bogna; De Roo, Mathias; Steinbach, Karin; ... Merkler, Doron
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Fulminant multifocal relapse in a fingolimod-treated multiple sclerosis patientBreville, Gauthier; Lascano, Agustina Maria; Merkler, Doron; Roth, Serge; Lalive d'Epinay, Patrice
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In vivo function of the lipid raft protein flotillin-1 during CD8+ T cell-mediated host surveillanceFicht, Xenia; Ruef, Nora; Stolp, Bettina; Samson, Guerric P B; ... Stein, Jens V
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Initial viral inoculum determines kinapse-and synapse-like T cell motility in reactive lymph nodesSivapatham, Sujana; Ficht, Xenia; Barreto de Albuquerque, Juliana; Page, Nicolas; ... Stein, Jens V
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Melanocytic colonization of choroid plexus papilloma: a previously undocumented source of pigment storage in the plexogenic epitheliumEgervari, Kristof Levente; Lobrinus, Johannes Alexander; Merkler, Doron; Vajtai, Istvan;
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Phase I/II trial testing safety and immunogenicity of the multipeptide IMA950/poly-ICLC vaccine in newly diagnosed adult malignant astrocytoma patientsMigliorini, Denis; Dutoit Vallotton, Valérie; Allard, Mathilde Camille; Grandjean Hallez, Nicole; ... Dietrich, Pierre-Yves
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TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infectionAlfei, Francesca; Kanev, Kristiyan; Hofmann, Maike; Wu, Ming; ... Zehn, Dietmar

Thesis supervisions

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In vivo RNA interference screening to explore T cell behaviour in neuroinflammationKlimek, Bogna;
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Synaptic stripping in CD8+ T cell mediated encephalitisDi Liberto, Giovanni;

2018

Scientific Articles

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Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case ReportEl-Ayadi, Moatasem; Egervari, Kristof Levente; Merkler, Doron; Mckee, Thomas Alexander; ... Von Bueren, André
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Enhanced Voluntary Exercise Improves Functional Recovery following Spinal Cord Injury by Impacting the Local Neuroglial Injury Response and Supporting the Rewiring of Supraspinal CircuitsLoy, Kristina; Schmalz, Anja; Hoche, Tobias; Jacobi, Anne; ... Bareyre, Florence M
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Expression of the DNA-binding factor TOX promotes the encephalitogenic potential of microbe-induced autoreactive CD8+ T cellsPage, Nicolas; Klimek, Bogna; De Roo, Mathias; Steinbach, Karin; ... Merkler, Doron
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Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic ImprovementsFabbiano, Salvatore; Suarez Zamorano, Nicolas; Chevalier, Claire; Lazarevic, Vladimir; ... Trajkovski, Mirko
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High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and DiseaseMrdjen, Dunja; Pavlovic, Anto; Hartmann, Felix J; Schreiner, Bettina; ... Becher, Burkhard
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Histone Deacetylases 1 and 2 Regulate Microglia Function during Development, Homeostasis, and Neurodegeneration in a Context-Dependent MannerDatta, Moumita; Staszewski, Ori; Raschi, Elena; Frosch, Maximilian; ... Prinz, Marco
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Myeloid-derived suppressor cells control B cell accumulation in the central nervous system during autoimmunityKnier, Benjamin; Hiltensperger, Michael; Sie, Christopher; Aly, Lilian; ... Korn, Thomas
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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic StrippingDi Liberto, Giovanni; Pantelyushin, Stanislav; Kreutzfeldt, Mario; Page, Nicolas; ... Merkler, Doron
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Resident-memory T cells in tissue-restricted immune responses: for better or worse?Steinbach, Karin; Vincenti, Ilena; Merkler, Doron;
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The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cellsMoalli, Federica; Ficht, Xenia; Germann, Philipp; Vladymyrov, Mykhailo; ... Stein, Jens V
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The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS researchSteinemann, Nina; Kuhle, Jens; Calabrese, Pasquale; Kesselring, Jürg; ... von Wyl, Viktor

Thesis supervisions

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Brain-resident memory CD8+ T cells: roles in protection and diseaseVincenti, Ilena;

2016

Scientific Articles

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B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammationBjarnadottir, Kristbjorg; Benkhoucha, Mahdia; Merkler, Doron; Weber, Martin S; ... Lalive d'Epinay, Patrice
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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infectionSteinbach, Karin; Vincenti, Ilena; Kreutzfeldt, Mario; Page, Nicolas; ... Merkler, Doron
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In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathologyHerwerth, Marina; Kalluri, Sudhakar Reddy; Srivastava, Rajneesh; Kleele, Tatjana; ... Hemmer, Bernhard
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Interferon-driven deletion of antiviral B cells at the onset of chronic infectionFallet, Benedict; Narr, Kerstin; Ertuna, Yusuf I; Remy, Mélissa; ... Pinschewer, Daniel
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Macroautophagy Proteins Control MHC Class I Levels on Dendritic Cells and Shape Anti-viral CD8(+) T Cell ResponsesLoi, Monica; Müller, Anne; Steinbach, Karin; Niven, Jennifer; ... Gannagé, Monique
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Medulloblastoma in children and adults: one distinct disease entity?Von Bueren, André; Ares Molina, Carmen; Bartoli, Andréa; Fluss, Joel Victor; ... Ansari Djaberi, Marc Georges
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Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal modelRomanelli, Elisa; Merkler, Doron; Mezydlo, Aleksandra; Weil, Marie-Theres; ... Kerschensteiner, Martin
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pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammationDuraes, Fernanda V; Lippens, Carla; Steinbach, Karin; Dubrot Armendariz, Juan; ... Hugues, Stéphanie
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pMHC affinity controls duration of CD8+ T cell-DC interactions and imprints timing of effector differentiation versus expansionOzga, Aleksandra J; Moalli, Federica; Abe, Jun; Swoger, Jim; ... Koritzinsky, Marianne
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Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosisJürgens, Tanja; Jafari, Mehrnoosh; Kreutzfeldt, Mario; Bahn, Erik; ... Merkler, Doron
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TGFβ regulates persistent neuroinflammation by controlling Th1 polarization and ROS production via monocyte-derived dendritic cellsParsa, Roham; Lund, Harald; Tosevski, Ivana; Zhang, Xing-Mei; ... Harris, Robert A

Thesis supervisions

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La nucléoprotéine est nécessaire à l'immunogénicité des vecteurs vaccinaux basés sur les virus de la chorioméningite lymphocytaire recombinants (rLCMV)Darbre, Stéphanie;
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