2021

Scientific Articles

unige:151171	From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation	Cecchini, Carlotta; Pannilunghi, Sara; Tardy, Sébastien; Scapozza, Leonardo;
unige:150499	Heat-stability study of various insulin types in tropical temperature conditions: new insights towards improving diabetes care	Kaufmann, Béatrice; Boulle, Philippa; Berthou, Flavien; Fournier, Margot; ... Scapozza, Leonardo

2020

Scientific Articles

unige:144944	Cooperative binding of the tandem WW domains of PLEKHA7 to PDZD11 promotes conformation-dependent interaction with tetraspanin 33	Rouaud, Florian; Tessaro, Francesca; Aimaretti, Laura; Scapozza, Leonardo; Citi, Sandra
unige:136484	Identification of anti-mycobacterium and anti-legionella compounds with potential distinctive structural scaffolds from an HD-PBL using phenotypic screens in amoebae host models	Hanna, Nabil; Kicka, Sébastien; Chiriano, Gianpaolo; Harrison, Christopher; ... Soldati, Thierry
unige:137056	Platelet Transforming Growth Factor-β1 Induces Liver Sinusoidal Endothelial Cells to Secrete Interleukin-6	Balaphas, Alexandre; Meyer, Jérémy; Perozzo, Remo; Zeisser-Labouebe, Magali; ... Buehler, Leo Hans

Thesis supervisions

unige:142252

Multiple Applications of Structure-based Methods in Drug Discovery

Tessaro, Francesca;

2019

Scientific Articles

unige:122901	DDR1 role in fibrosis and its pharmacological targeting	Moll, Solange; Desmoulière, Alexis; Moeller, Marcus J; Pache, Jean-Claude; ... Prunotto, Marco
unige:120328	Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer	Nowak-Sliwinska, Patrycja; Scapozza, Leonardo; Ruiz Altaba, Ariel;

2018

Scientific Articles

unige:103009	Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets	Trofimov, Valentin; Kicka, Sébastien; Mucaria, Sabrina; Hanna, Nabil; ... Soldati, Thierry
unige:106639	Autoregulation of Class II Alpha PI3K Activity by Its Lipid-Binding PX-C2 Domain Module	Wang, Haibin; Lo, Wen-Ting; Vujičić Žagar, Andreja; Gulluni, Federico; ... Vadas, Oscar
unige:103072	Modeling and resistant alleles explain the selectivity of antimalarial compound 49c towards apicomplexan aspartyl proteases	Mukherjee, Budhaditya; Tessaro, Francesca; Vahokoski, Juha; Kursula, Inari; ... Soldati-Favre, Dominique
unige:114092	Tamoxifen prolongs survival and alleviates symptoms in mice with fatal X-linked myotubular myopathy	Gayi, Elinam; Neff, Laurence Anne; Massana Muñoz, Xènia; Ismail, Hesham; ... Scapozza, Leonardo

Preprints

unige:112884

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

Kicka, Sébastien; Hanna, Nabil; Chiriano, Gianpaolo; Harrison, Christopher; ... Soldati, Thierry

Thesis supervisions

unige:105266	Development of new chemical and physical strategies to enhance topical drug delivery	Santer, Verena;
unige:110627	Identification and analysis of the putative AMP-activated protein kinase (AMPK) in blood stream form of Trypanosoma brucei	Ambuehl, Chiara;
unige:114118	Nanocarrier systems and iontophoresis: complementary approaches for targeted cutaneous delivery of hydrophobic and hydrophilic drugs	Kandekar, Somnath;

2017

Scientific Articles

unige:96991

Inhibitors of Mycobacterium marinum virulence identified in a Dictyostelium discoideum host model

Ouertatani, Hajer; Kicka, Sébastien; Chiriano, Gianpaolo; Harrison, Christopher F; ... Cosson, Pierre

2016

Scientific Articles

unige:83859

In silico driven design and synthesis of rhodanine derivatives as novel antibacterials targeting the enoyl reductase InhA

Slepikas, Liudas; Chiriano, Gianpaolo; Perozzo, Remo; Tardy, Sébastien; ... Scapozza, Leonardo

Thesis supervisions

unige:93953	A non-coding RNA network influenced by genetic polymorphism controls E-cadherin expression in human cancers	Pisignano, Giuseppina;
unige:94032	A novel oncogenic axis involving the ETS factor ESE3/EHF, miR-424, COP1 and STAT3 drives prostate tumor progression	Dallavalle, Cécilia;
unige:88262	EZH2 induces methylation of ERG enhancing its transcriptional and transforming activity	Curti, Laura;

2015

Scientific Articles

unige:55064	A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy	Kaderli, Sema Gwendolyn; Boulocher, C; Pillet, Eric François Alfred; Watrelot-Virieux, D; ... Jordan, Olivier
unige:82439	A subsetofN-substituted phenothiazines inhibits NADPH oxidases	Seredenin, Tamara; Chiriano, Gianpaolo; Filippova, Aleksandra; Nayernia, Zeynab; ... Jaquet, Vincent
unige:76665	Adrenergic antagonists restrict replication of Legionella	Harrison, Christopher F; Kicka, Sébastien; Kranjc Pietrucci, Agata; Finsel, Ivo; ... Hilbi, Hubert
unige:76776	Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophila	Harrison, Christopher F.; Chiriano, Gianpaolo; Finsel, Ivo; Manske, Christian; ... Hilbi, Hubert

Thesis supervisions

unige:55022	Modulating physicochemical properties of drugs to optimise topical delivery: novel prodrugs of aciclovir to improve its cutaneous and ocular bioavailability using iontophoresis or supersaturated formulations	Chen, Yong;
unige:80925	Novel strategies to optimize topical skin bioavailability of low and high molecular weight drugs	Lapteva, Maria;

2014

Scientific Articles

unige:80016	Diapocynin, a Dimer of the NADPH Oxidase Inhibitor Apocynin, Reduces ROS Production and Prevents Force Loss in Eccentrically Contracting Dystrophic Muscle	Ismail, Hesham; Scapozza, Leonardo; Ruegg, Urs; Dorchies, Olivier;
unige:35896	Differences in Conformational Dynamics between Plasmodium falciparum and Human Hsp90 Orthologues Enable the Structure-Based Discovery of Pathogen-Selective Inhibitors	Wang, Tai; Bisson, William Henry; Mäser, Pascal; Scapozza, Leonardo; Picard, Didier
unige:38876	Establishment and validation of whole-cell based fluorescence assays to identify anti-mycobacterial compounds using the Acanthamoeba castellanii-Mycobacterium marinum host-pathogen system	Kicka, Sébastien; Trofimov, Valentin; Harrison, Christopher; Ouertatani, Hajer; ... Soldati, Thierry

Thesis supervisions

unige:38424	A positive feedback loop between ESE1/ELF3 and NF-κB promotes prostate cancer progression	Longoni, Nicole;
unige:42122	Development of novel hyaluronic acid- based viscosupplementation formulations for osteoarthrosis	Kaderli, Sema Gwendolyn;
unige:39207	Recurrent 11q24.3 gain contributes to the pathogenesis of diffuse large B cell lymphoma by deregulating ETS1 and FLI1	Testoni, Monica;
unige:45872	Synthesis and biological evaluation of EGFR/HER-2 inhibitors: analogs of 5-substituted-4-anilinoquinazoline and 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile: screening for development of novel PET tracers	Pimple, Surekha;

2013

Scientific Articles

unige:33803

Synthesis and in vitro evaluation of a novel radioligand for αvβ3 integrin receptor imaging: [18F]FPPA-c(RGDfK)

Monaco, Alessandra; Zoete, Vincent; Alghisi, Gian Carlo; Rüegg, Curzio; ... Seimbille, Yann

Thesis supervisions

unige:29046	Cerebrospinal fluid biomarkers for stage determination and treatment outcome evaluation in patients affected by Human African trypanosomiasis	Tiberti, Natalia;
unige:30027	From compound to target: chemical proteomics and in silico screening for target identification in Plasmodium falciparum	Lauciello, Leonardo;
unige:40046	Genetic and chemical validation of Trypanosoma brucei adenosine kinase, the intracellular target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]-morpholine	Graven, Patricia;
unige:33246	Genomic profiling of Anaplastic Large Cell Lymphoma	Boi, Michela;
unige:28387	Intravitreal formulations targeting the retinal vasculature in posterior segment eye diseases	Veurink, Marieke;
unige:32133	Role of oxidative stress and calcium regulation in Duchenne muscular dystrophy: pharmacological investigations	Ismail, Hesham;
unige:146908	Skin delivery: Prodrug design & synthesis: Novel Cationic NSAIDs ester prodrugs for electrically assisted skin permeation-Iontophoresis	El Mahrab-Robert, Majdeline;
unige:41629	Synthesis of small molecules via click chemistry for positron emission tomography (PET) imaging of tumor integrin αvβ3 and/or α5β1 expression	Monaco, Alessandra;
unige:37048	Targeting STAT3 for cancer therapy: definition of mechanisms of action of direct STAT3 inhibitors	Brambilla, Lara;
unige:27730	Transgenic enrichment strategies for cardiac cells derived from mouse embryonic stem cells using HSV1-TK-ganciclovir and CD-5-fluorouracil	Heuking, Pernilla;

2012

Scientific Articles

unige:22841

The pharmaceutical biochemistry group: where pharmaceutical chemistry meets biology and drug delivery

Kalia, Yogeshvar; Perozzo, Remo; Scapozza, Leonardo;

Thesis supervisions

unige:29915

Transdermal iontophoresis for the controlled delivery of therapeutic agents to treat neurodegenerative diseases

Kalaria, Dhaval;

2011

Scientific Articles

unige:25563	NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action	Jaquet, Vincent; Marcoux, Julien; Forest, Eric; Leidal, Kevin; ... Bedard, Karen
unige:22837	Noninvasive transdermal iontophoretic delivery of biologically active human basic fibroblast growth factor	Dubey, Sachin Kumar; Perozzo, Remo; Scapozza, Leonardo; Kalia, Yogeshvar;

Thesis supervisions

unige:22912

Administration transdermique non-invasive par iontophorèse de protéines: démonstration de la faisabilité et de la compréhension du mécanisme d'électrotransport

Dubey, Sachin Kumar;