2021

Scientific Articles

unige:150115	Mesoporous Silica Nanoparticles as pH-Responsive Carrier for the Immune-Activating Drug Resiquimod Enhance the Local Immune Response in Mice	Wagner, Julia; Gößl, Dorothée; Ustyanovska, Natasha; Xiong, Mengyao; ... Bourquin, Carole
unige:149708	Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy	Darwich, Adam S; Polasek, Thomas M; Aronson, Jeffrey K; Ogungbenro, Kayode; ... Rostami-Hodjegan, Amin

2020

Scientific Articles

unige:149691	Bioavailability of Vortioxetine After a Roux-en-Y Gastric Bypass	Vandenberghe, Frederik; Gilet, Patricia; Daali, Youssef; Favre, Lucien Ody; Eap, Chin Bin
unige:144205	Comparing Dried Blood Spots and Plasma Concentrations for Busulfan Therapeutic Drug Monitoring in Children	Dilo, Ana; Daali, Youssef; Desmeules, Jules Alexandre; Chalandon, Yves; ... Ansari Djaberi, Marc Georges
unige:149437	Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients	Fontana, Pierre; Ibberson, Mark; Stevenson, Brian; Wigger, Leonore; ... Reny, Jean-Luc
unige:149715	Deep proteomics and phosphoproteomics reveal novel biological pathways perturbed by morphine, morphine-3-glucuronide and morphine-6-glucuronide in human astrocytes	Dozio, Vito; Daali, Youssef; Desmeules, Jules Alexandre; Sanchez, Jean-Charles;
unige:149706	Evaluation of Phenotypic and Genotypic Variations of Drug Metabolising Enzymes and Transporters in Chronic Pain Patients Facing Adverse Drug Reactions or Non-Response to Analgesics: A Retrospective Study	Rollason, Victoria; Lloret-linaret, Célia; Ing Lorenzini, Kuntheavy; Daali, Youssef; ... Desmeules, Jules Alexandre
unige:149695	GABAergic modulation of secondary hyperalgesia: A randomized controlled 4-way crossover trial with the α2-subunit preferring GABA positive allosteric modulator, N-desmethyl-clobazam in healthy volunteers	Matthey, Alain; Daali, Youssef; Curtin, François; Poncet, Antoine; ... Besson, Marie
unige:149068	Impact of acute inflammation on cytochromes P450 activity assessed by the Geneva Cocktail	Lenoir, Camille; Daali, Youssef; Rollason, Victoria; Curtin, François; ... Samer, Caroline Flora
unige:149438	Impact of enantiomer-specific changes in pharmacokinetics between infants and adults on the target concentration of racemic ketorolac: A pooled analysis	Cloesmeijer, Michael E; van Esdonk, Michiel J; Lynn, Anne M; Smits, Anne Claudine Catherine; ... Mian, Paola
unige:149433	Mixing Drugs and Genetics: A Complex Hemorrhagic Cocktail	Barbolini, Laura; Terrier, Jean; Marti, Christophe; Samer, Caroline Flora; ... Reny, Jean-Luc
unige:149439	Modern approaches for the phenotyping of cytochrome P450 enzymes in children	Magliocco, Gaëlle; Daali, Youssef;
unige:142854	Optimized low‐dose combinatorial drug treatment boosts selectivity and efficacy of colorectal carcinoma treatment	Zoetemelk, Marloes; Ramzy, George Mourad; Rausch, Magdalena; Kossler, Thibaud; ... Nowak-Sliwinska, Patrycja
unige:141697	Safety of the Geneva Cocktail, a Cytochrome P450 and P-Glycoprotein Phenotyping Cocktail, in Healthy Volunteers from Three Different Geographic Origins	Rollason, Victoria; Mouterde, Médéric; Daali, Youssef; Čížková, Martina; ... Desmeules, Jules Alexandre

2019

Scientific Articles

unige:121734	CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver content	Lloret-Linares, Célia; Daali, Youssef; Abbara, Chadi; Carette, Claire; ... Declèves, Xavier
unige:128196	Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins	Samer, Caroline Flora; Gloor, Yvonne Sylvia; Rollason Gumprecht, Victoria; Guessous, Idris; ... Daali, Youssef
unige:126980	Drug-induced expression of the RNA-binding protein HuR attenuates the adaptive response to BRAF inhibition in melanoma	Merat, Rastine; Bugi, Aurore; Wrobel, Ludovic; Py, Céline; ... Liaudet, Nicolas
unige:128192	Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail	Bosilkovska Weisskopf, Marija; Magliocco, Gaëlle; Desmeules, Jules Alexandre; Samer, Caroline Flora; Daali, Youssef
unige:134650	Liquid Chromatography-Tandem Mass Spectrometry Method for Ticagrelor and its Active Metabolite Determination in Human Plasma: Application to a Pharmacokinetic Study	Marsousi, Niloufar; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef;
unige:127240	Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled study	Czarnetzki, Christoph; Desmeules, Jules Alexandre; Tessitore, Enrico; Faundez, Antonio; ... Tramer, Martin
unige:121245	Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approaches	Magliocco, Gaëlle; Thomas, Aurélien; Desmeules, Jules Alexandre; Daali, Youssef;
unige:121056	Physiologically-based pharmacokinetic modeling for the prediction of CYP2D6-mediated gene-drug-drug interactions	Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
unige:127237	Preclinical Evaluation of Safety of Fucoidan Extracts From Undaria pinnatifida and Fucus vesiculosus for Use in Cancer Treatment	Bovet, Luc; Samer, Caroline Flora; Daali, Youssef;
unige:128193	Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling	Magliocco, Gaëlle; Rodieux, Frédérique; Desmeules, Jules Alexandre; Samer, Caroline Flora; Daali, Youssef
unige:121072	Towards personalized antithrombotic treatments: focus on P2Y12 inhibitors and direct oral anticoagulants	Terrier, Jean; Daali, Youssef; Fontana, Pierre; Csajka, Chantal; Reny, Jean-Luc
unige:119613	Variables of interest to predict glomerular filtration rate in preterm newborns in the first days of life	Wilhelm-Bals, Alexandra Marina; Combescure, Christophe; Chehade, Hassib; Daali, Youssef; Parvex, Paloma Maria

Thesis supervisions

unige:121673

Proteomic phenotyping of CNS cells exposed to inflammatory stimuli and opioids

Dozio, Vito;

2018

Scientific Articles

unige:110999	Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives	Storelli, Flavia; Samer, Caroline Flora; Reny, Jean-Luc; Desmeules, Jules Alexandre; Daali, Youssef
unige:110974	Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes	Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
unige:111012	Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites	Marsousi, Niloufar; Daali, Youssef; Fontana, Pierre; Reny, Jean-Luc; ... Samer, Caroline Flora
unige:115534	Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting	Lloret-Linares, Célia; Bosilkovska Weisskopf, Marija; Daali, Youssef; Gex-Fabry, Marianne; ... Besson, Marie
unige:98710	Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
unige:110991	Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report	Aebischer, Gaspard; Ing Lorenzini, Kuntheavy; Tomala, Simon; Desmeules, Jules Alexandre; ... Samer, Caroline Flora
unige:111766	Therapeutic Drug Monitoring of Busulfan for the Management of Pediatric Patients: Cross-Validation of Methods and Long-Term Performance	Choong, Eva; Uppugunduri, Chakradhara Rao Satyanarayana; Marino, Denis; Kuntzinger, Mélanie; ... Ansari Djaberi, Marc Georges

Thesis supervisions

unige:114515

Understanding and predicting the association of intrinsic and extrinsic factors of pharmacokinetic variability in the context of precision medicine: impact of genetic polymorphisms on CYP2D6-mediated drug-drug interactions

Storelli, Flavia;

2017

Scientific Articles

unige:90072	Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases	Romand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
unige:111045	Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)	Lloret-Linares, Célia; Daali, Youssef; Chevret, Sylvie; Nieto, Isabelle; ... Bellivier, Frank
unige:89991	Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane Transporters	Cusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
unige:99762	Impact of CYP2D6 functional allelic variations on phenoconversion and drug-drug interactions	Storelli, Flavia; Matthey, Alain; Lenglet, Sébastien; Thomas, Aurélien; ... Daali, Youssef
unige:98708	Plasma concentrations of transdermal fentanyl and buprenorphine in pigs (Sus scrofa domesticus)	Osorio Lujan, Suzanne; Habre, Walid; Daali, Youssef; Pan, Zhaoxin; Kronen, Peter W
unige:86303	Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study	Lloret-Linares, Célia; Rollason Gumprecht, Victoria; Ing Lorenzini, Kuntheavy; Samer, Caroline Flora; ... Besson, Marie
unige:98709	The Association of Combined GSTM1 and CYP2C9 Genotype Status with the Occurrence of Hemorrhagic Cystitis in Pediatric Patients Receiving Myeloablative Conditioning Regimen Prior to Allogeneic Hematopoietic Stem Cell Transplantation	Uppugunduri, Chakradhara Rao S; Storelli, Flavia; Mlakar, Vid; Huezo-Diaz Curtis, Patricia; ... Ansari Djaberi, Marc Georges
unige:97051	Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
unige:98706	Why has model-informed precision dosing not yet become common clinical reality? lessons from the past and a roadmap for the future	Darwich, A S; Ogungbenro, K; Vinks, A A; Powell, J R; ... Rostami-Hodjegan, A

2016

Scientific Articles

unige:85973	An extensive cocktail approach for rapid risk assessment of in vitro CYP450 direct reversible inhibition by xenobiotic exposure	Spaggiari, Dany; Daali, Youssef; Rudaz, Serge;
unige:75867	Aspirin response: Differences in serum thromboxane B2 levels between clinical studies	Brun, Charlotte; Daali, Youssef; Combescure, Christophe; Zufferey Bakos, Anne; ... Frelinger, Andrew L (3rd)
unige:86304	Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach	Marsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
unige:88690	Detection of busulfan adducts on proteins	Acosta Martin, Adelina Elena; Antinori Malaspina, Paola; Uppugunduri Satyanarayana, Chakradhara Rao; Daali, Youssef; ... Lescuyer, Pierre
unige:86308	Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method	Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
unige:88462	Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis	Seredenin, Tamara; Nayernia, Zeynab; Sorce, Silvia; Maghzal, Ghassan J; ... Jaquet, Vincent