Guillarme, Davy

 
 
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2020

Scientific Articles

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Automated middle-up approach for the characterization of biotherapeutic products by combining on-line hinge-specific digestion with RPLC-HRMS analysisCamperi, Julien; Guillarme, Davy; Lei, Ming; Stella, Cinzia;
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Coupling non-denaturing chromatography to mass spectrometry for the characterization of monoclonal antibodies and related productsFarsang, Evelin; Guillarme, Davy; Veuthey, Jean-Luc; Beck, Alain; ... Fekete, Szabolcs
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Determination of size variants by CE-SDS for approved therapeutic antibodies: Key implications of subclasses and light chain specificitiesWagner, Elsa; Colas, Olivier; Chenu, Stéphane; Goyon, Alexandre; ... Beck, Alain
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Editorial for the virtual special issue SEP 2019Guillarme, Davy; West, Caroline;
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Evaluation of additives on reversed-phase chromatography of monoclonal antibodies using a 1000 Å stationary phaseMcCalley, David V.; Guillarme, Davy;
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From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodiesGoyon, Alexandre; Dai, Lu; Chen, Tao; Wei, Bingchuan; ... Stella, Cinzia
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Improving selectivity and performing online on-column fractioning in liquid chromatography for the separation of therapeutic biopharmaceutical productsFekete, Szabolcs; Ritchie, Harald; Lawhorn, Jason; Veuthey, Jean-Luc; Guillarme, Davy
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Interlaboratory and Interplatform Study of Steroids Collision Cross Section by Traveling Wave Ion Mobility SpectrometryHernández-Mesa, Maykel; D'Atri, Valentina; Barknowitz, Gitte; Fanuel, Mathieu; ... Le Bizec, Bruno
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Non-invasive targeted iontophoretic delivery of cetuximab to skinLapteva, Maria; Sallam, Marwa A.; Goyon, Alexandre; Guillarme, Davy; ... Kalia, Yogeshvar
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Supercritical fluid chromatography–mass spectrometry in routine anti-doping analyses: Estimation of retention time variability under reproducible conditionsLosacco, Gioacchino Luca; Marconetto, Elisa; Nicoli, Raul; Kuuranne, Tiia; ... Guillarme, Davy

Book Chapters

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Drug Loading and Distribution of ADCs After Reduction or IdeS Digestion and ReductionWagner-Rousset, Elsa; Colas, Olivier; François, Yannis-Nicolas; Heinisch, Sabine; ... Beck, Alain

2019

Scientific Articles

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A generic workflow for the characterization of therapeutic monoclonal antibodies—application to daratumumabDuivelshof, Bastiaan; Fekete, Szabolcs; Guillarme, Davy; D'Atri, Valentina;
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A scoring approach for multi-platform acquisition in metabolomicsPezzatti, Julian; Gonzalez Ruiz, Victor; Codesido Sanchez, Santiago; Gagnebin, Yoric; ... Rudaz, Serge
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Analytical strategies for the determination of amino acids: Past, present and future trendsFerre, Sabrina Myriam; Gonzalez Ruiz, Victor; Guillarme, Davy; Rudaz, Serge;
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Anticorps monoclonaux biosimilairesBeck, Alain; Guillarme, Davy; Fleury-Souverain, Sandrine; Bodier-Montagutelli, Elsa; Respaud, Renaud
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Apparent efficiency of serially coupled columns in gradient elution liquid chromatography: Extension to the combination of any column formatsCodesido Sanchez, Santiago; Rudaz, Serge; Guillarme, Davy; Horváth, Krisztián; Fekete, Szabolcs
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Characterization of charge variants for antibody-based biopharmaceuticals by mass spectrometryGuillarme, Davy; Hage, David S.;
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Computer-assisted UHPLC–MS method development and optimization for the determination of 24 antineoplastic drugs used in hospital pharmacyGuichard, Nicolas; Fekete, Szabolcs; Guillarme, Davy; Bonnabry, Pascal; Fleury, Sandrine
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Cutting-edge multi-level analytical and structural characterization of antibody-drug conjugates: present and futureBeck, Alain; D'Atri, Valentina; Ehkirch, Anthony; Fekete, Szabolcs; ... Cianférani, Sarah
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Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implicationsDuivelshof, Bastiaan; Jiskoot, Wim; Beck, Alain; Veuthey, Jean-Luc; ... D'Atri, Valentina
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Impact of particle size gradients on the apparent efficiency of chromatographic columnsCodesido Sanchez, Santiago; Rudaz, Serge; Veuthey, Jean-Luc; Guillarme, Davy; ... Fekete, Szabolcs
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Is hydrophobic interaction chromatography the most suitable technique to characterize site-specific antibody-drug conjugates?D'Atri, Valentina; Pell, Reinhard; Clarke, Adrian; Guillarme, Davy; Fekete, Szabolcs
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Optimization of MS-Compatible Mobile Phases for IEX Separation of Monoclonal AntibodiesFarsang, Evelin; Murisier, Amarande; Horvath, Krisztián; Colas, Olivier; ... Fekete, Szabolcs
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Optimization of MS-Compatible Mobile Phases for IEX Separation of Monoclonal AntibodiesFarsang, Evelin; Murisier, Amarande; Horvath, Krisztian; Colas, Olivier; ... Fekete, Szabolcs
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Orthogonal Middle-up Approaches for Characterization of the Glycan Heterogeneity of Etanercept by Hydrophilic Interaction Chromatography Coupled to High-Resolution Mass SpectrometryD'Atri, Valentina; Nováková, Lucie; Fekete, Szabolcs; Stoll, Dwight; ... Guillarme, Davy
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Practical considerations on the particle size and permeability of ion-exchange columns applied to biopharmaceutical separationsMurisier, Amarande; Lauber, Matthew; Shiner, Stephen J.; Guillarme, Davy; Fekete, Szabolcs
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Proof of Concept To Achieve Infinite Selectivity for the Chromatographic Separation of Therapeutic ProteinsFekete, Szabolcs; Beck, Alain; Veuthey, Jean-Luc; Guillarme, Davy;
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Recent Advances in Chromatography for Pharmaceutical AnalysisD'Atri, Valentina; Fekete, Szabolcs; Clarke, Adrian; Veuthey, Jean-Luc; Guillarme, Davy
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Streamlined Characterization of an Antibody–Drug Conjugate by Two-Dimensional and Four-Dimensional Liquid Chromatography/Mass SpectrometryGoyon, Alexandre; Kim, Michael; Dai, Lu; Cornell, Christopher; ... Stella, Cinzia
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Supercritical fluid chromatography – Mass spectrometry: Recent evolution and current trendsLosacco, Gioacchino Luca; Veuthey, Jean-Luc; Guillarme, Davy;
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The Emergence of Universal Chromatographic Methods in the Research and Development of New Drug SubstancesRegalado, Erik L.; Haidar Ahmad, Imad A.; Bennett, Raffeal; D'Atri, Valentina; ... Guillarme, Davy
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Tuning selectivity in cation-exchange chromatography applied for monoclonal antibody separations, part 1: Alternative mobile phases and fine tuning of the separationFarsang, Evelin; Murisier, Amarande; Horváth, Krisztián; Beck, Alain; ... Fekete, Szabolcs
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Tuning selectivity in cation-exchange chromatography applied for monoclonal antibody separations, part 2: Evaluation of recent stationary phasesMurisier, Amarande; Farsang, Evelin; Horváth, Krisztián; Lauber, Matthew; ... Fekete, Szabolcs
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Utility of dry load injection for an efficient natural products isolation at the semi-preparative chromatographic scaleFerreira Queiroz, Emerson; Alfattani, Abdulelah; Afzan, Adlin; Marcourt, Laurence; ... Wolfender, Jean-Luc
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Utilizing Multidimensional LC–MS for Hydroxyl Radical Footprinting AnalysisCamperi, Julien; Schick, Arthur John; Guillarme, Davy; Wecksler, Aaron;

Thesis supervisions

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Évaluation de méthodes chromatographiques et électrophorétiques pour la caractérisation de protéines thérapeutiquesGoyon, Alexandre;

2018

Scientific Articles

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Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?D'Atri, Valentina; Causson, Tim; Hernandez-Alba, Oscar; Mutabazi, Aline; ... Guillarme, Davy
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An attempt to characterize the human Chorionic Gonadotropin protein by reversed phase liquid chromatography coupled with high-resolution mass spectrometry at the intact levelCamperi, Julien; Combes, Audrey; Guibourdenche, Jean; Guillarme, Davy; ... Delaunay, Nathalie
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An Online Four-Dimensional HIC×SEC-IM×MS Methodology for Proof-of-Concept Characterization of Antibody Drug ConjugatesEhkirch, Antony; D'Atri, Valentina; Rouviere, Florent; Hernandez-Alba, Oscar; ... Cianferani, Sarah
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Apparent efficiency of serially coupled columns in isocratic and gradient elution modesFekete, Szabolcs; Codesido Sanchez, Santiago; Rudaz, Serge; Guillarme, Davy; Horváth, Krisztián
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Applicability of supercritical fluid chromatography–mass spectrometry to metabolomics. I – Optimization of separation conditions for the simultaneous analysis of hydrophilic and lipophilic substancesDesfontaine, Vincent; Losacco, Gioacchino Luca; Gagnebin, Yoric; Pezzatti, Julian; ... Guillarme, Davy
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Characterization of an antibody-drug conjugate by hydrophilic interaction chromatography coupled to mass spectrometryD'Atri, Valentina; Fekete, Szabolcs; Stoll, Dwight; Lauber, Matthew; ... Guillarme, Davy
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Characterizing various monoclonal antibodies with milder reversed phase chromatography conditionsBobaly, Balazs; D'Atri, Valentina; Lauber, Matthew; Beck, Alain; ... Fekete, Szabolcs
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Current possibilities of liquid chromatography for the characterization of antibody-drug conjugatesBobaly, Balazs; Fleury, Sandrine; Beck, Alain; Veuthey, Jean-Luc; ... Fekete, Szabolcs
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Development of a lc–ms/ms method for the determination of isomeric glutamyl peptides in food ingredientsDesfontaine, Vincent; Goyon, Alexandre; Veuthey, Jean-Luc; Charve, Joséphine; Guillarme, Davy
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Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic AntibodiesStoll, Dwight R.; Harmes, David C.; Staples, Gregory O.; Potter, Oscar G.; ... Beck, Alain
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Editorial for the special issue entitled “supercritical fluid chromatography – mass spectrometry”Guillarme, Davy; Veuthey, Jean-Luc;
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Extending the limits of size exclusion chromatography: Simultaneousseparation of free payloads and related species from antibody drugconjugates and their aggregatesGoyon, Alexandre; Sciascera, Luca; Clarke, Adrien; Guillarme, Davy; Pell, Reinhard
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First inter-laboratory study of a Supercritical Fluid Chromatography method for the determination of pharmaceutical impuritiesDispas, Amandine; Marini, Roland; Desfontaine, Vincent; Veuthey, Jean-Luc; ... Hubert, Philippe
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High-resolution separation of monoclonal antibodies mixtures and their charge variants by an alternative and generic CZE methodGoyon, Alexandre; Francois, Yannis Nicolas; Colas, Olivier; Beck, Alain; ... Guillarme, Davy
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