2018

Scientific Articles

unige:111010	Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction	Lander, Sharon S; Khan, Usman; Lewandowski, Nicole; Chakraborty, Darpan; ... Gaisler-Salomon, Inna
unige:110984	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis	Karaca Emre, Melis; Martin-Levilain, Juliette; Grimaldi, Mariagrazia; Li, Lingzi; ... Maechler, Pierre

2017

Scientific Articles

unige:99070	Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression	Brun, Julia; Berthou, Flavien; Trajkovski, Mirko; Maechler, Pierre; ... Bonnet, Nicolas
unige:101802	Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions	Kaczmarek, P; Skrzypski, M; Pruszynska-Oszmalek, E; Sassek, M; ... Strowski, M Z
unige:99220	Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?	Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; ... Maechler, Pierre
unige:100805	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation	Hohnholt, Michaela C; Andersen, Vibe H; Andersen, Jens V; Christensen, Sofie K; ... Waagepetersen, Helle S
unige:99221	Glutamate pathways of the beta-cell and the control of insulin secretion	Maechler, Pierre;
unige:96833	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia	Grimaldi, Mariagrazia; Karaca Emre, Melis; Latini, Livia; Brioudes, Estelle; ... Maechler, Pierre
unige:100806	Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production	Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; ... Donath, Marc Y
unige:99222	Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity	Li, Ning; Karaca Emre, Melis; Maechler, Pierre;

Thesis supervisions

unige:101702

Mitochondrial function and morphology in prohibitin 2 deleted ß-cells and hepatocytes

Li, Lingzi;

2016

Scientific Articles

unige:89723	Activation of nicotinic acetylcholine receptors decreases apoptosis in human and female murine pancreatic islets	Klee, Philippe; Bosco, Domenico; Guerardel, Audrey; Somm, Emmanuel; ... Schwitzgebel Luscher, Valérie
unige:89722	Beta-cell mitochondrial carriers and the diabetogenic stress response	Brun, Thierry; Maechler, Pierre;
unige:87986	Channels and transporters in cell metabolism	Sonveaux, Pierre; Maechler, Pierre; Martinou, Jean-Claude;
unige:89724	Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells	Schmidt, Søren Fisker; Madsen, Jesper Grud Skat; Frafjord, Kari Østerli; Poulsen, Lars la Cour; ... Mandrup, Susanne
unige:89721	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity	Vetterli, Laurene Marine; Carobbio, Stefania; Frigerio, Francesca; Karaca Emre, Melis; Maechler, Pierre

Thesis supervisions

unige:91727

Studies on S445L GDH mutation associated with both Hyperinsulinism/Hyperammonemia syndrome and epilepsy

Grimaldi, Mariagrazia;

2015

Scientific Articles

unige:72775	Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?	Wollheim, Claes; Maechler, Pierre;
unige:77865	Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets	Brun, Thierry; Li, Ning; Jourdain, Alexis; Gaudet, Pascale; ... Maechler, Pierre
unige:77866	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution	Karaca Emre, Melis; Frigerio, Francesca; Migrenne, Stephanie; Martin-Levilain, Juliette; ... Maechler, Pierre
unige:74638	Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes	Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite
unige:75016	Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes	Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite
unige:46795	Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells	Aragón, F; Karaca Emre, Melis; Novials, A; Maldonado, R; ... Rubí, B

2014

Scientific Articles

unige:46794

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

Sileno, Sara; D'Oria, Valentina; Stucchi, Riccardo; Alessio, Massimo; ... Massa, Ornella

2013

Scientific Articles

unige:36468	Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids	Brun, Thierry; Scarcia, Pasquale; Li, Ning; Gaudet, Pascale; ... Maechler, Pierre
unige:33351	Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter	Karaca Emre, Melis; Maechler, Pierre;
unige:28233	Hepatic glucose sensing is required to preserve β cell glucose competence	Seyer, Pascal; Vallois, David; Poitry-Yamate, Carole; Schutz, Frédéric; ... Thorens, Bernard
unige:32131	Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development	Supale, Sachin; Thorel, Fabrizio; Merkwirth, Carsten; Gjinovci, Asllan; ... Maechler, Pierre
unige:33357	Mitochondrial function and insulin secretion	Maechler, Pierre;
unige:28015	Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.	Zhang, Yanling; Zhen, Wei; Maechler, Pierre; Liu, Dongmin;
unige:28010	Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.	Russo, Lucia; Marsella, Claudia; Nardo, Giovanni; Massignan, Tania; ... Massa, Ornella

Thesis supervisions

unige:27521

Generation and characterization of pancreatic ß-Cell specific Prohibitin-2 knockout mice

Supale, Sachin;

2012

Scientific Articles

unige:26263	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission	Frigerio, Francesca Alda; Karaca Emre, Melis; De Roo, Mathias; Mlynárik, Vladimír; ... Maechler, Pierre
unige:28016	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase	Vetterli, Laurene Marine; Carobbio, Stefania; Pournourmohammadi, Shirin; Martin-Del-Rio, Rafael; ... Maechler, Pierre
unige:28231	Mitochondria in endocrinology	Maechler, Pierre;
unige:28014	Mitochondrial dysfunction in pancreatic β cells	Supale, Sachin; Li, Ning; Brun, Thierry; Maechler, Pierre;
unige:28230	Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?	Li, Ning; Stojanovski, Suzana; Maechler, Pierre;
unige:28232	Mitochondrial signal transduction in pancreatic β-cells	Maechler, Pierre;
unige:28039	NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion	Li, Ning; Li, Bin; Brun, Thierry; Deffert-Delbouille, Christine; ... Maechler, Pierre
unige:28013	Procyanidins modify insulinemia by affecting insulin production and degradation	Castell-Auví, Anna; Cedó, Lídia; Pallarès, Victor; Blay, M Teresa; ... Ardévol, Anna

2011

Scientific Articles

unige:25301	A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes	Casimir, Marina Shamini; de Andrade, Paula B; Gjinovci, Asllan; Montani, Jean-Pierre; ... Dulloo, Abdul G
unige:25320	ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells	Boergesen, Michael; Poulsen, Lars la Cour; Schmidt, Søren Fisker; Frigerio, Francesca; ... Mandrup, Susanne
unige:25393	Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells	Cumaoğlu, Ahmet; Rackova, Lucia; Stefek, Milan; Kartal, Murat; ... Karasu, Cimen
unige:25507	From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis	Karaca Emre, Melis; Frigerio, Francesca; Maechler, Pierre;
unige:25350	Non-invasive imaging of ferucarbotran labeled INS-1E cells and rodent islets in vitro and in transplanted diabetic rats	Auer, Veronika J; Bucher, Julian; Schremmer-Danninger, Elisabeth; Paulmurugan, Ramasamy; ... Berger, Frank
unige:25508	Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells	Račková, Lucia; Cumaoğlu, Ahmet; Bağrıacık, E Umit; Štefek, Milan; ... Karasu, Çimen
unige:25240	Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism	Vetterli, Laurene Marine; Brun, Thierry; Giovannoni, Laurianne; Bosco, Domenico; Maechler, Pierre
unige:25506	Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis	Vetterli, Laurene Marine; Maechler, Pierre;

Thesis supervisions

unige:16081	Etude de la sensibilité au glucose et du couplage métabolisme-sécrétion dans les cellules d'insulinome INS-1E durant deux années de culture continue	Merglen, Arnaud;
unige:15846	Generation and characterization of an inducible conditional b-cell-specific glutamate dehydrogenase knockout mouse	Vetterli, Laurene Marine;