2022

Scientific Articles

unige:159563

Glucolipotoxicity promotes the capacity of the glycerolipid/NEFA cycle supporting the secretory response of pancreatic beta cells

Oberhauser, Lucie; Jiménez-Sánchez, Cecilia; Madsen, Jesper Grud Skat; Duhamel, Dominique; ... Maechler, Pierre

2021

Scientific Articles

unige:159028	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα	Stojanovic, Ozren; Altirriba, Jordi; Rigo, Dorothée; Spiljar, Martina; ... Trajkovski, Mirko
unige:154318	Glutamate dehydrogenase is important for ammonia fixation and amino acid homeostasis in brain during hyperammonemia	Voss, Caroline M.; Arildsen, Lene; Nissen, Jakob D.; Waagepetersen, Helle S.; ... Walls, Anne B.
unige:159626	Lipid-induced adaptations of the pancreatic beta-cell to glucotoxic conditions sustain insulin secretion	Oberhauser, Lucie; Maechler, Pierre;
unige:156448	Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation	Merlin, Johanna; Ivanov, Stoyan; Dumont, Adélie; Sergushichev, Alexey; ... Yvan-Charvet, Laurent

2020

Scientific Articles

unige:137266	AMP-activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics	Voss, Caroline M; Andersen, Jens V; Jakobsen, Emil; Siamka, Olga; ... Waagepetersen, Helle S
unige:137262	AMPK profiling in rodent and human pancreatic beta-cells under nutrient-rich metabolic stress	Brun, Thierry; Jimenez-Sanchez, Cécilia; Madsen, Jesper Grud Skat; Hadadi, Noushin; ... Maechler, Pierre
unige:132087	Hyperinsulinism associated with GLUD1 mutation: allosteric regulation and functional characterization of p.G446V glutamate dehydrogenase	Luczkowska, Karolina; Stekelenburg, Caroline; Sloan Bena, Frédérique; Ranza, Emmanuelle Nathalie; ... Maechler, Pierre
unige:145494	Macrophage-derived glutamine boosts satellite cells and muscle regeneration	Shang, Min; Cappellesso, Federica; Amorim, Ricardo; Serneels, Jens; ... Mazzone, Massimiliano
unige:145502	Mitochondrial carriers regulating insulin secretion profiled in human islets upon metabolic stress	Jiménez-Sánchez, Cecilia; Brun, Thierry; Maechler, Pierre;
unige:127987	Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E β-cells alongside altered metabolism-secretion coupling	Oberhauser, Lucie; Granziera, Sabrina; Colom Diego, Adai; Goujon, Antoine; ... Maechler, Pierre

Thesis supervisions

unige:145909

Glutamate dehydrogenase, hyperammonemia, and HI/HA syndrome: Study on the contribution by the liver

Luczkowska, Karolina;

2019

Scientific Articles

unige:116616	Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling	Bartley, Clarissa; Brun, Thierry; Oberhauser, Lucie; Grimaldi, Mariagrazia; ... Maechler, Pierre
unige:111010	Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction	Lander, Sharon S; Khan, Usman; Lewandowski, Nicole; Chakraborty, Darpan; ... Gaisler-Salomon, Inna
unige:122600	In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way	Li, Lingzi; Martin-Levilain, Juliette; Jimenez-Sanchez, Cécilia; Karaca Emre, Melis; ... Maechler, Pierre
unige:126176	Metabolomics identifies a biomarker revealing in vivo loss of functional ß-cell mass before diabetes onset	Li, Lingzi; Krznar, Petra; Erban, Alexander; Agazzi, Andréa; ... Maechler, Pierre
unige:124746	Reply to Mishra: prohibitin heterodimers—a complex time dependence for carcinogenesis	Martin-Levilain, Juliette; Li, Lingzi; Maechler, Pierre;
unige:116615	Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion	Casimir, Marina Shamini; Chaffard, Gaelle; Maechler, Pierre;

Professional Articles

unige:116614

L'exposition des cellules bêta au fructose potentialise la sécrétion d'insuline via une signalisation par l'ATP

Brun, Thierry; Bartley, Clarissa; Maechler, Pierre;

Thesis supervisions

unige:119430	Characterization of KIAA2022 and generation of knock-out mice indicates a role in maintaining genomic stability	Stekelenburg, Caroline;
unige:117296	Role Of FFAR1 in the response of INS-1E β-cells to glucolipotoxicity	Oberhauser, Lucie;

2018

Scientific Articles

unige:100805	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation	Hohnholt, Michaela C; Andersen, Vibe H; Andersen, Jens V; Christensen, Sofie K; ... Waagepetersen, Helle S
unige:110984	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis	Karaca Emre, Melis; Martin-Levilain, Juliette; Grimaldi, Mariagrazia; Li, Lingzi; ... Maechler, Pierre

2017

Scientific Articles

unige:99070	Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression	Brun, Julia; Berthou, Flavien; Trajkovski, Mirko; Maechler, Pierre; ... Bonnet, Nicolas
unige:101802	Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions	Kaczmarek, P; Skrzypski, M; Pruszynska-Oszmalek, E; Sassek, M; ... Strowski, M Z
unige:99220	Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?	Pournourmohammadi, Shirin; Grimaldi, Mariagrazia; Stridh, Malin H; Lavallard, Vanessa; ... Maechler, Pierre
unige:99221	Glutamate pathways of the beta-cell and the control of insulin secretion	Maechler, Pierre;
unige:96833	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia	Grimaldi, Mariagrazia; Karaca Emre, Melis; Latini, Livia; Brioudes, Estelle; ... Maechler, Pierre
unige:100806	Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production	Dalmas, Elise; Lehmann, Frank M; Dror, Erez; Wueest, Stephan; ... Donath, Marc Y
unige:99222	Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity	Li, Ning; Karaca Emre, Melis; Maechler, Pierre;

Thesis supervisions

unige:101702

Mitochondrial function and morphology in prohibitin 2 deleted ß-cells and hepatocytes

Li, Lingzi;

2016

Scientific Articles

unige:89723	Activation of nicotinic acetylcholine receptors decreases apoptosis in human and female murine pancreatic islets	Klee, Philippe; Bosco, Domenico; Guerardel, Audrey; Somm, Emmanuel; ... Schwitzgebel Luscher, Valérie
unige:89722	Beta-cell mitochondrial carriers and the diabetogenic stress response	Brun, Thierry; Maechler, Pierre;
unige:87986	Channels and transporters in cell metabolism	Sonveaux, Pierre; Maechler, Pierre; Martinou, Jean-Claude;
unige:89724	Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells	Schmidt, Søren Fisker; Madsen, Jesper Grud Skat; Frafjord, Kari Østerli; Poulsen, Lars la Cour; ... Mandrup, Susanne
unige:89721	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity	Vetterli, Laurene Marine; Carobbio, Stefania; Frigerio, Francesca; Karaca Emre, Melis; Maechler, Pierre

Thesis supervisions

unige:91727

Studies on S445L GDH mutation associated with both Hyperinsulinism/Hyperammonemia syndrome and epilepsy

Grimaldi, Mariagrazia;

2015

Scientific Articles

unige:72775	Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?	Wollheim, Claes; Maechler, Pierre;
unige:77865	Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets	Brun, Thierry; Li, Ning; Jourdain, Alexis; Gaudet, Pascale; ... Maechler, Pierre
unige:77866	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution	Karaca Emre, Melis; Frigerio, Francesca; Migrenne, Stephanie; Martin-Levilain, Juliette; ... Maechler, Pierre
unige:75016	Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes	Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite
unige:74638	Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes	Lukowski, Samuel; Fish, Richard; Martin-Levilain, Juliette; Gonelle-Gispert, Carmen; ... Neerman Arbez, Marguerite
unige:46795	Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells	Aragón, F; Karaca Emre, Melis; Novials, A; Maldonado, R; ... Rubí, B

2014

Scientific Articles

unige:46794

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

Sileno, Sara; D'Oria, Valentina; Stucchi, Riccardo; Alessio, Massimo; ... Massa, Ornella

2013

Scientific Articles

unige:36468	Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids	Brun, Thierry; Scarcia, Pasquale; Li, Ning; Gaudet, Pascale; ... Maechler, Pierre
unige:33351	Development of Mice with Brain-Specific Deletion of Floxed Glud1 (Glutamate Dehydrogenase 1) Using Cre Recombinase Driven by the Nestin Promoter	Karaca Emre, Melis; Maechler, Pierre;
unige:28233	Hepatic glucose sensing is required to preserve β cell glucose competence	Seyer, Pascal; Vallois, David; Poitry-Yamate, Carole; Schutz, Frédéric; ... Thorens, Bernard
unige:32131	Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development	Supale, Sachin; Thorel, Fabrizio; Merkwirth, Carsten; Gjinovci, Asllan; ... Maechler, Pierre
unige:33357	Mitochondrial function and insulin secretion	Maechler, Pierre;
unige:28015	Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB.	Zhang, Yanling; Zhen, Wei; Maechler, Pierre; Liu, Dongmin;