2019

Scientific Articles

unige:118580	A case report of cholinergic rebound syndrome following abrupt low-dose clozapine discontinuation in a patient with type I bipolar affective disorder	Galova, Andréa; Berney, Patricia Elisabeth; Desmeules, Jules Alexandre; Sergentanis, Ioannis; Besson, Marie
unige:128196	Cytochrome P450 1A2 activity and incidence of thyroid disease and cancer after chronic or acute exposure to dioxins	Samer, Caroline Flora; Gloor, Yvonne Sylvia; Rollason Gumprecht, Victoria; Guessous, Idris; ... Daali, Youssef
unige:126844	Development of a predictive score for potentially avoidable hospital readmissions for general internal medicine patients	Blanc, Anne-Laure; Fumeaux, Thierry; Stirnemann, Jérôme; Dupuis Lozeron, Elise; ... Bonnabry, Pascal
unige:128192	Interaction between Fexofenadine and CYP Phenotyping Probe Drugs in Geneva Cocktail	Bosilkovska Weisskopf, Marija; Magliocco, Gaëlle; Desmeules, Jules Alexandre; Samer, Caroline Flora; Daali, Youssef
unige:134650	Liquid Chromatography-Tandem Mass Spectrometry Method for Ticagrelor and its Active Metabolite Determination in Human Plasma: Application to a Pharmacokinetic Study	Marsousi, Niloufar; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef;
unige:127240	Perioperative intravenous low-dose ketamine for neuropathic pain after major lower back surgery: A randomized, placebo-controlled study	Czarnetzki, Christoph; Desmeules, Jules Alexandre; Tessitore, Enrico; Faundez, Antonio; ... Tramer, Martin
unige:121245	Phenotyping of human CYP450 enzymes by endobiotics: current knowledge and methodological approaches	Magliocco, Gaëlle; Thomas, Aurélien; Desmeules, Jules Alexandre; Daali, Youssef;
unige:121056	Physiologically-based pharmacokinetic modeling for the prediction of CYP2D6-mediated gene-drug-drug interactions	Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
unige:134665	Pourquoi proposer la thérapie cognitivo-comportementale dans les douleurs chroniques ?	Souche, Alain; Piguet, Valérie; Desmeules, Jules Alexandre; Cedraschi, Christine;
unige:120073	Safety issues of pharmacological acute pain treatment in children	Rodieux, Frédérique; Piguet, Valérie; Desmeules, Jules Alexandre; Samer, Caroline Flora;
unige:128198	Snapshot of proton pump inhibitors prescriptions in a tertiary care hospital in Switzerland: less is more?	Lenoir, Camille; El Biali, Myriam; Luthy, Christophe; Grosgurin, Olivier; ... Rollason Gumprecht, Victoria
unige:128193	Toward precision medicine in pediatric population using cytochrome P450 phenotyping approaches and physiologically based pharmacokinetic modeling	Magliocco, Gaëlle; Rodieux, Frédérique; Desmeules, Jules Alexandre; Samer, Caroline Flora; Daali, Youssef

Thesis supervisions

unige:121673

Proteomic phenotyping of CNS cells exposed to inflammatory stimuli and opioids

Dozio, Vito;

2018

Scientific Articles

unige:110999	Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives	Storelli, Flavia; Samer, Caroline Flora; Reny, Jean-Luc; Desmeules, Jules Alexandre; Daali, Youssef
unige:110974	Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes	Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
unige:115338	Gestion de la douleur aiguë chez les patients sous traitements de substitution aux opioïdes	Manguzzi, Elena; Wainstein, Laura; Desmeules, Jules Alexandre; Broers, Barbara;
unige:111012	Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites	Marsousi, Niloufar; Daali, Youssef; Fontana, Pierre; Reny, Jean-Luc; ... Samer, Caroline Flora
unige:115534	Phenotypic Assessment of Drug Metabolic Pathways and P-Glycoprotein in Patients Treated With Antidepressants in an Ambulatory Setting	Lloret-Linares, Célia; Bosilkovska Weisskopf, Marija; Daali, Youssef; Gex-Fabry, Marianne; ... Besson, Marie
unige:98710	Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
unige:115334	Prescription des opioïdes chez les patients vulnérables : les enfants et les personnes âgées. Recommandations pratiques	Rodieux, Frédérique; Lloret-Linares, Célia; Piguet, Valérie; Desmeules, Jules Alexandre;
unige:110991	Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report	Aebischer, Gaspard; Ing Lorenzini, Kuntheavy; Tomala, Simon; Desmeules, Jules Alexandre; ... Samer, Caroline Flora
unige:107473	When the Safe Alternative Is Not That Safe: Tramadol Prescribing in Children	Rodieux, Frédérique; Vutskits, Laszlo; Posfay Barbe, Klara; Habre, Walid; ... Samer, Caroline Flora

Thesis supervisions

unige:114515

Understanding and predicting the association of intrinsic and extrinsic factors of pharmacokinetic variability in the context of precision medicine: impact of genetic polymorphisms on CYP2D6-mediated drug-drug interactions

Storelli, Flavia;

2017

Scientific Articles

unige:98712	"Late" Withdrawal Syndrome after Carbamazepine In Utero Exposure in a CYP2C9 Slow Metabolizer Newborn	Passia, Evangelia; Rock, Nathalie; Pfister, Riccardo; Ing Lorenzini, Kuntheavy; ... Samer, Caroline Flora
unige:90072	Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases	Romand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
unige:111045	Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)	Lloret-Linares, Célia; Daali, Youssef; Chevret, Sylvie; Nieto, Isabelle; ... Bellivier, Frank
unige:89991	Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane Transporters	Cusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
unige:99762	Impact of CYP2D6 functional allelic variations on phenoconversion and drug-drug interactions	Storelli, Flavia; Matthey, Alain; Lenglet, Sébastien; Thomas, Aurélien; ... Daali, Youssef
unige:98702	PIM-Check: development of an international prescription-screening checklist designed by a Delphi method for internal medicine patients	Desnoyer, Aude; Blanc, Anne-Laure; Pourcher, Valérie; Besson, Marie; ... Guignard, Bertrand
unige:86303	Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study	Lloret-Linares, Célia; Rollason Gumprecht, Victoria; Ing Lorenzini, Kuntheavy; Samer, Caroline Flora; ... Besson, Marie
unige:97051	Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;

Thesis supervisions

unige:100121

CYP450-mediated drug-drug interactions: towards prediction and informed dose recommendation using physiologically-based pharmacokinetic (PBPK) modeling

Marsousi, Niloufar;

2016

Scientific Articles

unige:86304	Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach	Marsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
unige:86308	Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method	Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
unige:86301	Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells	Marsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
unige:86299	Le coût, ce n'est pas tout…à propos des médicaments génériques	Piguet, Valérie; D'Incau, Stéphanie; Besson, Marie; Desmeules, Jules Alexandre; Cedraschi, Christine
unige:78728	Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anesthetics	Ing Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
unige:78731	Pharmacogenomics of Oral Antithrombotic Drugs	Storelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre
unige:74558	Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe : Preliminary Report	Agnandji, Selidji T.; Yerly Ferrillo, Sabine; Auderset, Floriane; Combescure, Christophe; ... Siegrist, Claire-Anne
unige:90075	Prescriptions médicamenteuses potentiellement inappropriées en gériatrie: quels outils utiliser pour les détecter?	Desnoyer, Aude; Guignard, Bertrand; Lang, Pierre-Olivier; Desmeules, Jules Alexandre; ... Bonnabry, Pascal
unige:93800	Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect	Ing Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora
unige:78730	Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study	Bosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy; Uppugunduri Satyanarayana, Chakradhara Rao; Desmeules, Jules Alexandre; ... Escher, Monica
unige:86300	Snapshot of the prescribing practice for the clopidogrel and esomeprazole coprescription and cost evaluation of the application guidelines	Vernaz-Hegi, Nathalie; Rollason Gumprecht, Victoria; Adlere, Liene; Combescure, Christophe; ... Desmeules, Jules Alexandre
unige:86302	The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia	Ralvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie

Thesis supervisions

unige:84772

Influence de la maladie rénale chronique terminale sur la disposition et le métabolisme extra rénal des médicaments : exemple des inhibiteurs du récepteur P2Y12 à l'ADP

Bouatou, Yassine;

2015

Scientific Articles

unige:45606	A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients	Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
unige:78723	A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-up	Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
unige:75422	Assessing the affective load in the narratives of women suffering from fibromyalgia: the clinicians' appraisal	Cedraschi, Christine; Girard, Elodie Laure; Piguet, Valérie; Desmeules, Jules Alexandre; Allaz, Anne-Françoise
unige:78726	Cannabinoïdes médicaux dans les douleurs chroniques : aspects pharmacologiques	Ing Lorenzini, Kuntheavy; Broers, Barbara; Lalive d'Epinay, Patrice; Dayer, Pierre; ... Piguet, Valérie
unige:78721	Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist	Guignard, Bertrand; Bonnabry, Pascal; Perrier, Arnaud; Dayer, Pierre; ... Samer, Caroline Flora