Desmeules, Jules Alexandre

 
 
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2016

Scientific Articles

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Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferasesRomand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approachMarsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
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Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling MethodBosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
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Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cellsMarsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
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Le coût, ce n’est pas tout…à propos des médicaments génériquesPiguet, Valérie; D'Incau, Stéphanie; Besson, Marie; Desmeules, Jules Alexandre; Cedraschi, Christine
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Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anestheticsIng Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
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Pharmacogenomics of Oral Antithrombotic DrugsStorelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre
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Prescriptions médicamenteuses potentiellement inappropriées en gériatrie: quels outils utiliser pour les détecter?Desnoyer, Aude; Guignard, Bertrand; Lang, Pierre-Olivier; Desmeules, Jules Alexandre; ... Bonnabry, Pascal
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Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic DefectIng Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora
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Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective studyLloret-Linares, Célia; Rollason Gumprecht, Victoria; Ing Lorenzini, Kuntheavy; Samer, Caroline Flora; ... Besson, Marie
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Snapshot of the prescribing practice for the clopidogrel and esomeprazole coprescription and cost evaluation of the application guidelinesVernaz-Hegi, Nathalie; Rollason Gumprecht, Victoria; Adlere, Liene; Combescure, Christophe; ... Desmeules, Jules Alexandre
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The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesiaRalvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie

Thesis supervisions

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Influence de la maladie rénale chronique terminale sur la disposition et le métabolisme extra rénal des médicaments : exemple des inhibiteurs du récepteur P2Y12 à l'ADPBouatou, Yassine;

2015

Scientific Articles

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A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-upDerfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
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Assessing the affective load in the narratives of women suffering from fibromyalgia: the clinicians' appraisalCedraschi, Christine; Girard, Elodie Laure; Piguet, Valérie; Desmeules, Jules Alexandre; Allaz, Anne-Françoise
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Cannabinoïdes médicaux dans les douleurs chroniques : aspects pharmacologiquesIng Lorenzini, Kuntheavy; Broers, Barbara; Lalive d'Epinay, Patrice; Dayer, Pierre; ... Piguet, Valérie
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Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologistGuignard, Bertrand; Bonnabry, Pascal; Perrier, Arnaud; Dayer, Pierre; ... Samer, Caroline Flora
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Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-ReviewBouatou, Yassine; Samer, Caroline Flora; Fontana, Pierre; Daali, Youssef; Desmeules, Jules Alexandre
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GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteersBesson, Marie; Matthey, Alain; Daali, Youssef; Poncet, Antoine; ... Desmeules, Jules Alexandre
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Is pholcodine a dangerous cough suppressant?Ing Lorenzini, Kuntheavy; Desmeules, Jules Alexandre; Piguet, Valérie;
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Markers of Individual Drug Metabolism: Towards the Development of a Personalized Antidepressant PrescriptionLloret-Linares, Celia; Bellivier, Frank; Haffen, Emmanuel; Aubry, Jean-Michel; ... Besson, Marie
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P-glycoprotein: a clue to vitamin K antagonist stabilizationGschwind, Liliane; Rollason Gumprecht, Victoria; Boehlen, Françoise; Rebsamen, Michela; ... Desmeules, Jules Alexandre
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Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe : Preliminary ReportAgnandji, Selidji T.; Huttner, Angela; Zinser, Madeleine E.; Njuguna, Patricia; ... Siegrist, Claire-Anne
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Prescribing Generic Medication in Chronic Musculoskeletal Pain Patients: An Issue of Representations, Trust, and Experience in a Swiss CohortPiguet, Valérie; D'Incau, Stéphanie; Besson, Marie; Desmeules, Jules Alexandre; Cedraschi, Christine
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Prescription d’antidépresseurs dans le traitement de la douleur : rôle de la pharmacogénétiqueRodieux, Frédérique; Piguet, Valérie; Berney, Patricia Elisabeth; Desmeules, Jules Alexandre; Besson, Marie
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Providing Quality Therapeutics in Switzerland: Role of the Stakeholders and Recent Incentives for Further ImprovementsBesson, Marie; Samer, Caroline Flora; Rollason Gumprecht, Victoria; Dayer, Pierre; Desmeules, Jules Alexandre
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Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case StudyBosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy; Uppugunduri Satyanarayana, Chakradhara Rao; Desmeules, Jules Alexandre; ... Escher, Monica
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The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trialHuttner, Angela; Dayer, Julie-Anne; Yerly Ferrillo, Sabine; Combescure, Christophe; ... Siegrist, Claire-Anne
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Use of metamizole in children and the risk of agranulocytosis: Is the benefit worth the risk?Rollason Gumprecht, Victoria; Desmeules, Jules Alexandre;

Thesis supervisions

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Development and clinical validation of a low-dose phenotyping cocktail for cytochrome P450 and P-glycoprotein activity assessment using dried blood spotsBosilkovska Weisskopf, Marija;

2014

Scientific Articles

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A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patientsDerfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
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Central Pain Sensitization, COMT Val158Met Polymorphism, and Emotional Factors in FibromyalgiaDesmeules, Jules Alexandre; Chabert, Jocelyne; Rebsamen, Michela; Rapiti Aylward, Elisabetta; ... Cedraschi, Christine
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Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood SpotsBosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Rebsamen, Michela; ... Daali, Youssef
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Impact of clinical decision support guidelines on therapeutic drug monitoring of gentamicin in newbornsFonzo-christe, Caroline Cécile; Guignard, Bertrand; Zaugg, Claudia; Coehlo, Ana; ... Bonnabry, Pascal
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Improving the primary care physicians' decision making for fibromyalgia in clinical practice: development and validation of the Fibromyalgia Detection (FibroDetect®) screening toolBaron, Ralf; Perrot, Serge; Guillemin, Isabelle; Alegre, Cayetano; ... Arnould, Benoit
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Incorporation of Flurbiprofen in a 4-Drug Cytochrome P450 Phenotyping CocktailBosilkovska Weisskopf, Marija; Clement, Mallorie; Dayer, Pierre; Desmeules, Jules Alexandre; Daali, Youssef
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Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a reviewRollason Gumprecht, Victoria; Samer, Caroline Flora; Daali, Youssef; Desmeules, Jules Alexandre;
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Prediction of Metabolic Interactions With Oxycodone via CYP2D6 and CYP3A Inhibition Using a Physiologically Based Pharmacokinetic ModelMarsousi, Niloufar; Daali, Youssef; Rudaz, Serge; Almond, L; ... Samer, Caroline Flora
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Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasmaBosilkovska Weisskopf, Marija; Deglon, Julien; Samer, Caroline Flora; Walder, Bernhard; ... Daali, Youssef
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Snapshot of Prescribing Practice for Clopidogrel and Esomeprazole Co-Prescription and Cost Evaluation of Guidelines ApplicationVernaz, N; Rollason Gumprecht, Victoria; Adlere, Liene; Bonnabry, Pascal; Desmeules, Jules Alexandre
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Therapeutic drug monitoring of voriconazole: a case report of multiple drug interactions in a patient with an increased CYP2C19 activityBouatou, Yassine; Samer Fahem, Caroline Flora; Ing Lorenzini, Kuntheavy Roseline; Daali, Youssef; ... Escher, Monica

2013

Scientific Articles

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Antihyperalgesic Effect of the GABA(A) Ligand Clobazam in a Neuropathic Pain Model in Mice: A Pharmacokinetic-Pharmacodynamic StudyBesson, Marie; Daali, Youssef; Di Lio, Alessandra; Dayer, Pierre; ... Desmeules, Jules Alexandre
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Applications of CYP450 Testing in the Clinical SettingSamer, Caroline Flora; Ing Lorenzini, Kuntheavy; Rollason Gumprecht, Victoria; Daali, Youssef; Desmeules, Jules Alexandre
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Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trialMatthey, Alain; Cedraschi, Christine; Piguet, Valérie; Besson, Marie; ... Desmeules, Jules Alexandre
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Evaluation of anti-hyperalgesic and analgesic effects of two benzodiazepines in human experimental pain: a randomized placebo-controlled studyVuilleumier, Pascal; Besson, Marie; Desmeules, Jules Alexandre; Arendt-Nielsen, Lars; Curatolo, Michele
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Identification and weighting of the most critical "real-life" drug-drug interactions with acenocoumarol in a tertiary care hospitalGschwind, Liliane; Rollason Gumprecht, Victoria; Lovis, Christian; Boehlen, Françoise; ... Desmeules, Jules Alexandre
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Impact of CYP2C9 polymorphisms on the vulnerability to pharmacokinetic drug-drug interactions during acenocoumarol treatmentGschwind, Liliane; Rollason Gumprecht, Victoria; Boehlen, Françoise; Rebsamen, Michela; ... Desmeules, Jules Alexandre
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Influence of CYP2D6 activity on pre-emptive analgesia by the N-methyl-D-aspartate antagonist dextromethorphan in a randomized controlled trial of acute painEhret, Georg Benedikt; Daali, Youssef; Chabert, Jocelyne; Rebsamen, Michela; ... Desmeules, Jules Alexandre
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Pharmacokinetic interaction between prasugrel and ritonavir in healthy volunteersAncrenaz, Virginie; Deglon, Julien; Samer, Caroline Flora; Staub, Christian Olivier; ... Desmeules, Jules Alexandre
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