2018

Scientific Articles

unige:110999	Complex Drug-Drug-Gene-Disease Interactions Involving Cytochromes P450: Systematic Review of Published Case Reports and Clinical Perspectives	Storelli, Flavia; Samer, Caroline Flora; Reny, Jean-Luc; Desmeules, Jules Alexandre; Daali, Youssef
unige:110974	Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes	Storelli, Flavia; Desmeules, Jules Alexandre; Daali, Youssef;
unige:111012	Impact of Boosted Antiretroviral Therapy on the Pharmacokinetics and Efficacy of Clopidogrel and Prasugrel Active Metabolites	Marsousi, Niloufar; Daali, Youssef; Fontana, Pierre; Reny, Jean-Luc; ... Samer, Caroline Flora
unige:98710	Prediction of drug-drug interactions using physiologically-based pharmacokinetic models of CYP450 modulators included in Simcyp software	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;
unige:110991	Severe and persistent morphine-induced respiratory depression associated with ATP-Binding Cassette Subfamily B Member 1 and catechol-O-methyltransferase genetic defects: A case report	Aebischer, Gaspard; Ing Lorenzini, Kuntheavy; Tomala, Simon; Desmeules, Jules Alexandre; ... Samer, Caroline Flora
unige:107473	When the Safe Alternative Is Not That Safe: Tramadol Prescribing in Children	Rodieux, Frédérique; Vutskits, Laszlo; Posfay Barbe, Clara; Habre, Walid; ... Samer, Caroline Flora

2017

Scientific Articles

unige:98712	"Late" Withdrawal Syndrome after Carbamazepine In Utero Exposure in a CYP2C9 Slow Metabolizer Newborn	Passia, Evangelia; Rock, Nathalie; Pfister, Riccardo; Ing Lorenzini, Kuntheavy; ... Samer, Caroline Flora
unige:90072	Characterization of oxycodone in vitro metabolism by human cytochromes P450 and UDP-glucuronosyltransferases	Romand, Stéphanie Anne; Spaggiari, Dany; Marsousi, Niloufar; Samer, Caroline Flora; ... Rudaz, Serge
unige:111045	Exploring venlafaxine pharmacokinetic variability with a phenotyping approach, a multicentric french-swiss study (MARVEL study)	Lloret-Linares, Célia; Daali, Youssef; Chevret, Sylvie; Nieto, Isabelle; ... Bellivier, Frank
unige:89991	Hepatocyte Concentrations of Indocyanin Green (ICG) Reflects Transfer Rates Across Membrane Transporters	Cusin, Fabien; Azevedo, Liliana; Bonnaventure, Pierre; Desmeules, Jules Alexandre; ... Pastor, Catherine
unige:99762	Impact of CYP2D6 functional allelic variations on phenoconversion and drug-drug interactions	Storelli, Flavia; Matthey, Alain; Lenglet, Sébastien; Thomas, Aurélien; ... Daali, Youssef
unige:98702	PIM-Check: development of an international prescription-screening checklist designed by a Delphi method for internal medicine patients	Desnoyer, Aude; Blanc, Anne-Laure; Pourcher, Valérie; Besson, Marie; ... Guignard, Bertrand
unige:86303	Screening for genotypic and phenotypic variations in CYP450 activity in patients with therapeutic problems in a psychiatric setting, a retrospective study	Lloret-Linares, Célia; Rollason Gumprecht, Victoria; Ing Lorenzini, Kuntheavy; Samer, Caroline Flora; ... Besson, Marie
unige:97051	Usefulness of PBPK Modeling in Incorporation of Clinical Conditions in Personalized Medicine	Marsousi, Niloufar; Desmeules, Jules Alexandre; Rudaz, Serge; Daali, Youssef;

Thesis supervisions

unige:100121

CYP450-mediated drug-drug interactions: towards prediction and informed dose recommendation using physiologically-based pharmacokinetic (PBPK) modeling

Marsousi, Niloufar;

2016

Scientific Articles

unige:86304	Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach	Marsousi, Niloufar; Samer, Caroline Flora; Fontana, Pierre; Reny, Jean-Luc; ... Daali, Youssef
unige:86308	Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method	Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Thomas, Aurélien; ... Daali, Youssef
unige:86301	Intestinal permeability and P-glycoprotein-mediated efflux transport of ticagrelor in Caco-2 monolayer cells	Marsousi, Niloufar; Doffey-Lazeyras, Fabienne; Rudaz, Serge; Desmeules, Jules Alexandre; Daali, Youssef
unige:86299	Le coût, ce n’est pas tout…à propos des médicaments génériques	Piguet, Valérie; D'Incau, Stéphanie; Besson, Marie; Desmeules, Jules Alexandre; Cedraschi, Christine
unige:78728	Meta-xylene: identification of a new antigenic entity in hypersensitivity reactions to local anesthetics	Ing Lorenzini, Kuntheavy; Gay-Crosier Chabry, Fabienne; Piguet, Claude; Desmeules, Jules Alexandre;
unige:78731	Pharmacogenomics of Oral Antithrombotic Drugs	Storelli, Flavia; Daali, Youssef; Desmeules, Jules Alexandre; Reny, Jean-Luc; Fontana, Pierre
unige:74558	Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe : Preliminary Report	Agnandji, Selidji T.; Yerly Ferrillo, Sabine; Auderset, Floriane; Combescure, Christophe; ... Siegrist, Claire-Anne
unige:90075	Prescriptions médicamenteuses potentiellement inappropriées en gériatrie: quels outils utiliser pour les détecter?	Desnoyer, Aude; Guignard, Bertrand; Lang, Pierre-Olivier; Desmeules, Jules Alexandre; ... Bonnabry, Pascal
unige:93800	Rivaroxaban-Induced Hemorrhage Associated with ABCB1 Genetic Defect	Ing Lorenzini, Kuntheavy; Daali, Youssef; Fontana, Pierre; Desmeules, Jules Alexandre; Samer, Caroline Flora
unige:78730	Severe Vincristine-Induced Neuropathic Pain in a CYP3A5 Nonexpressor With Reduced CYP3A4/5 Activity: Case Study	Bosilkovska Weisskopf, Marija; Ing Lorenzini, Kuntheavy; Uppugunduri Satyanarayana, Chakradhara Rao; Desmeules, Jules Alexandre; ... Escher, Monica
unige:86300	Snapshot of the prescribing practice for the clopidogrel and esomeprazole coprescription and cost evaluation of the application guidelines	Vernaz-Hegi, Nathalie; Rollason Gumprecht, Victoria; Adlere, Liene; Combescure, Christophe; ... Desmeules, Jules Alexandre
unige:86302	The clobazam metabolite N-desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia	Ralvenius, William T; Acuña, Mario A; Benke, Dietmar; Matthey, Alain; ... Besson, Marie

Thesis supervisions

unige:84772

Influence de la maladie rénale chronique terminale sur la disposition et le métabolisme extra rénal des médicaments : exemple des inhibiteurs du récepteur P2Y12 à l'ADP

Bouatou, Yassine;

2015

Scientific Articles

unige:45606	A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients	Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
unige:78723	A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients - a twelve month follow-up	Derfuss, Tobias; Curtin, François; Guebelin, Claudia; Bridel, Claire; ... Lalive d'Epinay, Patrice
unige:75422	Assessing the affective load in the narratives of women suffering from fibromyalgia: the clinicians' appraisal	Cedraschi, Christine; Girard, Elodie Laure; Piguet, Valérie; Desmeules, Jules Alexandre; Allaz, Anne-Françoise
unige:78726	Cannabinoïdes médicaux dans les douleurs chroniques : aspects pharmacologiques	Ing Lorenzini, Kuntheavy; Broers, Barbara; Lalive d'Epinay, Patrice; Dayer, Pierre; ... Piguet, Valérie
unige:78721	Drug-related problems identification in general internal medicine: The impact and role of the clinical pharmacist and pharmacologist	Guignard, Bertrand; Bonnabry, Pascal; Perrier, Arnaud; Dayer, Pierre; ... Samer, Caroline Flora
unige:74755	Evidence-Based Choice of P2Y12 Inhibitors in End Stage Renal Disease Patients: A Mini-Review	Bouatou, Yassine; Samer, Caroline Flora; Fontana, Pierre; Daali, Youssef; Desmeules, Jules Alexandre
unige:54965	GABAergic modulation in central sensitization in humans: a randomized placebo-controlled pharmacokinetic-pharmacodynamic study comparing clobazam with clonazepam in healthy volunteers	Besson, Marie; Matthey, Alain; Daali, Youssef; Poncet, Antoine; ... Desmeules, Jules Alexandre
unige:78727	Is pholcodine a dangerous cough suppressant?	Ing Lorenzini, Kuntheavy; Desmeules, Jules Alexandre; Piguet, Valérie;
unige:78722	Markers of Individual Drug Metabolism: Towards the Development of a Personalized Antidepressant Prescription	Lloret-Linares, Celia; Bellivier, Frank; Haffen, Emmanuel; Aubry, Jean-Michel; ... Besson, Marie
unige:54964	P-glycoprotein: a clue to vitamin K antagonist stabilization	Gschwind, Liliane; Rollason Gumprecht, Victoria; Boehlen, Françoise; Rebsamen, Michela; ... Desmeules, Jules Alexandre
unige:78724	Prescribing Generic Medication in Chronic Musculoskeletal Pain Patients: An Issue of Representations, Trust, and Experience in a Swiss Cohort	Piguet, Valérie; D'Incau, Stéphanie; Besson, Marie; Desmeules, Jules Alexandre; Cedraschi, Christine
unige:78725	Prescription d’antidépresseurs dans le traitement de la douleur : rôle de la pharmacogénétique	Rodieux, Frédérique; Piguet, Valérie; Berney, Patricia Elisabeth; Desmeules, Jules Alexandre; Besson, Marie
unige:78720	Providing Quality Therapeutics in Switzerland: Role of the Stakeholders and Recent Incentives for Further Improvements	Besson, Marie; Samer, Caroline Flora; Rollason Gumprecht, Victoria; Dayer, Pierre; Desmeules, Jules Alexandre
unige:76362	The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial	Csaki Huttner, Angela; Dayer, Julie-Anne; Yerly Ferrillo, Sabine; Combescure, Christophe; ... Siegrist, Claire-Anne
unige:78729	Use of metamizole in children and the risk of agranulocytosis: Is the benefit worth the risk?	Rollason Gumprecht, Victoria; Desmeules, Jules Alexandre;

Thesis supervisions

unige:80013

Development and clinical validation of a low-dose phenotyping cocktail for cytochrome P450 and P-glycoprotein activity assessment using dried blood spots

Bosilkovska Weisskopf, Marija;

2014

Scientific Articles

unige:33237	Central Pain Sensitization, COMT Val158Met Polymorphism, and Emotional Factors in Fibromyalgia	Desmeules, Jules Alexandre; Chabert, Jocelyne; Rebsamen, Michela; Rapiti Aylward, Elisabetta; ... Cedraschi, Christine
unige:36848	Geneva Cocktail for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spots	Bosilkovska Weisskopf, Marija; Samer, Caroline Flora; Deglon, Julien; Rebsamen, Michela; ... Daali, Youssef
unige:38266	Impact of clinical decision support guidelines on therapeutic drug monitoring of gentamicin in newborns	Fonzo-Christe, Caroline Cécile; Guignard, Bertrand; Zaugg, Claudia; Coehlo, Ana; ... Bonnabry, Pascal
unige:43678	Improving the primary care physicians' decision making for fibromyalgia in clinical practice: development and validation of the Fibromyalgia Detection (FibroDetect®) screening tool	Baron, Ralf; Perrot, Serge; Guillemin, Isabelle; Alegre, Cayetano; ... Arnould, Benoit
unige:38265	Incorporation of Flurbiprofen in a 4-Drug Cytochrome P450 Phenotyping Cocktail	Bosilkovska Weisskopf, Marija; Clement, Mallorie; Dayer, Pierre; Desmeules, Jules Alexandre; Daali, Youssef
unige:38282	Prediction by pharmacogenetics of safety and efficacy of non-steroidal anti- inflammatory drugs: a review	Rollason Gumprecht, Victoria; Samer, Caroline Flora; Daali, Youssef; Desmeules, Jules Alexandre;