Wollheim, Claes

 
 
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2018

Scientific Articles

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Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate DehydrogenaseAndersson, Lotta E.; Shcherbina, Liliya; Al-Majdoub, Mahmoud; Vishnu, Neelanjan; ... Spégel, Peter
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Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose productionTubbs, Emily; Axelsson, Annika S; Vial, Guillaume; Wollheim, Claes; ... Rosengren, Anders H
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Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetesSolimena, Michele; Schulte, Anke M; Marselli, Lorella; Ehehalt, Florian; ... Marchetti, Piero

2017

Scientific Articles

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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cellOfori, Jones K.; Salunkhe, Vishal A.; Bagge, Annika; Vishnu, Neelanjan; ... Esguerra, Jonathan L. S.
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Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genesShcherbina, L.; Edlund, A.; Esguerra, J.L.S.; Abels, M.; ... Wierup, N.
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetesLy, Luong Dai; Xu, Shanhua; Choi, Seong-Kyung; Ha, Chae-Myeong; ... Park, Kyu-Sang
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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetesAxelsson, A. S.; Mahdi, T.; Nenonen, H. A.; Singh, T.; ... Rosengren, A. H.
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Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetesAxelsson, Annika S; Tubbs, Emily; Mecham, Brig; Chacko, Shaji; ... Rosengren, Anders H

2014

Scientific Articles

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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretionDayeh, Tasnim; Volkov, Petr; Salö, Sofia; Hall, Elin; ... Ling, Charlotte
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolismFadista, João; Vikman, Petter; Laakso, Emilia Ottosson; Mollet, Inês Guerra; ... Groop, Leif
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TCF7L2 is a master regulator of insulin production and processingZhou, Yuedan; Park, Soo-Young; Su, Jing; Bailey, Kathleen; ... Hansson, Ola

2012

Scientific Articles

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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic isletsMarchetti, P; Lupi, R; Bugliani, Marco; Kirkpatrick, Clare; ... Dotta, F
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A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human IsletsTaneera, Jalal; Lang, Stefan; Sharma, Amitabh; Fadista, Joao; ... Groop, Leif
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Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cellsEpstein, Sharon; Kirkpatrick, Clare; Castillon, Guillaume Alain; Muniz, Manuel; ... Riezman, Howard
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Defective Mitochondrial Function and Motility Due to Mitofusin 1 Overexpression in Insulin Secreting CellsPark, Kyu-Sang; Wiederkehr, Andreas; Wollheim, Claes;
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Human Krüppel-like factor 11 differentially regulates human insulin promoter activity in β-cells and non-β-cells via p300 and PDX1 through the regulatory sites A3 and CACCC boxPerakakis, Nikolaos; Danassi, Despoina; Alt, Marcus; Tsaroucha, Eleni; ... Päth, Günter
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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetesYang, Beatrice T; Dayeh, Tasnim A; Volkov, Petr A; Kirkpatrick, Clare; ... Ling, Charlotte
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Mitochondrial signals drive insulin secretion in the pancreatic β-cellWiederkehr, Andreas; Wollheim, Claes;
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Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stressSchvartz, Domitille; Coute, Yohann; Brunner, Yannick; Wollheim, Claes; Sanchez, Jean-Charles
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Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cellsAkhmedov, Dmitry; De Marchi, Umberto; Wollheim, Claes; Wiederkehr, Andreas;
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Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetesMahdi, Taman; Hänzelmann, Sonja; Salehi, Albert; Muhammed, Sarheed J; ... Rosengren, Anders H

2011

Scientific Articles

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Bone morphogenetic protein 3 controls insulin gene expression and is down-regulated in INS-1 cells inducibly expressing a hepatocyte nuclear factor 1A-maturity-onset diabetes of the young mutationBonner, Caroline; Farrelly, Angela M; Concannon, Caoimhín G; Dussmann, Heiko; ... Prehn, Jochen H M
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Hepatic nuclear factor 1alpha (HNF1alpha) dysfunction down-regulates X-box-binding protein 1 (XBP1) and sensitizes beta-cells to endoplasmic reticulum stressKirkpatrick, Clare; Wiederkehr, Andreas; Baquie, Mathurin; Akhmedov, Dmitry; ... Wollheim, Claes
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Imeglimin - A New Oral Anti-Diabetic that Targets the Three Key Defects of type 2 DiabetesFouqueray, Pascale; Leverve, Xavier; Fontaine, Eric; Baquie, Mathurin; ... Bozec, Sophie
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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic isletsYang, B T; Dayeh, T A; Kirkpatrick, Clare; Taneera, J; ... Ling, C
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Mitochondrial matrix calcium is an activating signal for hormone secretionWiederkehr, Andreas; Szanda, Gergo; Akhmedov, Dmitry; Mataki, Chikage; ... Wollheim, Claes
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Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cellsFeldmann, Nicole; del Rio, Rafael Martin; Gjinovci, Asllan; Tamarit-Rodriguez, Jorge; ... Wiederkehr, Andreas
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Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivoUhles, S; Wang, Haiyan; Bénardeau, A; Prummer, M; ... Sebokova, E

Thesis supervisions

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Mitochondrial signals and protein phosphorylation in nutrient-stimulated insulin secretionAkhmedov, Dmitry;

2010

Scientific Articles

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AMP-activated protein kinase mediates apoptosis in response to bioenergetic stress through activation of the pro-apoptotic Bcl-2 homology domain-3-only protein BMF.Kilbride, Seán M; Farrelly, Angela M; Bonner, Caroline; Ward, Manus W; ... Prehn, Jochen H M
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Early activation of the fatty acid metabolism pathway by chronic high glucose exposure in rat insulin secretory beta-cellsCoute, Yohann; Brunner, Yannick; Schvartz, Domitille; Hernandez, Celine; ... Sanchez, Jean-Charles
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Evidence against a direct role of klotho in insulin resistanceLorenzi, Olivier; Veyrat-Durebex, Christelle; Wollheim, Claes; Villemin, Pascal; ... Vischer, Ulrich Max
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Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidationWallin, Tina; Ma, Zuheng; Ogata, Hirotaka; Jørgensen, Ingrid Hals; ... Björklund, Anneli
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INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cellsBonner, Caroline; Bacon, Siobhán; Concannon, Caoimhín G; Rizvi, Syed R; ... Prehn, Jochen H M
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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cellsAkhmedov, Dmitry; Braun, Matthias; Mataki, Chikage; Park, Kyu-Sang; ... Wiederkehr, Andreas
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Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donorsKirkpatrick, Clare; Marchetti, Piero; Purrello, Francesco; Piro, Salvatore; ... Wollheim, Claes

Thesis supervisions

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Role of LRH-1/NR5A2 in islet physiology and pathophysiologyBaquie, Mathurin;
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