This guidance document describes the specific issues involved in dental multilayer ceramicsystems. The material interactions with regard to specific thermal and mechanical prop-erties are reviewed and the characteristics of dental tooth-shaped processing parameters(sintering, geometry, thickness ratio, etc.) are discussed. Several techniques for the mea-surement of bond quality and residual stresses are presented with a detailed discussion ofadvantages and disadvantages. In essence no single technique is able to describe adequatelythe all-ceramic interface. Invasive or semi-invasive methods have been shown to distort theinformation regarding the residual stress state while non-invasive methods are limited dueto resolution, field of focus or working depth. This guidance document has endeavored toprovide a scientific basis for future research aimed at characterizing the ceramic interfaceof dental restorations. Along with the methodological discussion it is seeking to provide anintroduction and guidance to relatively inexperienced researchers.