The Pauline neologism predestine was submitted, during the first three centuries of Christianity, the deepest semantic changes. This inquiry analyses a punctually transformation of this verb to substantivized concept accomplished by Origen, transformation burden of theological and ethical consequences. The Origenian Commentary on Pauline Epistle to the Romans is a most privileged observation place of this change, here called «normalization» or «ethicisation» of Paul's thought. After have clarified the key words involved, the Commentary on Romans is systematically analyzed (according to the Latin text, but also to the Greek fragments) following the normalization process of the subversive idea of the absolute sovereignty of God. This idea is here weakened in comparison to its Pauline matrix and paradoxically reconnected to a foreknowledge of God that (according to Origen) leaves intact the man's free will, Origenian pillar of conformation to God. The theoretical background of the Origen's operation is the polemic against the Marcionites and Gnostics who, according to Origen, would have perverted the genuine Pauline sense of action to predestine of God toward the humans people and the world.