Alkenyl copper reagents 26. Carbocupration of alkynes by reagents bearing a protected hydroxy or thiol function

Gardette, M.; Alexakis, Alexandre; Normant, Jean F.

doi:10.1016/S0040-4020(01)91428-0

Scientific article

English

Alkenyl copper reagents 26. Carbocupration of alkynes by reagents bearing a protected hydroxy or thiol function

ContributorsGardette, M.; Alexakis, Alexandre; Normant, Jean F.

Published inTetrahedron, vol. 41, no. 24, p. 5887-5899

Publication date1985

Abstract

Halohydrins, protected as ethers, acetals or chloro-magnesium alcoholates are sequentially transformed into the Li or Mg reagents and then into copper or cuprate derivatives. Addition to acetylene or propyne is discussed according to various parameters. The alkenyl copper or cuprate species, thus obtained, may react further with various electrophiles, leading to difunctionalized alkenes.

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Citation (ISO format)

GARDETTE, M., ALEXAKIS, Alexandre, NORMANT, Jean F. Alkenyl copper reagents 26. Carbocupration of alkynes by reagents bearing a protected hydroxy or thiol function. In: Tetrahedron, 1985, vol. 41, n° 24, p. 5887–5899. doi: 10.1016/S0040-4020(01)91428-0

Article (Published version)

Identifiers

PID : unige:8168
DOI : 10.1016/S0040-4020(01)91428-0

Journal ISSN0040-4020

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Alkenyl copper reagents 26. Carbocupration of alkynes by reagents bearing a protected hydroxy or thiol function

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