Chiral aminal templates 5. Preparation of chiral 3-carboxaldehydes-1,4-dihydropyridines

Gosmini, Romain; Mangeney, Pierre; Alexakis, Alexandre; Commerçon, M.; Normant, Jean F.

doi:10.1055/s-1991-20646

Scientific article

English

Chiral aminal templates 5. Preparation of chiral 3-carboxaldehydes-1,4-dihydropyridines

ContributorsGosmini, Romain; Mangeney, Pierre; Alexakis, Alexandre; Commerçon, M.; Normant, Jean F.

Published inSynlett, no. 2, p. 111-113

Publication date1991

Abstract

Organocopper reagents react with 1-acylpyridinium salts, bearing in the 3 position a chiral aminal [1-acyl-3-(trans-1,3-dimethyl-4, 5-diphenylimidazolidin-2-yl)pyridinium salts], to give after acidic hydrolysis chiral 4-substituted 1-acyl-1, 4-dihydropyridine-3-carboxaldehydes in high optical purity and in good chemical yield.

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Citation (ISO format)

GOSMINI, Romain et al. Chiral aminal templates 5. Preparation of chiral 3-carboxaldehydes-1,4-dihydropyridines. In: Synlett, 1991, n° 2, p. 111–113. doi: 10.1055/s-1991-20646

Article (Published version)

Identifiers

PID : unige:8158
DOI : 10.1055/s-1991-20646

Journal ISSN0936-5214

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Chiral aminal templates 5. Preparation of chiral 3-carboxaldehydes-1,4-dihydropyridines

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