Copper catalyzed tandem asymmetric conjugate addition cyclization reaction in presence of chiral phosphoramidite ligands

Li, Kangying; Alexakis, Alexandre

doi:10.1016/j.tetlet.2005.09.065

Scientific article

Letter

English

Copper catalyzed tandem asymmetric conjugate addition cyclization reaction in presence of chiral phosphoramidite ligands

ContributorsLi, Kangying; Alexakis, Alexandre

Published inTetrahedron letters, vol. 46, no. 46, p. 8019-8022

Publication date2005

Abstract

Copper-catalyzed intramolecular conjugate addition–cyclization in the presence of chiral phosphoramidite ligands was described. Cyclic products with multiple chiral centers were obtained with up to 93:7 diastereomeric ratio and 94% ee.

Keywords

Copper
Tandem
Conjugate addition
Cyclization
Chiral
Phosphoramidite ligands

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

LI, Kangying, ALEXAKIS, Alexandre. Copper catalyzed tandem asymmetric conjugate addition cyclization reaction in presence of chiral phosphoramidite ligands. In: Tetrahedron letters, 2005, vol. 46, n° 46, p. 8019–8022. doi: 10.1016/j.tetlet.2005.09.065

Article (Published version)

Identifiers

PID : unige:8122
DOI : 10.1016/j.tetlet.2005.09.065

Journal ISSN0040-4039

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Copper catalyzed tandem asymmetric conjugate addition cyclization reaction in presence of chiral phosphoramidite ligands

Copper-catalyzed intramolecular conjugate addition–cyclization in the presence of chiral phosphoramidite ligands was described. Cyclic products with multiple chiral centers were obtained with up to 93:7 diastereomeric ratio and 94% ee.

Technical informations