en
Scientific article
Letter
English

Copper catalyzed asymmetric conjugate addition-bromination of α, β unsaturated ketones : a highly effective one pot reaction for the synthesis of chiral α bromo β alkyl ketone

Published inTetrahedron letters, vol. 46, no. 35, p. 5823-5826
Publication date2005
Abstract

An efficient one-pot reaction for the synthesis of chiral a-bromo-ß-alkyl ketones was developed. The final products were obtained with excellent enantiomeric excess and good isolated yields. The synthetic potential was illustrated by the radical cyclization of the a-brominated ketone.

Keywords
  • Copper
  • Conjugate addition
  • Bromination
  • Chiral
  • One pot
Citation (ISO format)
LI, Kangying, ALEXAKIS, Alexandre. Copper catalyzed asymmetric conjugate addition-bromination of α, β unsaturated ketones : a highly effective one pot reaction for the synthesis of chiral α bromo β alkyl ketone. In: Tetrahedron letters, 2005, vol. 46, n° 35, p. 5823–5826. doi: 10.1016/j.tetlet.2005.06.144
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0040-4039
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Creation21.06.2010 14:16:32
First validation21.06.2010 14:16:32
Update time14.03.2023 15:48:12
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