Copper-catalysed asymmetric addition of diethylzinc to Boc-protected imines

Perron, Quentin; Alexakis, Alexandre

doi:10.1016/j.tetasy.2008.07.020

Scientific article

English

Copper-catalysed asymmetric addition of diethylzinc to Boc-protected imines

ContributorsPerron, Quentin; Alexakis, Alexandre

Published inTetrahedron: asymmetry, vol. 19, no. 15, p. 1871-1874

Publication date2008

Abstract

A new class of substrates has been tested in the addition of Et2Zn, catalyzed by copper and phosphoramidite, providing the expected a branched protected amine in quantitative conversion, good yield and excellent enantioselectivity up to 97%.

Affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

PERRON, Quentin, ALEXAKIS, Alexandre. Copper-catalysed asymmetric addition of diethylzinc to Boc-protected imines. In: Tetrahedron: asymmetry, 2008, vol. 19, n° 15, p. 1871–1874. doi: 10.1016/j.tetasy.2008.07.020

Article (Published version)

Identifiers

PID : unige:8118
DOI : 10.1016/j.tetasy.2008.07.020

ISSN of the journal0957-4166

500views

0downloads

Creation06/21/2010 2:16:31 PM

First validation06/21/2010 2:16:31 PM

Update time03/14/2023 3:48:11 PM

Status update03/14/2023 3:48:11 PM

Last indexation01/15/2024 8:27:39 PM

Archive ouverte UNIGE

Copper-catalysed asymmetric addition of diethylzinc to Boc-protected imines

A new class of substrates has been tested in the addition of Et2Zn, catalyzed by copper and phosphoramidite, providing the expected a branched protected amine in quantitative conversion, good yield and excellent enantioselectivity up to 97%.

Technical informations