Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

Perron, Quentin; Alexakis, Alexandre

doi:10.1016/j.tetasy.2007.10.018

Article scientifique

Anglais

Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

Contributeurs/tricesPerron, Quentin; Alexakis, Alexandre

Publié dansTetrahedron: asymmetry, vol. 18, no. 21, p. 2503-2506

Date de publication2007

Résumé

A new tertiary pseudo C2-symmetric diamine derived from (1S,2S)-(+)-pseudoephedrine was synthesized and tested in the enantioselective addition of methyllithium on different aromatic imines. A comparative study with a similar C2-symmetric ligand derived from the cyclohexane diamine showed better reactivity and enantioselectivity up to 91%.

Structure d'affiliation

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (format ISO)

PERRON, Quentin, ALEXAKIS, Alexandre. Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines. In: Tetrahedron: asymmetry, 2007, vol. 18, n° 21, p. 2503–2506. doi: 10.1016/j.tetasy.2007.10.018

Article (Published version)

Identifiants

PID : unige:8117
DOI : 10.1016/j.tetasy.2007.10.018

ISSN du journal0957-4166

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Création21.06.2010 14:16:31

Première validation21.06.2010 14:16:31

Heure de mise à jour14.03.2023 15:48:11

Changement de statut14.03.2023 15:48:11

Dernière indexation15.01.2024 20:27:38

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Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

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