Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

Perron, Quentin; Alexakis, Alexandre

doi:10.1016/j.tetasy.2007.10.018

Scientific article

English

Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

ContributorsPerron, Quentin; Alexakis, Alexandre

Published inTetrahedron: asymmetry, vol. 18, no. 21, p. 2503-2506

Publication date2007

Abstract

A new tertiary pseudo C2-symmetric diamine derived from (1S,2S)-(+)-pseudoephedrine was synthesized and tested in the enantioselective addition of methyllithium on different aromatic imines. A comparative study with a similar C2-symmetric ligand derived from the cyclohexane diamine showed better reactivity and enantioselectivity up to 91%.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

PERRON, Quentin, ALEXAKIS, Alexandre. Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines. In: Tetrahedron: asymmetry, 2007, vol. 18, n° 21, p. 2503–2506. doi: 10.1016/j.tetasy.2007.10.018

Article (Published version)

Identifiers

PID : unige:8117
DOI : 10.1016/j.tetasy.2007.10.018

Journal ISSN0957-4166

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Synthesis and application of a new pseudo C2-symmetric tertiary diamine for the enantioselective addition of MeLi to aromatic imines

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