Enantioselective ortho-lithiation of aminals of benzaldehyde chromiumtricarbonyl complex

Alexakis, Alexandre; Kanger, Tonis; Mangeney, Pierre; Rose-Munch, Françoise; Perrotey, Anne; Rose, Eric

doi:10.1016/0957-4166(94)00348-F

Scientific article

English

Enantioselective ortho-lithiation of aminals of benzaldehyde chromiumtricarbonyl complex

ContributorsAlexakis, Alexandre; Kanger, Tonis; Mangeney, Pierre; Rose-Munch, Françoise; Perrotey, Anne; Rose, Eric

Published inTetrahedron: asymmetry, vol. 6, no. 1, p. 47-50

Publication date1995

Abstract

The asymmetric ortho lithiation of aminals of benzaldehyde chromiumtricarbonyl complex is described. The best regioisomeric composition is attained with aminal 2d. Quenching with an electrophile and hydrolysis of the aminal back to the aldehyde afford a single enantiomer of the o-substituted benzaldehyde chromiumtricarbonyl complex.

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Citation (ISO format)

ALEXAKIS, Alexandre et al. Enantioselective ortho-lithiation of aminals of benzaldehyde chromiumtricarbonyl complex. In: Tetrahedron: asymmetry, 1995, vol. 6, n° 1, p. 47–50. doi: 10.1016/0957-4166(94)00348-F

Article (Published version)

Identifiers

PID : unige:8065
DOI : 10.1016/0957-4166(94)00348-F

Journal ISSN0957-4166

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Enantioselective ortho-lithiation of aminals of benzaldehyde chromiumtricarbonyl complex

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