Enantioselective addition of organolithium reagents on isoquinoline

Alexakis, Alexandre; Amiot, Franck

doi:10.1016/S0957-4166(02)00531-1

Scientific article

English

Enantioselective addition of organolithium reagents on isoquinoline

ContributorsAlexakis, Alexandre; Amiot, Franck

Published inTetrahedron: asymmetry, vol. 13, no. 19, p. 2117-2122

Publication date2002

Abstract

1-Methyl-1,2-dihydroisoquinoline and 1-butyl-1,2-dihydroisoquinoline were obtained by enantioselective addition of organolithium reagents on the isoquinoline. (-)-Sparteine was used as an external catalytic chiral ligand and an enantiomeric excess of 57% could be obtained.

Affiliation entities

Faculté des sciences / Section de chimie et biochimie / Département de chimie organique

Citation (ISO format)

ALEXAKIS, Alexandre, AMIOT, Franck. Enantioselective addition of organolithium reagents on isoquinoline. In: Tetrahedron: asymmetry, 2002, vol. 13, n° 19, p. 2117–2122. doi: 10.1016/S0957-4166(02)00531-1

Article (Published version)

Identifiers

PID : unige:8053
DOI : 10.1016/S0957-4166(02)00531-1

Journal ISSN0957-4166

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Creation06/21/2010 2:15:55 PM

First validation06/21/2010 2:15:55 PM

Update time03/14/2023 3:47:52 PM

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Enantioselective addition of organolithium reagents on isoquinoline

1-Methyl-1,2-dihydroisoquinoline and 1-butyl-1,2-dihydroisoquinoline were obtained by enantioselective addition of organolithium reagents on the isoquinoline. (-)-Sparteine was used as an external catalytic chiral ligand and an enantiomeric excess of 57% could be obtained.

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