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Scientific article
English

Asymmetric conjugate addition to alkylidene malonates

Published inTetrahedron: asymmetry, vol. 12, no. 8, p. 1151-1157
Publication date2001
Abstract

Dialkylzinc and trialkylaluminium reagents undergo conjugate addition to alkylidene malonates with 0.5% copper triflate as catalyst. The reaction could be made enantioselective by completing the reaction in the presence of 0.5–1.0 mol% of chiral phosphorus ligand. Enantiomeric excesses (e.e.s) of up to 73% could be attained with a ligand prepared from TADDOL and 2-naphthylcyclohexanol.

Citation (ISO format)
ALEXAKIS, Alexandre, BENHAIM, Cyril. Asymmetric conjugate addition to alkylidene malonates. In: Tetrahedron: asymmetry, 2001, vol. 12, n° 8, p. 1151–1157. doi: 10.1016/S0957-4166(01)00196-3
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ISSN of the journal0957-4166
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